Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Curtis R Pickering"'
Autor:
Eric T Clambey, Jacob Gadwa, Thomas E Bickett, Laurel B Darragh, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Sana D Karam, Michael W Knitz, Ayman J Oweida, Adam C Mueller, Douglas G Osborne, Xiyuan Bai, Sarah E Ferrara, Mary-Keara Boss, Andrew Goodspeed, Matthew A Burchill, Beth A Jirón Tamburini, Edward D Chan, Curtis R Pickering
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate the
Externí odkaz:
https://doaj.org/article/cbf79a9cbfcd4744b19d4b8a1b088264
Autor:
Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Qi Wang, Ximing Tang, Sen Pathak, Maria Gabriela Raso, Jared K. Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promotes tumor development and progression. The GOF activities of TP53 mutati
Externí odkaz:
https://doaj.org/article/439599fe4b0841cea0b2d92022192f6d
Deep learning of cell spatial organizations identifies clinically relevant insights in tissue images
Autor:
Shidan Wang, Ruichen Rong, Qin Zhou, Donghan M. Yang, Xinyi Zhang, Xiaowei Zhan, Justin Bishop, Zhikai Chi, Clare J. Wilhelm, Siyuan Zhang, Curtis R. Pickering, Mark G. Kris, John Minna, Yang Xie, Guanghua Xiao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Recent advancements in tissue imaging techniques have facilitated the visualization and identification of various cell types within physiological and pathological contexts. Despite the emergence of cell-cell interaction studies, there is a l
Externí odkaz:
https://doaj.org/article/961e40ca5e004fd7933cd040aeea0ee3
Autor:
Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product. Here the authors describe a gain of function of several CREBBP mutations leading to baseline hyper-acet
Externí odkaz:
https://doaj.org/article/9e9b057abf944363949c648ff88a38f3
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1)
Autor:
Chieko Michikawa, Vancheswaran Gopalakrishnan, Amani M. Harrandah, Tatiana V Karpinets, Rekha Rani Garg, Randy A. Chu, Yuk Pheel Park, Sasanka S. Chukkapallia, Nikhita Yadlapalli, Kelly C. Erikson-Carter, Frederico Omar Gleber-Netto, Elias Sayour, Ann Progulske-Fox, Edward K.L. Chan, Xiaogang Wu, Jianhua Zhang, Christian Jobin, Jennifer A. Wargo, Curtis R. Pickering, Jeffrey N. Myers, Natalie Silver
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 31, Iss , Pp 100813- (2022)
Recently, increased number of studies have demonstrated a relationship between the oral microbiome and development of head and neck cancer, however, there are few studies to investigate the role of oral bacteria in the context of the tumor microenvir
Externí odkaz:
https://doaj.org/article/974eabb64e8544b885cd3daac2802a36
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Oral premalignant lesions (OPLs) are the precursors to oral cavity cancers, and have variable rates of progression to invasive disease. As an intermediate state, OPLs have acquired a subset of the genomic alterations while arising in an oral inflamma
Externí odkaz:
https://doaj.org/article/4c8eb37d4bd44b0aaa250cdac0db8217
Autor:
Jie Ma, Yong Fu, Yao-yao Tu, Ying Liu, Yi-ran Tan, Wu-tong Ju, Curtis R. Pickering, Jeffrey N. Myers, Zhi-yuan Zhang, Lai-ping Zhong
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background With the development of sequencing technologies, there may be some disputes on sequencing analysis. The aim of this study was to investigate different allele frequency thresholds of mutations in targeted genes on prognostic analys
Externí odkaz:
https://doaj.org/article/d3c508d0988b40168b1e71bce6babb1f
Autor:
Timothy J. Abram, Curtis R. Pickering, Alexander K. Lang, Nancy E. Bass, Rameez Raja, Cynthia Meena, Amin M. Alousi, Jeffrey N. Myers, John T. McDevitt, Ann M. Gillenwater, Nadarajah Vigneswaran
Publikováno v:
Translational Oncology, Vol 11, Iss 2, Pp 477-486 (2018)
Fanconi anemia (FA) is a hereditary genomic instability disorder with a predisposition to leukemia and oral squamous cell carcinomas (OSCCs). Hematopoietic stem cell transplantation (HSCT) facilitates cure of bone marrow failure and leukemia and thus
Externí odkaz:
https://doaj.org/article/b534fdfe555548f78579fe57c6f0ebe8
Autor:
Cristina P Rodriguez, Hyunseok Kang, Jessica L Geiger, Barbara Burtness, Christine H Chung, Curtis R Pickering, Carole Fakhry, Quynh Thu Le, Sue S Yom, Thomas J Galloway, Erica Golemis, Alice Li, Jeffrey Shoop, Stuart Wong, Ranee Mehra, Heath Skinner, Nabil F Saba, Elsa R Flores, Jeffrey N Myers, James M Ford, Rachel Karchin, Robert L Ferris, Charles Kunos, Jean M Lynn, Shakun Malik
Publikováno v:
JNCI: Journal of the National Cancer Institute. 114:1619-1627
TP53 mutation is the most frequent genetic event in head and neck squamous cell carcinoma (HNSCC), found in more than 80% of patients with human papillomavirus–negative disease. As mutations in the TP53 gene are associated with worse outcomes in HN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac60138b8df09dbba2ae3932d5b6953
https://doi.org/10.1093/jnci/djac163
https://doi.org/10.1093/jnci/djac163
Autor:
Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang, Yu-Sun Chang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Oral squamous cell carcinoma is a prevalent malignancy in Taiwan. Here, the authors show that OSCC in Taiwanese show a frequent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased expression of A3A, which is s
Externí odkaz:
https://doaj.org/article/3b8f11eb8dfc4c03be267e249342f6d9