Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Curtis Ray Lacy"'
Autor:
Naotake Funamizu, Curtis Ray Lacy, Kaori Fujita, Kenei Furukawa, Takeyuki Misawa, Katsuhiko Yanaga, Yoshinobu Manome
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37424 (2012)
Tetrahydrouridine (THU) is a well characterized and potent inhibitor of cytidine deaminase (CDA). Highly expressed CDA catalyzes and inactivates cytidine analogues, ultimately contributing to increased gemcitabine resistance. Therefore, a combination
Externí odkaz:
https://doaj.org/article/142cd828635e4bce95a26d2e754c701a
Publikováno v:
International Journal of Oncology.
Chemotherapy resistance (congenital or acquired) is one of the principal challenges for the treatment of pancreatic carcinoma. Recent evidence has demonstrated that epithelial to mesenchymal transition (EMT) is associated with chemoresistance in panc
Publikováno v:
International Journal of Oncology. 47:1981-1988
The present study investigated the relationship between microRNA-203 (miR-203) and the p53 upregulated modulator of apoptosis (Puma) in colon (HCT116) and lung cancer (A549) cells. Colon and lung cancer cell lines were selected for this study since a
Autor:
Naotake Funamizu, Katsuhiko Yanaga, Yukiharu Hiyoshi, Curtis Ray Lacy, Atsushi Takai, Sonya Parpart
Publikováno v:
International Journal of Oncology. 44:725-734
Recent studies have demonstrated that deregulated microRNA (miR) expression is implicated in the development of human cancers. In the aberrant miR expression, miR-301 is upregulated in cancers, such as pancreatic, colorectal and oral carcinoma. Based
Autor:
H. Richard Alexander, Geng Zhang, Timothy C. Back, Harris G. Yfantis, S. Perwez Hussain, Aaron J. Schetter, Anirban Maitra, Curtis Ray Lacy, Dong H. Lee, Peijun He, Naotake Funamizu, Timothy A. Chan, Jeffrey Subleski, Michael Ghadimi, Thomas Ried, Chaoxin Hu, Nader Hanna, Jonathan M. Weiss, Katsuhiko Yanaga, Jochen Gaedcke
Publikováno v:
International Journal of Cancer. 132:785-794
MIF is a proinflammatory cytokine and is implicated in cancer. A higher MIF level is found in many human cancer and cancer-prone inflammatory diseases, including chronic pancreatitis and pancreatic cancer. We tested the hypothesis that MIF contribute
Autor:
Dong H. Lee, Geng Zhang, Curtis Ray Lacy, Thomas Ried, Harris G. Yfantis, Aaron J. Schetter, Peijun He, Raffit Hassan, H. Richard Alexander, B. Michael Ghadimi, Naotake Funamizu, S. Perwez Hussain, Jochen Gaedcke, Nader Hanna, Anirban Maitra
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e31507 (2012)
PLoS ONE, Vol 7, Iss 2, p e31507 (2012)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. To identify biologically relevant genes with prognostic and therapeutic significance in PDAC, we first performed the microarray gene-expression profiling in 45 match
Autor:
Tadashi Uwagawa, Yuko Kamata, Yoshinobu Manome, Naotake Funamizu, Takeyuki Misawa, Katsuhiko Yanaga, Curtis Ray Lacy
Publikováno v:
Pancreas. 41(1)
This study aimed to determine whether the treatment of pancreatic carcinoma can be defined on the basis of the expression of genes involved in gemcitabine metabolism and whether combination treatment is more effective than conventional treatment.Four
Autor:
Curtis Ray Lacy, Kaori Fujita, Takeyuki Misawa, Kenei Furukawa, Katsuhiko Yanaga, Yoshinobu Manome, Naotake Funamizu
Publikováno v:
Funamizu, Naotake; Lacy, Curtis Ray; Fujita, Kaori; Furukawa, Kenei; Misawa, Takeyuki; Yanaga, Katsuhiko; et al.(2012). Tetrahydrouridine Inhibits Cell Proliferation through Cell Cycle Regulation Regardless of Cytidine Deaminase Expression Levels. PLoS ONE, 7(5), e37424. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/42g837h4
PLoS ONE, Vol 7, Iss 5, p e37424 (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 5, p e37424 (2012)
PLoS ONE
Tetrahydrouridine (THU) is a well characterized and potent inhibitor of cytidine deaminase (CDA). Highly expressed CDA catalyzes and inactivates cytidine analogues, ultimately contributing to increased gemcitabine resistance. Therefore, a combination