Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Curtis A. Thorne"'
Autor:
Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
The incidence of early-onset colorectal cancer (EO-CRC) is rising and is poorly understood. Lifestyle factors and altered genetic background possibly contribute. Here, we performed targeted exon sequencing of archived leukocyte DNA from 158 EO-CRC pa
Externí odkaz:
https://doaj.org/article/3c6bd39e8751433aa3ebb5c0d90e69a7
Autor:
Elaine C. Chen, Pavlo Gilchuk, Seth J. Zost, Naveenchandra Suryadevara, Emma S. Winkler, Carly R. Cabel, Elad Binshtein, Rita E. Chen, Rachel E. Sutton, Jessica Rodriguez, Samuel Day, Luke Myers, Andrew Trivette, Jazmean K. Williams, Edgar Davidson, Shuaizhi Li, Benjamin J. Doranz, Samuel K. Campos, Robert H. Carnahan, Curtis A. Thorne, Michael S. Diamond, James E. Crowe, Jr.
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109604- (2021)
Summary: Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases, as well as healthy individuals. Here we identify 37 public clonotypes
Externí odkaz:
https://doaj.org/article/b641b5a3e5504c6aba50fe6b796af664
Autor:
Jayati Chakrabarti, Ritu Pandey, Jared M. Churko, Jennifer Eschbacher, Saptarshi Mallick, Yuliang Chen, Beth Hermes, Palash Mallick, Ben N. Stansfield, Kelvin W. Pond, Curtis A. Thorne, Kevin C. J. Yuen, Andrew S. Little, Yana Zavros
Publikováno v:
Cells, Vol 11, Iss 21, p 3344 (2022)
(1) Background: Cushing’s disease (CD) is a serious endocrine disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumor (PitNET) that stimulates the adrenal glands to overproduce cortisol. Chronic exposure to
Externí odkaz:
https://doaj.org/article/654d70ac56184aceb382ca726ba56b25
Autor:
Jijun Hao, Ada Ao, Li Zhou, Clare K. Murphy, Audrey Y. Frist, Jessica J. Keel, Curtis A. Thorne, Kwangho Kim, Ethan Lee, Charles C. Hong
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 898-904 (2013)
The canonical Wnt signaling pathway, mediated by the transcription factor β-catenin, plays critical roles in embryonic development and represents an important therapeutic target. In a zebrafish-based in vivo screen for small molecules that specifica
Externí odkaz:
https://doaj.org/article/c65b8a96757843c4ba6156e64d153833
Gene regulatory networks, which control gene expression patterns in development and in response to stimuli, use regulatory logic modules to coordinate inputs and outputs. One example of a regulatory logic module is the gene regulatory cascade (GRC),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1110c98c199b3835294210a6f712ffee
https://doi.org/10.1101/2023.05.08.539911
https://doi.org/10.1101/2023.05.08.539911
Autor:
Kathleen A. Lasick, Elizabeth Jose, Allison M. Samayoa, Lisa Shanks, Kelvin W. Pond, Curtis A. Thorne, Andrew L. Paek
Publikováno v:
Molecular Biology of the Cell. 34
Both H2O2 and serum starvation activate FOXO transcription factors, but they lead to different FOXO-induced cell outcomes. Here we find a link between the dynamics of FOXO activation and cell fate. H2O2 induces sustained nuclear FOXO, which is linked
Autor:
Sara Kassel, Alison J. Hanson, Hassina Benchabane, Kenyi Saito-Diaz, Carly R. Cabel, Lily Goldsmith, Muhammad Taha, Aksheta Kanuganti, Victoria H. Ng, George Xu, Fei Ye, Julia Picker, Fillip Port, Michael Boutros, Vivian L. Weiss, David J. Robbins, Curtis A. Thorne, Yashi Ahmed, Ethan Lee
Publikováno v:
Science Signaling. 16
The Wnt–β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt signaling converts TCF from a transcriptional repressor to an activator in a process facilitated by the E3 ligase XIAP. XIAP-med
Autor:
Mary Jo Cantoria, Elaheh Alizadeh, Janani Ravi, Reeba P. Varghese, Nawat Bunnag, Kelvin W. Pond, Arminja N. Kettenbach, Yashi Ahmed, Andrew L. Paek, John J. Tyson, Konstantin Doubrovinski, Ethan Lee, Curtis A. Thorne
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Wnt ligands are considered classical morphogens, for which the strength of the cellular response is proportional to the concentration of the ligand. Herein, we show an emergent property of bistability arising from feedback among the Wnt destruction c
Autor:
Abigail Camenisch, Isabella R. Blum, Stefanie A.T. Mitchell, Meng-Han Wu, Christopher M. Cox, Matthew T Ollerton, Pawel R. Kiela, Marco Padilla-Rodriguez, Vanessa Figliuolo da Paz, John Muller, Curtis A. Thorne, Jean M. Wilson, Samina Momtaz
Publikováno v:
Dev Biol
During postnatal intestinal development, the intestinal epithelium is highly proliferative, and this proliferation is regulated by signaling in the intervillous and crypt regions. This signaling is primarily mediated by Wnt, and requires membrane tra
Autor:
A Papi, Joshua Malo, L Shuaizhi, Scott D. Lick, Carly R. Cabel, Francesca Polverino, Curtis A. Thorne, Fernando D. Martinez, Julie G. Ledford, Marco Contoli, Joselyn Rojas-Quintero, Simonetta Baraldo, Monica Kraft, J Mayo, David A. Bull, Samuel K. Campos, Farrah Kheradmand, J Tram, M Tomchaney, S Knoper, Yohannes Tesfaigzi, S S Kim
Publikováno v:
BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-14 (2021)
bioRxiv
BMC Pulmonary Medicine
bioRxiv
BMC Pulmonary Medicine
IntroductionHow cigarette smoke (CS) and chronic obstructive pulmonary disease (COPD) affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severity is controversial. We investigated the protein and mRNA expression of SARS