Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Curtis R. Kelly"'
Autor:
Jill Sturdivant, Stuart S. Williams, Maria Ina, Meredith Weksler, Alan McDougal, Daphne Clancy, Mitchell A. deLong, Natalie Girouard, Maria Zaretskaia, Karen Brennan, Angela Glendenning, Briana Foley, Cheng-Wen Lin, Jeffrey C. White, Casey Kopczynski, Curtis R. Kelly
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 39:117-127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1bb6c5599d48ae8e925a8fa5ae77c4
https://doi.org/10.1089/jop.2022.0129
https://doi.org/10.1089/jop.2022.0129
Autor:
Abdelmoula Namil, Mark R. Hellberg, Andrew Rusinko, Bryon S. Severns, Jennifer Ward, Colene Drace, Iok-Hou Pang, Shenouda Yacoub, Keith D. Combrink, Curtis R. Kelly, Byron Li, Marsha A. McLaughlin, Raj Patil, N.A. Sharif, Hwang Hsing Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1875-1879
A series of 2,3,6-pyrazine Rho Kinase inhibitors were optimized for in vivo activity for topical ocular dosing. Modifications of the 2-(piperazin-1-yl)pyrazine derivatives produced compounds with improved solubility and physicochemical properties. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d182bc1267668fdba6283e228caac75f
https://doi.org/10.1016/j.bmcl.2014.03.017
https://doi.org/10.1016/j.bmcl.2014.03.017
Autor:
Curtis R. Kelly, Craig E. Crosson, Carl B. Camras, Shahid Husain, Colene D. Drace, Parvaneh Katoli, Marsha A. McLaughlin, Najam A. Sharif, Gui Lin Zhan, Carol B. Toris
Publikováno v:
Experimental Eye Research. 88:386-397
The aims of the current studies were to determine the in vitro and in vivo ocular and non-ocular pharmacological properties of cabergoline using well documented receptor binding, cell-based functional assays, and in vivo models. Cabergoline bound to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6ccd5baa59c9c2f4d65806dc88b6b5
https://doi.org/10.1016/j.exer.2008.10.003
https://doi.org/10.1016/j.exer.2008.10.003
Autor:
Jesse A. May, Najam A. Sharif, Hwang-Hsing Chen, John C. Liao, Curtis R. Kelly, Richard A. Glennon, Richard Young, Jun-Xu Li, Kenner C. Rice, Charles P. France
Publikováno v:
Pharmacology Biochemistry and Behavior. 91:307-314
AL-38022A is a novel synthetic serotonergic (5-HT) ligand that exhibited high affinity for each of the 5-HT2 receptor subtypes (Ki ≤ 2.2 nM), but a significantly lower (>100-fold less) affinity for other 5-HT receptors. In addition, AL-38022A displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6141a94380080c4f073dc5f24b951f7
https://doi.org/10.1016/j.pbb.2008.07.015
https://doi.org/10.1016/j.pbb.2008.07.015
Autor:
Mark R. Hellberg, Bryon S. Severns, William F. Holt, Richard Young, Richard A. Glennon, Thomas R. Dean, Najam A. Sharif, Hwang-Hsing Chen, Curtis R. Kelly, Marsha A. McLaughlin, Jesse A. May
Publikováno v:
Journal of medicinal chemistry. 58(22)
Recently, it has been reported that 5-HT2 receptor agonists effectively reduce intraocular pressure (IOP) in a nonhuman primate model of glaucoma. Although 1-[(2S)-2-aminopropyl]indazol-6-ol (AL-34662) was shown to have good efficacy in this nonhuman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efded27acf90f8c38ea878165340de3
https://pubmed.ncbi.nlm.nih.gov/26551970
https://pubmed.ncbi.nlm.nih.gov/26551970
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 22:389-401
The aim of this study was to characterize the serotonin (5-hydroxytryptamine; 5-HT) receptors that mediate phosphoinositide (PI) hydrolysis and intracellular Ca2+ ([Ca2+]i) mobilization in isolated cells of human ciliary muscle (h-CM) from multiple d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce983cdc657bb0e543c8293bc1c9b7
https://doi.org/10.1089/jop.2006.22.389
https://doi.org/10.1089/jop.2006.22.389
Autor:
Curtis R. Kelly, Najam A. Sharif
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 317:1254-1261
The present study investigated the serotonin-induced increase in phosphoinositide hydrolysis and mobilization of intracellular Ca2+ ([Ca2+]i) in human uterine smooth muscle cells (HUSMCs) to identify the serotonergic receptor positively coupled to ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba9d34501b78019e18fd9ac8d50813f
https://doi.org/10.1124/jpet.105.100172
https://doi.org/10.1124/jpet.105.100172
Publikováno v:
Biochemistry. 39:11467-11476
Tissue factor (TF) is a transmembrane receptor that initiates the thrombogenic cascade by assembly with the serine protease factor VII or VIIa (VII/VIIa) resulting in formation of the bimolecular active complex TF.VIIa. Chemical cross-linking studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32673e484d4b5de8750286d1ffb0d1bf
https://doi.org/10.1021/bi000986p
https://doi.org/10.1021/bi000986p
Autor:
Curtis R. Kelly, Yu Wang, Laura Klekar, Parvaneh Katoli, Dorette Z. Ellis, Shenouda Yacoub, Linya Li, Allan R. Shepard, Shouxi Xu, Gwenette Hamilton, Najam A. Sharif, Nasreen Jacobson, David Earnest
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 30(1)
To localize mRNA and protein of bradykinin (BK) receptors, BK precursor polypeptide (kininogen) mRNA, and to study functional biochemical pharmacology of the signal transduction processes mediated by B2-receptors in isolated human trabecular meshwork
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb73714d0d5e1219b7878ae83bf5dfec
https://pubmed.ncbi.nlm.nih.gov/24236827
https://pubmed.ncbi.nlm.nih.gov/24236827
Autor:
Edward G. D. Tuddenham, Curtis R. Kelly, J. R. Schullek, Thomas S. Edgington, Igor Polikarpov, Wolfram Ruf, David M. A. Martin, C.W.G. Boys
Publikováno v:
Biochemistry. 34:6310-6315
Tissue factor is the cellular receptor and macromolecular enzymatic cofactor for the serine protease coagulation factor VIIa. The ligand binding extracellular domain of tissue factor consists of two structural modules which fold similar to fibronecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13ad08c378a8d7bc1cf906b4f4937f1
https://doi.org/10.1021/bi00019a008
https://doi.org/10.1021/bi00019a008