Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Curtis Maier"'
Autor:
Susan B Laffan, Andrew S Thomson, Shing Mai, Cindy Fishman, Takahito Kambara, Kiran Nistala, James T Raymond, Shugui Chen, Thulasi Ramani, Laura Pageon, Rodd Polsky, Mark Watkins, Gemma Ottolangui, John R White, Curtis Maier, Michael Herdman, Gerben Bouma
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231655 (2020)
Despite the potential for the chemokine class as therapeutic targets in immune mediated disease, success has been limited. Many chemokines can bind to multiple receptors and many receptors have multiple ligands, with few exceptions. One of those exce
Externí odkaz:
https://doaj.org/article/ee33790a5c0946eb8e5ea303f460bcc0
Autor:
Andrea Kiessling, Frederic Brouta, Wendy J. Freebern, Marlowe J. Schneidkraut, Timothy K. MacLachlan, Birgit Fogal, Shawn Jay Berens, Sven Kronenberg, Curtis Maier, Laura Andrews, Cris Kamperschroer, Danuta J. Herzyk, Nikki Marshall
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 119
With the growth of monoclonal antibodies and other proteins as major modalities in the pharmaceutical industry, there has been an increase in pharmacology and toxicity testing of biotherapeutics in animals. Animals frequently mount an immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8126077e8f54fc5cf1ff6cfd870332
https://pubmed.ncbi.nlm.nih.gov/33220389
https://pubmed.ncbi.nlm.nih.gov/33220389
Autor:
Gemma Ottolangui, Curtis Maier, Shugui Chen, James T. Raymond, Rodd Polsky, Cindy E. Fishman, Michael Herdman, Takahito Kambara, John R. White, Thulasi Ramani, Laura Pageon, Susan B. Laffan, Shing Mai, Kiran Nistala, Andrew S. Thomson, Gerben Bouma, Mark S Watkins
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231655 (2020)
PLoS ONE, Vol 15, Iss 4, p e0231655 (2020)
Despite the potential for the chemokine class as therapeutic targets in immune mediated disease, success has been limited. Many chemokines can bind to multiple receptors and many receptors have multiple ligands, with few exceptions. One of those exce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d6ffd7d2872d680d4c786594a745e5
http://europepmc.org/articles/PMC7180069
http://europepmc.org/articles/PMC7180069
Autor:
Steve Enoch, Kohji Aoyama, Janine Ezendam, Colin M. North, Antti Karjalainen, Susan M. Tarlo, Cynthia Graham, Connie L. Chen, Juergen Pauluhn, Erwin Ludo Roggen, Amber K. Goetz, Curtis Maier, MaryJane K. Selgrade, Jon A. Hotchkiss, Ian Kimber
Publikováno v:
Regulatory Toxicology and Pharmacology. 80:295-309
Respiratory tract sensitization can have significant acute and chronic health implications. While induction of respiratory sensitization is widely recognized for some chemicals, validated standard methods or frameworks for identifying and characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b74506df51b7f64f48fe3f42b05d9d
https://doi.org/10.1016/j.yrtph.2016.06.006
https://doi.org/10.1016/j.yrtph.2016.06.006
Autor:
Helen G. Haggerty, Danuta J. Herzyk, Rafael Ponce, B.D. Preston, Curtis Maier, R.D. Mellon, Frank R. Brennan, Herve Lebrec, Cris Kamperschroer, D. Weinstock
Publikováno v:
Regulatory Toxicology and Pharmacology. 75:72-80
Profound immunosuppression (e.g., AIDS, transplant therapy) is epidemiologically associated with an increased cancer risk, and often with oncogenic viruses. It is currently unclear how broadly this association translates to therapeutics that modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4513b23e60dffc79c3b277fd6137fbd0
Autor:
J. Larkin, Jean Shearin, P.B. Tran, F. Liu, Louis Elefante, Thomas Lohr, Yu Xue, Rachel E. Miller, Caroline Genell, Curtis Maier, Jui-Lan Su, Rosalie Matico, Anne-Marie Malfait, Christopher Matheny
Publikováno v:
Osteoarthritis and Cartilage. 23(8):1254-1266
Summary Objective/Method Aggrecanase activity, most notably ADAMTS-5, is implicated in pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS-5 and ADAMTS-4 were generated and in vitro , ex vivo and in vivo systems we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cc7998a1296817849a88f3d90f6e88
Autor:
Maggie Dempster, Marque Todd, Curtis Maier, Jessica Couch, Lise I. Loberg, Timothy K. MacLachlan, Jan Willem van der Laan, Shawn Heidel, Kathryn Chapman, Fiona Sewell
Publikováno v:
mAbs
The market for biotherapeutic monoclonal antibodies (mAbs) is large and is growing rapidly. However, attrition poses a significant challenge for the development of mAbs, and for biopharmaceuticals in general, with large associated costs in resource a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b864552011d387dec4a6f254cfd43754
https://pubmed.ncbi.nlm.nih.gov/28475417
https://pubmed.ncbi.nlm.nih.gov/28475417
Autor:
Curtis Maier, James Green, Holly W. Smith, Dan Wierda, Gopi Shankar, Danuta J. Herzyk, Inge A. Ivens, Shalini Gupta, Leslie Abad, Lakshmi Amaravadi, Bonita Rup, Thomas Gelzleichter, Peter Thomas, Christopher Hurst, Rafael A. Ponce, Elizabeth R. Gore, Thomas T. Kawabata, Barbara Mounho
Publikováno v:
Regulatory Toxicology and Pharmacology. 54:164-182
An evaluation of potential antibody formation to biologic therapeutics during the course of nonclinical safety studies and its impact on the toxicity profile is expected under current regulatory guidance and is accepted standard practice. However, ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db21763a3b63644b6a26f232396a111
https://doi.org/10.1016/j.yrtph.2009.03.012
https://doi.org/10.1016/j.yrtph.2009.03.012
Autor:
Bruce D. Freedman, Michael I. Kotlikoff, Katsuyuki Yui, Brian Hondowicz, Curtis Maier, Andrew D. Wells, Qing-Hua Liu, Laurence A. Turka, Bernd K. Fleischmann
Publikováno v:
The Journal of Experimental Medicine
Ionic signaling pathways, including voltage-dependent potassium (Kv) channels, are instrumental in antigen-mediated responses of peripheral T cells. However, how Kv channels cooperate with other signaling pathways involved in T cell activation and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007e253b94cdd98222230c220c0cd825
https://doi.org/10.1084/jem.20020381
https://doi.org/10.1084/jem.20020381
Autor:
Danuta J. Herzyk, Louis Elefante, Ho Yen Sen, Trulli Stephen H, Kyung O. Johanson, Robert B. Kirkpatrick, Randall K. Johnson, Zdenka Ludmila Jonak, Yi-Jiun Chen, Curtis Maier, Francis L. McCabe, Michael T. Lotze
Publikováno v:
Journal of Immunotherapy. 25:S20-S27
Interleukin (IL)-18 has profound antitumor activity when administered at high doses as a single agent for prolonged periods in BALB/c mice bearing late, well-established MOPC-315 tumors. Management with a qD x 27 schedule resulted in regression of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2e81a9487a25b42fb7a628c2a7a84e
https://doi.org/10.1097/00002371-200203001-00004
https://doi.org/10.1097/00002371-200203001-00004