Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Curtis W. Conroy"'
Autor:
Curtis W. Conroy
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 13:465-472
Retinal drug concentrations were measured in treated and fellow eyes following topical administration of two potent and permeable carbonic anhydrase inhibitors, MK-927 and trifluoromethanesulfonamide (CF3SO2NH2) in the rabbit. Administration of 2 or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11344a4fa4bd1b4650f9127cea6fc7f9
https://doi.org/10.1089/jop.1997.13.465
https://doi.org/10.1089/jop.1997.13.465
Publikováno v:
Proteins: Structure, Function, and Genetics. 27:272-278
A study was undertaken to investigate whether diverse carbonic anhydrase (CA) isozymes (both native Zn as well as cobalt-substituted) are able to catalyze the hydrolysis of anions such as cyanide, cyanate, and thiocyanate. A controversy exists betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e4056b23cb2bf3f30a0a548c0e1dd23
https://doi.org/10.1002/(sici)1097-0134(199702)27:2<272::aid-prot12>3.0.co
https://doi.org/10.1002/(sici)1097-0134(199702)27:2<272::aid-prot12>3.0.co
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 13:23-30
Dorzolamide is a powerful inhibitor of carbonic anhydrase (CA) II that penetrates the sclera and cornea to reach the ciliary process and lowers formation of HCO3 and aqueous humor. The usual dose applied to the eye in treatment of glaucoma is 1 drop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea9317120403ab7782043d9ff748cbb
https://doi.org/10.1089/jop.1997.13.23
https://doi.org/10.1089/jop.1997.13.23
Publikováno v:
Bioorganic Chemistry. 24:262-272
The synthesis and inhibitory properties and stability of two nontoxic high-molecular-weight carbonic anhydrase inhibitors (F 3500 and POBUMS) are reported. F 3500 was prepared by the covalent linkage of aminobenzolamide, a potent carbonic anhydrase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::162e3672c9f85044d10bd7d73cf7f613
https://doi.org/10.1006/bioo.1996.0024
https://doi.org/10.1006/bioo.1996.0024
Autor:
Alden Mead, Curtis W. Conroy, Thomas H. Maren, Marvin L. Sears, H. Matsui, George C. Wynns, M Murakami
Publikováno v:
Experimental Eye Research. 62:409-418
Carbonic anhydrase inhibitors (CAIs) lower intraocular pressure by reducing aqueous flow. It has been thought that this pharmacologic reduction of aqueous flow is mediated by the ciliary epithelium, but it is not known whether this cellular action is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff65d9b30c3d32a9c3b9f7da1dc608e
https://doi.org/10.1006/exer.1996.0046
https://doi.org/10.1006/exer.1996.0046
Publikováno v:
European Journal of Medicinal Chemistry. 31:843-846
Summary 1,3,4-Thiadiazole-2,5-bissulfonamide was prepared from 2,5-dimercapto-1,3,4-thiadiazole, by a modification of the reported literature procedure, ie, via the sulfenamide. This compound is the lead molecule for designing important classes of ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe720b5490d5ed3a92274f773e3fbe5
https://doi.org/10.1016/s0223-5234(97)89847-9
https://doi.org/10.1016/s0223-5234(97)89847-9
Publikováno v:
Experimental Eye Research. 55:637-640
Carbonic anhydrase (CA) activity has been detected and quantified in the corneal epithelia of various mammalian species using a microchemical assay. The highest levels were found in the rabbit, followed by man, dog, sheep, and cat. Enzyme levels in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73955e0718981c2cdd48afe21a091d55
https://doi.org/10.1016/s0014-4835(05)80176-9
https://doi.org/10.1016/s0014-4835(05)80176-9
Autor:
Richard H. Buck, Curtis W. Conroy
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 8:233-240
The effects of cationic ammonium, phosphonium, and arsonium ion pairing salts as well as anionic organic and inorganic salts on the transcorneal permeability of ionized sulfonamide carbonic anhydrase inhibitors have been studied in the excised rabbit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775dbdf78048ca10e05af5d6df400a03
https://doi.org/10.1089/jop.1992.8.233
https://doi.org/10.1089/jop.1992.8.233
Publikováno v:
Experimental Eye Research. 50:27-36
A large number of sulfonamides have now been tested by the topical route for the lowering of intraocular pressure in the normal albino rabbit. Certain compounds with favorable balance between lipid and water solubility, and high activity against carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd78653f64828d93e5cd8cec54c217b
https://doi.org/10.1016/0014-4835(90)90007-h
https://doi.org/10.1016/0014-4835(90)90007-h
Autor:
Thomas H. Maren, Curtis W. Conroy
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 15(2)
The accession to cornea, aqueous humor and ultimately ciliary process was studied for a series of 6 sulfonamides which differed in their free acid lipophilicities. The drugs were applied as 5 mM solutions at pH 5 in unionized form or in chiefly ioniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7e7461765e4ae9edf90d32e038ce1e
https://pubmed.ncbi.nlm.nih.gov/10229495
https://pubmed.ncbi.nlm.nih.gov/10229495