Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer’s disease

Autor: Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Ariya Weiman Xiang, Myriam Bunting, Jason Shing-Cheong Kwan, Curtis Wai-Kin Wong, Leung-Wah Yick, Sookja Kim Chung, Karen Siu-Ling Lam, Ian E. Alexander, Aimin Xu, Koon-Ho Chan

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)

Abstract Adiponectin (APN) is an adipokine which predominantly expresses in adipocytes with neuroprotective and anti-inflammatory effects. We have recently indicated that circulatory trimeric APN can enter the brain by crossing the blood–brain barr

Externí odkaz: https://doaj.org/article/6eb49e54f24241c98ba0ec6dd4b65832

Benchmark Outcomes in Deceased Donor Kidney Transplantation: A Multicenter Analysis of 80 996 Transplants From 126 Centers

Autor: Gianluca Rompianesi, MD, PhD, FEBS, Roberto Montalti, MD, PhD, Georgios Vrakas, MD, PhD, Ali Zarrinpar, MD, PhD, Curtis Warren, MPH, CPH, Giuseppe Loiaco, MD, Fabiana Rubba, MD, PhD, Roberto I. Troisi, MD, PhD, FEBS

Publikováno v: Transplantation Direct, Vol 10, Iss 5, p e1618 (2024)

Background. We defined clinically relevant benchmark values in deceased donor kidney transplantation (KT), to assess the best achievable results in low-risk patient cohorts from experienced centers. Methods. We identified the “ideal” cases from t

Externí odkaz: https://doaj.org/article/504a4bcb32134d469801d99c062d0935

Epidemiology of Hepatic Steatosis at a Tertiary Care Center: An MRI-based Analysis

Autor: Fraum, TJ, Ludwig, DR, Kilian, S, Curtis, WA, Pilgram, TK, Sirlin, CB, Fowler, KJ

Publikováno v: Academic radiology, vol 25, iss 3
Fraum, TJ; Ludwig, DR; Kilian, S; Curtis, WA; Pilgram, TK; Sirlin, CB; et al.(2018). Epidemiology of Hepatic Steatosis at a Tertiary Care Center: An MRI-based Analysis. ACADEMIC RADIOLOGY, 25(3), 317-327. doi: 10.1016/j.acra.2017.10.002. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3jt035tv

RATIONALE AND OBJECTIVES:Little is known about the frequency and risk factors of hepatic steatosis in the tertiary care setting. Such knowledge is essential to clinicians making decisions about testing for this condition. Thus, our aim was to describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9346396189fd0d97fb29512969d113a5
https://escholarship.org/uc/item/3jt035tv

AcceSS and Equity in Transplantation (ASSET) New Zealand: Protocol for population-wide data linkage platform to investigate equity in access to kidney failure health services in New Zealand.

Autor: Rachel B Cutting, Angela C Webster, Nicholas B Cross, Heather Dunckley, Ben Beaglehole, Ian Dittmer, John Irvine, Curtis Walker, Merryn Jones, Melanie Wyld, Patrick J Kelly, Kate Wyburn, Nicole L De La Mata

Publikováno v: PLoS ONE, Vol 17, Iss 8, p e0273371 (2022)

BackgroundKidney transplantation is considered the ideal treatment for most people with kidney failure, conferring both survival and quality of life advantages, and is more cost effective than dialysis. Yet, current health systems may serve some peop

Externí odkaz: https://doaj.org/article/ac4d4316c83a446e8c799eff91b8be96

Tribute to Evan Weissman on behalf of the Syracuse-Onondaga Food Systems Alliance

Autor: Maura Ackerman, Mary Carney, Brandy Colebrook, Nel Gaudé, Elissa Johnson, LaToya Jones, David Knapp, Jessi Lyons, Peter Ricardo, Jonnell Robinson, Rachel Viens, Curtis Waterman

Publikováno v: Journal of Agriculture, Food Systems, and Community Development, Vol 10, Iss 4 (2021)

First paragraphs: Professor Evan Weissman was a driving force behind the formation of the Syracuse-Onondaga Food Systems Alliance (SOFSA)—a newly established food policy council based in the city to which he was so deeply com­mitted. Evan was a

Externí odkaz: https://doaj.org/article/9a64433e8d90487ea5b14b6fb1a13fe6