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Akademický článek

6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.

Autor: Aspnes GE; Pfizer Medicine Design, Cambridge, MA 02139, United States., Bagley SW; Pfizer Medicine Design, Groton, CT 06340, United States., Coffey SB; Pfizer Medicine Design, Groton, CT 06340, United States., Conn EL; Pfizer Medicine Design, Groton, CT 06340, United States., Curto JM; Pfizer Medicine Design, Groton, CT 06340, United States., Edmonds DJ; Pfizer Medicine Design, Cambridge, MA 02139, United States., Genovino J; Pfizer Medicine Design, Groton, CT 06340, United States., Griffith DA; Pfizer Medicine Design, Cambridge, MA 02139, United States., Ingle G; Pfizer Medicine Design, Groton, CT 06340, United States., Jiao W; Pfizer Medicine Design, Groton, CT 06340, United States., Limberakis C; Pfizer Medicine Design, Groton, CT 06340, United States., Mathiowetz AM; Pfizer Medicine Design, Cambridge, MA 02139, United States., Piotrowski DW; Pfizer Medicine Design, Groton, CT 06340, United States. Electronic address: david.w.piotrowski@comcast.net., Rose CR; Pfizer Medicine Design, Groton, CT 06340, United States., Ruggeri RB; Pfizer Medicine Design, Cambridge, MA 02139, United States., Wei L; Pfizer Medicine Design, Groton, CT 06340, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Oct 01; Vol. 94, pp. 129454. Date of Electronic Publication: 2023 Aug 15.

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Akademický článek

Preparation of Azinones from (Cyclopropylmethoxy)azine Ethers.

Autor: Londregan AT; Development & Medical, Pfizer Worldwide Research, Cambridge, Massachusetts 02139, United States., Curto JM; Development & Medical, Pfizer Worldwide Research, Groton, Connecticut 06340, United States., Hastry E; Department of Chemistry, College of the Holy Cross, 1 College Street, Worcester, Massachusetts 01610, United States., Rose CR; Development & Medical, Pfizer Worldwide Research, Groton, Connecticut 06340, United States., Berritt S; Development & Medical, Pfizer Worldwide Research, Groton, Connecticut 06340, United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2023 May 05; Vol. 88 (9), pp. 5671-5675. Date of Electronic Publication: 2023 Apr 18.

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Akademický článek

A General Synthesis of Dihydronaphthyridinones with Aryl-Substituted Quaternary Benzylic Centers.

Autor: Murray JC; Pfizer Worldwide Research, Development & Medicine, Groton, Connecticut 06340, United States., Rose CR; Pfizer Worldwide Research, Development & Medicine, Groton, Connecticut 06340, United States., Curto JM; Pfizer Worldwide Research, Development & Medicine, Groton, Connecticut 06340, United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2023 Mar 03; Vol. 88 (5), pp. 3340-3345. Date of Electronic Publication: 2023 Feb 15.

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Akademický článek

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.

Autor: Griffith DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Edmonds DJ; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Fortin JP; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Kuzmiski JB; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Loria PM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Saxena AR; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Bagley SW; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Buckeridge C; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Curto JM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Derksen DR; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Dias JM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Griffor MC; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Han S; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Jackson VM; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Landis MS; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Lettiere D; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Limberakis C; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Liu Y; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Mathiowetz AM; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Patel JC; Sosei Heptares, Cambridge CB21 6DG, U.K., Piotrowski DW; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Price DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Ruggeri RB; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Tess DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jun 23; Vol. 65 (12), pp. 8208-8226. Date of Electronic Publication: 2022 Jun 01.

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Akademický článek

Palladium-Catalyzed Chemoselective Activation of sp ³ vs sp ² C-H Bonds: Oxidative Coupling To Form Quaternary Centers.

Autor: Hong G; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Key Laboratory for Advanced Materials, Institute of Fine Chemicals and School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China., Nahide PD; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Kumar Neelam U; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Amadeo P; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Vijeta A; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Curto JM; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Hendrick CE; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., VanGelder KF; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Kozlowski MC; Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Publikováno v: ACS catalysis [ACS Catal] 2019 Apr 05; Vol. 9 (4), pp. 3716-3724. Date of Electronic Publication: 2019 Mar 08.

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Akademický článek

Lewis Acid-Promoted Enantioselective Dearomative Spirocyclizations of Allenes.

Autor: Tcyrulnikov S; Department of Chemistry , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States., Curto JM; Department of Chemistry , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States., Gilmartin PH; Department of Chemistry , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States., Kozlowski MC; Department of Chemistry , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2018 Oct 05; Vol. 83 (19), pp. 12207-12212. Date of Electronic Publication: 2018 Sep 05.

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