Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Curtis Balch"'
Autor:
Kenneth P. Nephew, Tim H-M. Huang, David G. Skalnik, Suzanne Young, Teresa Craft, Pearlly Yan, Curtis Balch
Supplemental Data from Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa02c3d30aa241ed89ce6821d0406ec
https://doi.org/10.1158/1535-7163.22484618
https://doi.org/10.1158/1535-7163.22484618
Autor:
Kenneth P. Nephew, Tim H-M. Huang, David G. Skalnik, Suzanne Young, Teresa Craft, Pearlly Yan, Curtis Balch
Deoxycytosine methylation within CpG islands of tumor suppressor genes plays a prominent role in the development and progression of drug-resistant ovarian cancer. Consequently, epigenetic therapies directed toward tumor suppressor demethylation/reexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398ecdcbd5e55736c25a10fe4a946a2e
https://doi.org/10.1158/1535-7163.c.6531491.v1
https://doi.org/10.1158/1535-7163.c.6531491.v1
Autor:
Kenneth P. Nephew, Tim H-M. Huang, Sun Kim, Robert Brown, Gillian Gifford, Beth Y. Karlan, Ramana V. Davuluri, Joseph C. Wan, Zailong Wang, Lang Li, Sandya Liyanarachchi, Rae Lynn Baldwin, Yoo-Sung Kim, Henry H. Paik, Curtis Balch, Susan H. Wei
Purpose: Aberrant DNA methylation, now recognized as a contributing factor to neoplasia, often shows definitive gene/sequence preferences unique to specific cancer types. Correspondingly, distinct combinations of methylated loci can function as bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a9a138d7db3e129e92095cb82de960
https://doi.org/10.1158/1078-0432.c.6518470.v1
https://doi.org/10.1158/1078-0432.c.6518470.v1
Autor:
Kenneth P. Nephew, Tim H.M. Huang, Curtis Balch, Kate M. Brannon, Adam Golas, Annie P. Moseman, Merrill J. Egorin, Eleanor G. Zuhowski, Milos Novotny, Jason A. Starkey, John S. Montgomery, Phillip H. Abbosh
Supplementary Figures S5-S7 from Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109a003215eaab96f0b7326863d750a1
https://doi.org/10.1158/0008-5472.22364520
https://doi.org/10.1158/0008-5472.22364520
Autor:
Kenneth P. Nephew, Tim H.M. Huang, Curtis Balch, Kate M. Brannon, Adam Golas, Annie P. Moseman, Merrill J. Egorin, Eleanor G. Zuhowski, Milos Novotny, Jason A. Starkey, John S. Montgomery, Phillip H. Abbosh
Histone modifications and DNA methylation are epigenetic phenomena that play a critical role in many neoplastic processes, including silencing of tumor suppressor genes. One such histone modification, particularly at H3 and H4, is methylation at spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c124f266d5e0e4f9d6ca451d00242a7
https://doi.org/10.1158/0008-5472.c.6494223
https://doi.org/10.1158/0008-5472.c.6494223
Autor:
Erika M. Kwon, David R. Jones, Patty L. Bonney, Kenneth P. Nephew, Zhongmin Guo, Deepika Dhawan, Curtis Balch, Fang Fang, Corie Hartman-Frey, Noah M. Hahn, Deborah W. Knapp, Heidi G. Parker, Elaine A. Ostrander
Publikováno v:
Journal of Urology. 187:302-309
We determined the efficacy, biological activity, pharmacokinetics and safety of the hypomethylating agent 5-azacitidine (Celgene Corp., Summit, New Jersey) in dogs with naturally occurring invasive urothelial carcinoma.We performed a preclinical phas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f0b37bad191226e2ad784b9ac8f162
https://doi.org/10.1016/j.juro.2011.09.010
https://doi.org/10.1016/j.juro.2011.09.010
Autor:
Curtis Balch, Kenneth P. Nephew
Publikováno v:
Cancer Biomarkers. 8:203-221
Summary: The term “epigenetics” refers to DNA sequence-independent events that regulate gene expression, including DNA methylation, modifications to histone proteins, and microRNA-associated post-transcriptional control of protein translation. Ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3545e1bb13f90faa474f99a0e3e1c4f
https://doi.org/10.3233/cbm-2011-0214
https://doi.org/10.3233/cbm-2011-0214
Autor:
Xiaoman Li, Wei Zhang, Sun Kim, Meiyun Fan, Jason D. Robarge, Ramana V. Davuluri, Alfred S. L. Cheng, Henry H. Paik, Victor X. Jin, Curtis Balch, Kenneth P. Nephew, Tim H M Huang, Lang Li
Publikováno v:
Bioinformatics. 22:2210-2216
Motivation: To detect and select patterns of transcription factor binding sites (TFBSs) which distinguish genes directly regulated by estrogen receptor-α (ERα), we developed an innovative mixture model-based discriminate analysis for identifying or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa139ae412b440f46906de37089621db
https://doi.org/10.1093/bioinformatics/btl329
https://doi.org/10.1093/bioinformatics/btl329
Autor:
Annie P. Moseman, Adam A. Golas, Curtis Balch, John S. Montgomery, Kenneth P. Nephew, Merrill J. Egorin, Eleanor G. Zuhowski, Milos V. Novotny, Phillip H. Abbosh, Tim H M Huang, Jason A. Starkey, Kate M. Brannon
Publikováno v:
Cancer Research. 66:5582-5591
Histone modifications and DNA methylation are epigenetic phenomena that play a critical role in many neoplastic processes, including silencing of tumor suppressor genes. One such histone modification, particularly at H3 and H4, is methylation at spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0ca3237af682108071a32c81eb8a11
https://doi.org/10.1158/0008-5472.can-05-3575
https://doi.org/10.1158/0008-5472.can-05-3575
Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer
Autor:
Teresa Craft, David G. Skalnik, Suzanne Young, Curtis Balch, Kenneth P. Nephew, Tim H M Huang, Pearlly S. Yan
Publikováno v:
Molecular Cancer Therapeutics. 4:1505-1514
Deoxycytosine methylation within CpG islands of tumor suppressor genes plays a prominent role in the development and progression of drug-resistant ovarian cancer. Consequently, epigenetic therapies directed toward tumor suppressor demethylation/reexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bad5258e61d9e8b9e408f5444871aad
https://doi.org/10.1158/1535-7163.mct-05-0216
https://doi.org/10.1158/1535-7163.mct-05-0216