Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Curtis S Younkin"'
Autor:
Olivia J Conway, Minerva M Carrasquillo, Xue Wang, Jenny M Bredenberg, Joseph S Reddy, Samantha L Strickland, Curtis S Younkin, Jeremy D Burgess, Mariet Allen, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Alexandra I Soto, Ronald L Walton, Bradley F Boeve, Ronald C Petersen, John A Lucas, Tanis J Ferman, William P Cheshire, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, Nilüfer Ertekin-Taner
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background Rare coding variants ABI3_rs616338-T and PLCG2_rs72824905-G were identified as risk or protective factors, respectively, for Alzheimer’s disease (AD). Methods We tested the association of these variants with five neurodegenerati
Externí odkaz:
https://doaj.org/article/26aae77c26cb4a6c9e381ff00070adea
Autor:
Minerva M. Carrasquillo, Vivekananda Sarangi, Steven G. Younkin, Todd E. Golde, Joseph S. Reddy, Cyril Pottier, Yingxue Ren, Jason P. Sinnwell, Yan W. Asmann, Owen A. Ross, Xue Wang, Mariet Allen, Curtis S. Younkin, Joanna M. Biernacka, Gregory D. Jenkins, Rosa Rademakers, Nilufer Taner, Brandon J. Coombes, George M. Eisenberg
By analyzing whole-exome data from the Alzheimer’s disease sequencing project (ADSP), we identify a set of 4 genes that show highly significant association with Alzheimer’s disease (AD). These genes were identified within a human TREM2 co-express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7999507c2d66d225996add1dfac2a452
https://doi.org/10.1101/2020.11.13.381640
https://doi.org/10.1101/2020.11.13.381640
Autor:
Krishna R Kalari, David eRossell, Brian M Necela, Yan W Asmann, Asha eNair, Saurabh eBaheti, Jennifer M Kachergus, Curtis S Younkin, Tiffany R Baker, Jennifer M Carr, Xiaojia eTang, Michael eWalsh, High Seng eChai, Zhifu eSun, Steven N Hart, Alexey A Leontovich, Asif eHossain, Jean-Pierre eKocher, Edith A Perez, David N Reisman, Alan P Fields, E. Aubrey eThompson
Publikováno v:
Frontiers in Oncology, Vol 2 (2012)
KRAS mutations are highly prevalent in non-small cell lung cancer (NSCLC), and tumors harboring these mutations tend to be aggressive and resistant to chemotherapy. We used next-generation sequencing technology to identify pathways that are specifica
Externí odkaz:
https://doaj.org/article/131a3715ba6d4f08a6790b57ec719bed
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.
Autor:
Fanggeng Zou, High Seng Chai, Curtis S Younkin, Mariet Allen, Julia Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Asha A Nair, Sumit Middha, Sooraj Maharjan, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Ryan Palusak, Sarah Lincoln, Gina Bisceglio, Constantin Georgescu, Naomi Kouri, Christopher P Kolbert, Jin Jen, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Alzheimer's Disease Genetics Consortium, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002707 (2012)
Genetic variants that modify brain gene expression may also influence risk for human diseases. We measured expression levels of 24,526 transcripts in brain samples from the cerebellum and temporal cortex of autopsied subjects with Alzheimer's disease
Externí odkaz:
https://doaj.org/article/a148bd6289944186a3a7dd01c3a33cac
Autor:
Ronald C. Petersen, Ronald L. Walton, Jeremy D. Burgess, Alexandra I. Soto, Minerva M. Carrasquillo, Nilufer Ertekin-Taner, Sarah Lincoln, Dennis W. Dickson, Joseph S. Reddy, Kimberly G. Malphrus, Ryan J. Uitti, John A. Lucas, Owen A. Ross, Curtis S. Younkin, Zbigniew K. Wszolek, Thuy Nguyen, Samantha L. Strickland, Tanis J. Ferman, Bradley F. Boeve, Jay A. van Gerpen, Jenny M. Bredenberg, Neill R. Graff-Radford, Xue Wang, William P. Cheshire, Olivia J. Conway, Mariet Allen
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Rare coding variants ABI3_rs616338-T and PLCG2_rs72824905-G were identified as risk or protective factors, respectively, for Alzheimer’s disease (AD). Methods We tested the association of these variants with five neurodegenerative diseas
Autor:
Rui Chang, Samantha L. Strickland, Naomi Kouri, Joseph S. Reddy, Kuixi Zhu, Cory C. Funk, Jeremy D. Burgess, Nilufer Ertekin-Taner, Nathan D. Price, Shunsuke Koga, Daniel J. Serie, Curtis S. Younkin, Melissa E. Murray, Julia E. Crook, Thuy T. Nguyen, Minerva M. Carrasquillo, Kimberly G. Malphrus, Steven G. Younkin, Todd E. Golde, Xue Wang, Yan W. Asmann, Sarah Lincoln, Mariet Allen, Melissa Alamprese, Dennis W. Dickson
Publikováno v:
Acta Neuropathologica
Progressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder characterized by tau pathology in neurons and glial cells. Transcriptional regulation has been implicated as a potential mechanism in conferring disease risk and neurop
Autor:
Minerva M Carrasquillo, Olivia Belbin, Fanggeng Zou, Mariet Allen, Nilufer Ertekin-Taner, Morad Ansari, Samantha L Wilcox, Mariah R Kashino, Li Ma, Linda H Younkin, Samuel G Younkin, Curtis S Younkin, Toros A Dincman, Melissa E Howard, Chanley C Howell, Chloe M Stanton, Christopher M Watson, Michael Crump, Veronique Vitart, Caroline Hayward, Nicholas D Hastie, Igor Rudan, Harry Campbell, Ozren Polasek, Kristelle Brown, Peter Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Patrick G Kehoe, David M Mann, A David Smith, Helen Beaumont, Donald Warden, Clive Holmes, Reinhard Heun, Heike Kölsch, Noor Kalsheker, V Shane Pankratz, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Alan F Wright, Steven G Younkin, Kevin Morgan
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8764 (2010)
BACKGROUND:The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD). METHODOLOGY/PRINCIPAL FINDINGS:We examined conserved regions of IDE and its 10 kb flanks in 269 AD cases and
Externí odkaz:
https://doaj.org/article/30705a34921a465983afe4754bf3908f
Autor:
Jeremy D. Burgess, Christopher Medway, Chen Wang, Daniel J. Serie, Yan W. Asmann, Thuy Nguyen, Mariet Allen, Samantha L. Strickland, Joanna Siuda, Michaela Kachadoorian, Kevin Morgan, Kimberly G. Malphrus, David A. Bennett, Curtis S. Younkin, Xue Wang, Sarah Lincoln, Philip L. De Jager, Neill R. Graff-Radford, Dennis W. Dickson, Julia E. Crook, Pritha Chanana, Ronald C. Petersen, Nilufer Ertekin-Taner, Shivani Aryal, Steven G. Younkin, Todd E. Golde, Nathan D. Price, Asha Nair, Charles C. White, Minerva M. Carrasquillo
Publikováno v:
Alzheimer's & Dementia. 13:663-673
Introduction We hypothesized that common Alzheimer's disease (AD)-associated variants within the triggering receptor expressed on myeloid ( TREM ) gene cluster influence disease through gene expression. Methods Expression microarrays on temporal cort
Autor:
Daniel J. Serie, Zhifu Sun, Nathan D. Price, Tamas Ordog, Sarah Lincoln, Gerard D. Schellenberg, Dennis W. Dickson, Jeremy D. Burgess, Steven G. Younkin, Chen Wang, Todd E. Golde, Saurabh Baheti, Travis Ballard, Xue Wang, Thuy Nguyen, Julia E. Crook, Curtis S. Younkin, Kimberly G. Malphrus, Melissa E. Murray, Naomi Kouri, Nilufer Ertekin-Taner, Yan W. Asmann, Mariet Allen, Minerva M. Carrasquillo
Publikováno v:
Acta Neuropathologica. 132:197-211
To determine the effects of single nucleotide polymorphisms (SNPs) identified in a genome-wide association study of progressive supranuclear palsy (PSP), we tested their association with brain gene expression, CpG methylation and neuropathology. In 1
Autor:
Joseph S. Reddy, Maria T. Greig Custo, Sarah Lincoln, Ronald C. Petersen, Minerva M. Carrasquillo, Kimberly G. Malphrus, Curtis S. Younkin, Neill R. Graff-Radford, Thuy Nguyen, Jenny M. Bredenberg, Dennis W. Dickson, Nilufer Ertekin-Taner, Olivia J. Conway, Mariet Allen, Ranjan Duara
Publikováno v:
Alzheimer's & Dementia. 14