Small angle X‐ray scattering‐assisted protein structure prediction in CASP13 and emergence of solution structure differences

Autor: Sergei Grudinin, Jose M. Duarte, Curtis D. Hodge, Dmytro Guzenko, John A. Tainer, Bohdan Monastyrskyy, Daniel J. Rosenberg, Susan E. Tsutakawa, Greg L. Hura, Krzysztof Fidelis, Andriy Kryshtafovych

Publikováno v: Proteins-Structure, Function and Bioinformatics
Proteins-Structure, Function and Bioinformatics, 2019, Critical Assessment of Methods of Protein Structure Prediction (CASP) Special Issue, 87 (12), pp.1298-1314. ⟨10.1002/prot.25827⟩
Proteins, vol 87, iss 12
Proteins
Proteins-Structure, Function and Bioinformatics, Wiley, 2019, Critical Assessment of Methods of Protein Structure Prediction (CASP) Special Issue, 87 (12), pp.1298-1314. ⟨10.1002/prot.25827⟩

International audience; Small angle X‐ray scattering (SAXS) measures comprehensive distance information on a protein's structure, which can constrain and guide computational structure prediction algorithms. Here, we evaluate structure predictions o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5b99340cac2b7dd0145f7892a96b29
https://inria.hal.science/hal-02315292

Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting

Autor: D McDonald, J. N. Glover, Msy Pulvino, J Zhao, Craig J. Markin, Curtis D. Hodge, Michael J. Hendzel, Msy Huen, Leo Spyracopoulos, Ross A. Edwards

Publikováno v: ACS Chemical Biology. 10:1718-1728

Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of Ubc13 with two inhibitors, NSC697923 and BAY 11-7082, which inhibit DNA damag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f85a9cfd0cb1ef77984bd394ba3376
https://doi.org/10.1021/acschembio.5b00222

RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment

Autor: Greg L. Hura, Ismail Hassan Ismail, John A. Tainer, Ross A. Edwards, Andrew T. Xiao, Michael J. Hendzel, Curtis D. Hodge, J. N. Mark Glover

Publikováno v: The Journal of biological chemistry, vol 291, iss 18
Hodge, CD; Ismail, IH; Edwards, RA; Hura, GL; Xiao, AT; Tainer, JA; et al.(2016). RNF8 E3 ubiquitin ligase stimulates Ubc13 E2 conjugating activity that is essential for DNA double strand break signaling and BRCA1 tumor suppressor recruitment. Journal of Biological Chemistry, 291(18), 9396-9410. doi: 10.1074/jbc.M116.715698. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/3sg7k2t8

DNA double strand break (DSB) responses depend on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-conjugating enzyme Ubc13 to specifically generate histone Lys-63-linked ubiquitin chains in DSB signaling. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99dfd53f8df5efefcb2cf42efba2140
https://escholarship.org/uc/item/3sg7k2t8

Phylogenetic analysis of the maternal genome of tetraploid StStYY Elymus (Triticeae: Poaceae) species and the monogenomic Triticeae based on rps16 sequence data

Autor: Huan Wang, Genlou Sun, Curtis D. Hodge

Publikováno v: Plant Science. 178:463-468

Although there have been several studies on the maternal genome donor of StStYY Elymus species, due to either the lack of inclusion of all the Triticeae diploid species or limited number of StY species used in the previous studies, it is necessary to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b5f532cd7acf66ad3a9d283f53dce1e
https://doi.org/10.1016/j.plantsci.2010.03.002