Výsledky vyhledávání - "Curtis L. Franklin"

Erythrocyte Mean Corpuscular Volume as a Surrogate Marker for 6-Thioguanine Nucleotide Concentration Monitoring in Patients with Inflammatory Bowel Disease Treated with Azathioprine or 6-Mercaptopurine

Autor: James J. Lipsky, William J. Sandborn, Philip W. Lowry, Curtis L. Franklin, William J. Tremaine, Carlton W. Thomas, Dennis C. Mays, Amy L. Weaver, Gennett M. Myhre

Publikováno v: Inflammatory Bowel Diseases. 9:237-245

Mean corpuscular volume may correlate with erythrocyte 6-thioguanine nucleotide concentrations in patients treated with azathioprine and 6-mercaptourine. We conducted a study of 166 patients with inflammatory bowel disease treated with azathioprine o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cd64fc0ca3f292438e68aa127769b7
https://doi.org/10.1097/00054725-200307000-00004

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Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood

Autor: Curtis L. Franklin, Philip W. Lowry, M. Gennett Pike, James J. Lipsky, William J. Sandborn, Dennis C. Mays

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 757:1-9

The conversion of the cytotoxic and immunosuppressive 6-mercaptopurine (6MP) to the active 6-thioguanine nucleotides (6TGN) is necessary for clinical efficacy of 6MP and its prodrug azathioprine. Another metabolite, 6-methylmercaptopurine nucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa801767705c5372f287d24a34dbafe
https://doi.org/10.1016/s0378-4347(00)00513-2

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Thiopurine metabolites and the role of thiopurine methyltransferase activity in inflammatory bowel disease

Autor: Curtis L. Franklin, Amy L. Weaver, Dennis C. Mays, James J. Lipsky, W J Sandborn, Philip W. Lowry, M Gennett Pike, W.J. Tremaine

BACKGROUND—Measurement of 6-thioguanine nucleotide concentrations may be useful for optimising treatment with azathioprine and 6-mercaptopurine. METHODS—We conducted a study of 170 patients with inflammatory bowel disease treated with azathioprin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30760b9e8768b5daa467d1552843602
https://europepmc.org/articles/PMC1773292/

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Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide

Autor: Dennis C. Mays, Amy L. Weaver, Richard M. Weinshilboum, Carol L. Szumlanski, Philip W. Lowry, James J. Lipsky, William J. Sandborn, Edward V. Loftus, William J. Tremaine, Curtis L. Franklin

AIM—We evaluated the effect of coadministration of sulphasalazine, mesalamine, and balsalazide on the pharmacokinetics and pharmacodynamics of azathioprine and 6-mercaptopurine. METHODS—Thirty four patients with Crohn's disease receiving azathiop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae047baaec4e6a7589eb2aa59ca718e
https://europepmc.org/articles/PMC1728490/

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