Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Curtis M, Tyree"'
Autor:
Jeffrey N. Miner, Yue Mao, Loan N. Miller, Michael A. Stashko, Michael J. Coghlan, Brian E. Green, Chun W. Lin, John K. Pratt, Masaki Nakane, Curtis M. Tyree, Ben Lane, David D. Anderson, Douglas H. Falls, Steven W. Elmore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1721-1727
The SAR at C-5 of the 10-methoxy-2,2,4-trimethylbenzopyrano[3,4-f]quinoline core leading to identification of (-) anti 1-methylcyclohexen-3-yl as the optimum substituent that imparts minimal GR mediated in vitro transcriptional activation while maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ef79125d6f7e59caf9712a9e11a80b
https://doi.org/10.1016/j.bmcl.2004.01.044
https://doi.org/10.1016/j.bmcl.2004.01.044
Autor:
Marc Elgort, Jeffrey N. Miner, Jay R. Luly, Philip R. Kym, Steven W. Elmore, George W. Carter, Curtis M. Tyree, Ben Lane, Chun Wei Lin, Michael J. Coghlan, Junlian Hu, Jon Rosen, Peer B. Jacobson, Russell T. Turner, Masaki Nakane
Publikováno v:
Molecular Endocrinology. 17:860-869
Glucocorticoids (GCs) are commonly used to treat inflammatory disease; unfortunately, the long-term use of these steroids leads to a large number of debilitating side effects. The antiinflammatory effects of GCs are a result of GC receptor (GR)-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7becbddb98014712fb5159bc83265f3
https://doi.org/10.1210/me.2002-0355
https://doi.org/10.1210/me.2002-0355
Autor:
Jeffery N. Miner, Chun W. Lin, Michael A. Stashko, Peer B. Jacobson, Masake Nakane, Philip R. Kym, Daniel P. Larson, Steven W. Elmore, H. Douglass Falls, Michael J. Coghlan, Loan N. Miller, Curtis M. Tyree, Jimmie L. Moore, Denise Wilcox, Rui Tang, Michael E. Kort, Benjamin C. Lane, Phong Nguyen, James D. Ratajczyk, John K. Pratt
Publikováno v:
Journal of Medicinal Chemistry. 46:1016-1030
The preparation and characterization of a series of C-10 substituted 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines as a novel class of selective ligands for the glucocorticoid receptor is described. Substitution at the C-10 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3260ef0df0e55a15e67ec5aae902de
https://doi.org/10.1021/jm020335m
https://doi.org/10.1021/jm020335m
Autor:
Keith B. Marschke, Elaine M. Berger, Jeffrey N. Miner, Curtis M. Tyree, Ben Lane, Jon Rosen, Dave Clemm, Masaki Nakane, Michael J. Coghlan, Junlian Hu
Publikováno v:
Molecular Endocrinology. 17:117-127
Selective intracellular receptor antagonists are used clinically to ameliorate hormone-dependent disease states. Patients with Cushing's syndrome have high levels of the glucocorticoid, cortisol, and suffer significant consequences from this overexpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60407bbf5efd894ead60e0cad983441
https://doi.org/10.1210/me.2002-0010
https://doi.org/10.1210/me.2002-0010
Publikováno v:
Journal of Biological Chemistry. 270:6292-6297
To study the mechanism of basal transcription by RNA polymerase II, a cDNA encoding the Drosophila homologue of the small subunit of TFIIF (also referred to as TFIIF30, RAP30, factor 5b, and gamma) was isolated. The Drosophila TFIIF30 gene is located
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37cf66dc086c2579c6ad7dc2c74d0f6
https://doi.org/10.1074/jbc.270.11.6292
https://doi.org/10.1074/jbc.270.11.6292
Autor:
Sangram S. Sisodia, Rudolph E. Tanzi, Chengzhi Yu, Anne M. Danks, Soan Cheng, Gonul Velicelebi, Kenneth A. Stauderman, Kwangwook Ahn, Yue-Ming Li, Elizabeth J. Ackerman, Dan Comer, Paul J. Digregorio, Phuong T. Nguyen, William T. Comer, Long Mao, David P. M. Pleynet, Xulun Zhang, Maria Z. Kounnas, Steven L. Wagner, William C. Mobley, Curtis M. Tyree
Alzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Abeta(42) levels without inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e0cce1c4de406c2d5b743c7ab53d04
https://europepmc.org/articles/PMC2947312/
https://europepmc.org/articles/PMC2947312/
Publikováno v:
Journal of Biological Chemistry. 265:21223-21231
We have subdivided the components of the basic RNA polymerase II machinery from Drosophila embryos into three fractions and RNA polymerase II. The RNA polymerase II was 90% homogeneous and possessed the IIa form of the largest subunit. By substitutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbea374249d5174d7e5b5ff53835325d
https://doi.org/10.1016/s0021-9258(17)45349-x
https://doi.org/10.1016/s0021-9258(17)45349-x
Autor:
Curtis M, Tyree, Kay, Klausing
Publikováno v:
Methods in molecular medicine. 85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3806db59a5937fe8dd987bf6b4284f63
https://pubmed.ncbi.nlm.nih.gov/12710208
https://pubmed.ncbi.nlm.nih.gov/12710208
Autor:
Mike Stashko, Loan N. Miller, Philip R. Kym, George W. Carter, Jane Kuk, Doug H. Falls, Masaki Nakane, Chun Wel Lin, Mike J. Coghlan, Jeffrey N. Miner, John Rosen, Ruth Huang, Curtis M. Tyree, Ben Lane
Publikováno v:
Molecular pharmacology. 62(2)
Glucocorticoids are potent anti-inflammatory and immunosuppressant agents. However, they also produce serious side effects that limit their usage. It has been proposed that anti-inflammatory properties of glucocorticoids are caused mostly by repressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46bc8f463c789a8941435e8774a1209
https://pubmed.ncbi.nlm.nih.gov/12130681
https://pubmed.ncbi.nlm.nih.gov/12130681
Autor:
Brian E. Green, Jeffery N. Miner, Curtis M. Tyree, Alan X. Wang, Michael A. Stashko, John K. Pratt, Peer B. Jacobson, Chun W. Lin, Michael J. Coghlan, David D. Anderson, Benjamin C. Lane, Denise Wilcox, Steven W. Elmore
Publikováno v:
Journal of medicinal chemistry. 44(25)
The preparation and characterization of a series of selective glucocorticoid receptor modulators are described. The preliminary structure-activity relationship of nonaromatic C-5 substitution on the tetracyclic quinoline core showed a preference for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858783f1851f007a7cf1c4565c1af741
https://pubmed.ncbi.nlm.nih.gov/11728194
https://pubmed.ncbi.nlm.nih.gov/11728194