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Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Autor: Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W., Hamrick, Jodie C., Daigle, Denis M., Cusick, Susan M., Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J., Pevear, Daniel C., Xerri, Luigi, Burns, Christopher J.

Publikováno v: Journal of Medicinal Chemistry; March 2020, Vol. 63 Issue: 6 p2789-2801, 13p

Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes

Autor: Trout, Robert E., Zulli, Allison, Mesaros, Eugen, Jackson, Randy W., Boyd, Steven, Liu, Bin, Hamrick, Jodie, Daigle, Denis, Chatwin, Cassandra L., John, Kaitlyn, McLaughlin, Lisa, Cusick, Susan M., Weiss, William J., Pulse, Mark E., Pevear, Daniel C., Moeck, Greg, Xerri, Luigi, Burns, Christopher J.

Publikováno v: Journal of Medicinal Chemistry; 20210101, Issue: Preprints

In Vitro Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program.

Autor: Karlowsky JA; IHMA, Schaumburg, Illinois, USA.; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada., Hackel MA; IHMA, Schaumburg, Illinois, USA., Wise MG; IHMA, Schaumburg, Illinois, USA., Six DA; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Uehara T; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Daigle DM; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Cusick SM; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Pevear DC; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Moeck G; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Sahm DF; IHMA, Schaumburg, Illinois, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Jan 24; Vol. 67 (1), pp. e0128122. Date of Electronic Publication: 2022 Dec 21.