Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.

Autor: Zhao Y; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A., Cushing PR; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A.; PRC, LakePharma, Worcester, MA, U.S.A., Smithson DC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, U.S.A.; DCS, Genentech, South San Francisco, CA, U.S.A., Pellegrini M; Department of Chemistry, Dartmouth College, Hanover, NH 03755, U.S.A., Pletnev AA; Department of Chemistry, Dartmouth College, Hanover, NH 03755, U.S.A., Al-Ayyoubi S; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A.; SAA, Navigant, New York City, NY, U.S.A., Grassetti AV; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A., Gerber SA; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A., Guy RK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, U.S.A.; RKG, School of Pharmacy, University of Kentucky, Lexington, KY, U.S.A., Madden DR; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U.S.A. drm0001@dartmouth.edu.

Publikováno v: Bioscience reports [Biosci Rep] 2018 Jul 06; Vol. 38 (4). Date of Electronic Publication: 2018 Jul 06 (Print Publication: 2018).

Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses.

Autor: Amacher JF; Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA., Cushing PR; Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA., Brooks L 3rd; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA., Boisguerin P; Institute of Medical Immunology, Charité, 10115 Berlin, Germany; Centre de Recherches de Biochimie Macromoleculaire, CRBM-CNRS, UMR-5237, UM1-UM2, University of Montpellier, Department of Molecular Biophysics and Therapeutics, 34293 Montpellier, France., Madden DR; Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA. Electronic address: drm0001@dartmouth.edu.

Publikováno v: Structure (London, England : 1993) [Structure] 2014 Jan 07; Vol. 22 (1), pp. 82-93. Date of Electronic Publication: 2013 Nov 07.

Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.

Autor: Kundu R; Department of Chemistry, Rice University, 6100 Main St., Houston, TX 77005, USA., Cushing PR, Popp BV, Zhao Y, Madden DR, Ball ZT

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2012 Jul 16; Vol. 51 (29), pp. 7217-20. Date of Electronic Publication: 2012 Jun 14.

Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor.

Autor: Amacher JF; Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755, USA., Cushing PR, Weiner JA, Madden DR

Publikováno v: Acta crystallographica. Section F, Structural biology and crystallization communications [Acta Crystallogr Sect F Struct Biol Cryst Commun] 2011 May 01; Vol. 67 (Pt 5), pp. 600-3. Date of Electronic Publication: 2011 Apr 28.

A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.

Autor: Cushing PR; Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755-3844, USA., Vouilleme L, Pellegrini M, Boisguerin P, Madden DR

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2010 Dec 17; Vol. 49 (51), pp. 9907-11.