Zobrazeno 1 - 10
of 890
pro vyhledávání: '"Curtis C, Harris"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract Despite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore, exploring the effect of mutations on p53 isoforms activities is a critical, albeit unexplored area
Externí odkaz:
https://doaj.org/article/5366a9b27ccf491d81dd6ccae5616d55
Autor:
Joshua K. Stone, Natalia von Muhlinen, Chenran Zhang, Ana I. Robles, Amy L. Flis, Eleazar Vega-Valle, Akihiko Miyanaga, Masaru Matsumoto, K. Leigh Greathouse, Tomer Cooks, Giorgio Trinchieri, Curtis C. Harris
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-16 (2024)
Abstract Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and immunity in the tumor microenvironment, affecting growth and metastases. We previously characterized the lung cancer m
Externí odkaz:
https://doaj.org/article/cdfd8b5885b44df59ed98c80eee47052
Autor:
Yotsawat Pomyen, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Donlaporn Sripan, Chidchanok Chornkrathok, Anuradha Budhu, Vajarabhongsa Budhisawasdi, Nirush Lertprasertsuke, Anon Chotirosniramit, Chawalit Pairojkul, Chirayu U. Auewarakul, Teerapat Ungtrakul, Thaniya Sricharunrat, Kannikar Phornphutkul, Suleeporn Sangrajang, Christopher A. Loffredo, Curtis C. Harris, Chulabhorn Mahidol, Xin Wei Wang, Mathuros Ruchirawat, TIGER-LC Consortium
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Primary liver cancer (PLC), which includes intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC), has the highest incidence of all cancer types in Thailand. Known etiological factors, such as viral hepatitis and chronic l
Externí odkaz:
https://doaj.org/article/d955494aa8144bc898c80f8b0cf18c26
Autor:
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Non-enterotoxigenic Bacteroides fragilis (NTBF) is abundant in colorectal cancer (CRC) patients and in a high-fat diet (HFD)-induced CRC model. Here the authors show that bile salt hydrolase-expressing NTBF is enriched in CRC patients with overweight
Externí odkaz:
https://doaj.org/article/81ef42b6daf243ddb4b812fae07958c9
Autor:
Amelia L. Parker, Elise Bowman, Adriana Zingone, Brid M. Ryan, Wendy A. Cooper, Maija Kohonen-Corish, Curtis C. Harris, Thomas R. Cox
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-29 (2022)
Abstract Background Squamous cell carcinoma (SqCC) is a subtype of non-small cell lung cancer for which patient prognosis remains poor. The extracellular matrix (ECM) is critical in regulating cell behavior; however, its importance in tumor aggressiv
Externí odkaz:
https://doaj.org/article/33a960bc1cd646fea481743382d365e6
Autor:
Takahiro Oike, Naoto Osu, Yuya Yoshimoto, Hideru Obinata, Kazuhiro Yoshikawa, Curtis C. Harris, Tatsuya Ohno
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e16684- (2023)
This pilot study aimed primarily to evaluate plasma levels of a novel metabolite, creatine riboside, in patients with cervical cancer (discovery and validation cohorts, n = 11 for each) compared with non-cancer subjects (controls, n = 30). We found t
Externí odkaz:
https://doaj.org/article/411de5e1572c4040a062bc901d1a6104
Autor:
Bruna R. Muys, Roshan L. Shrestha, Dimitrios G. Anastasakis, Lorinc Pongor, Xiao Ling Li, Ioannis Grammatikakis, Ahsan Polash, Raj Chari, Myriam Gorospe, Curtis C. Harris, Mirit I. Aladjem, Munira A. Basrai, Markus Hafner, Ashish Lal
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112260- (2023)
Summary: Matrin3 is an RNA-binding protein that regulates diverse RNA-related processes, including mRNA splicing. Although Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we report Mat
Externí odkaz:
https://doaj.org/article/a88f2d3b066a45a5bbb59f4426f60a4b
Autor:
Alejandro A. Schäffer, Dana A. Dominguez, Lesley M. Chapman, E. Michael Gertz, Anuradha Budhu, Marshonna Forgues, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Xiaolin Wu, Enkhjargal Bayarsaikhan, Curtis C. Harris, Mathuros Ruchirawat, Eytan Ruppin, Xin Wei Wang
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Engineered versions of adeno-associated virus (AAV) are commonly used in gene therapy but evidence revealing a potential oncogenic role of natural AAV in hepatocellular carcinoma (HCC) has raised concerns. The frequency of potenti
Externí odkaz:
https://doaj.org/article/112941e99568473c8c4542fa2d87f042
Autor:
Amelia L. Parker, Leila Toulabi, Takahiro Oike, Yasuyuki Kanke, Daxeshkumar Patel, Takeshi Tada, Sheryse Taylor, Jessica A. Beck, Elise Bowman, Michelle L. Reyzer, Donna Butcher, Skyler Kuhn, Gary T. Pauly, Kristopher W. Krausz, Frank J. Gonzalez, S. Perwez Hussain, Stefan Ambs, Bríd M. Ryan, Xin Wei Wang, Curtis C. Harris
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
The metabolic dependencies of cancer cells have substantial potential to be exploited to improve the diagnosis and treatment of cancer. Creatine riboside (CR) is identified as a urinary metabolite associated with risk and prognosis in lung and liver
Externí odkaz:
https://doaj.org/article/cade40de76004f3eac0d8228a46781a4
Autor:
Akihiko Miyanaga, Masaru Matsumoto, Jessica A. Beck, Izumi Horikawa, Takahiro Oike, Hirokazu Okayama, Hiromi Tanaka, Sandra S. Burkett, Ana I. Robles, Mohammed Khan, Delphine Lissa, Masahiro Seike, Akihiko Gemma, Hiroyuki Mano, Curtis C. Harris
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-16 (2021)
Abstract Background Chromosomal inversions involving anaplastic lymphoma kinase (ALK) and echinoderm microtubule associated protein like 4 (EML4) generate a fusion protein EML4-ALK in non-small cell lung cancer (NSCLC). The understanding of EML4-ALK
Externí odkaz:
https://doaj.org/article/ee027c07a02f4bab814a420464192423