Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Curtis, Dobrowolski"'
Autor:
Samira Joussef-Piña, Immaculate Nankya, Sophie Nalukwago, Joy Baseke, Sandra Rwambuya, Dane Winner, Fred Kyeyune, Keith Chervenak, Bonnie Thiel, Robert Asaad, Curtis Dobrowolski, Benjamin Luttge, Blair Lawley, Cissy M. Kityo, W. Henry Boom, Jonathan Karn, Miguel E. Quiñones-Mateu
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-20 (2022)
Abstract Background Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B HIV-1 strains, with only limited information available from patients infected with non-B HIV-1 subtypes
Externí odkaz:
https://doaj.org/article/8163d2795d46469d98e497b22a223b34
Autor:
Kien Nguyen, Curtis Dobrowolski, Meenakshi Shukla, Won-Kyung Cho, Benjamin Luttge, Jonathan Karn
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1010014 (2021)
One strategy for a functional cure of HIV-1 is "block and lock", which seeks to permanently suppress the rebound of quiescent HIV-1 by epigenetic silencing. For the bivalent promoter in the HIV LTR, both histone 3 lysine 27 tri-methylation (H3K27me3)
Externí odkaz:
https://doaj.org/article/978c6c5fe8664892ac69b57b94c08f28
Autor:
Afsane Radmand, Melissa P. Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G. Huayamares, Marine Z. C. Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J. Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nano Letters. 23:993-1002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee5f3aad88116eea784f435311926c8
https://doi.org/10.1021/acs.nanolett.2c04479
https://doi.org/10.1021/acs.nanolett.2c04479
Autor:
Curtis Dobrowolski, Kalina Paunovska, Elisa Schrader Echeverri, David Loughrey, Alejandro J. Da Silva Sanchez, Huanzhen Ni, Marine Z. C. Hatit, Melissa P. Lokugamage, Yanina Kuzminich, Hannah E. Peck, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Nanotechnology. 17:871-879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5beb6a4306e31071e6b7bc2c2cb6f282
https://doi.org/10.1038/s41565-022-01146-9
https://doi.org/10.1038/s41565-022-01146-9
Autor:
Alejandro J. Da Silva Sanchez, Curtis Dobrowolski, Ana Cristian, Elisa Schrader Echeverri, Kun Zhao, Marine Z. C. Hatit, David Loughrey, Kalina Paunovska, James E. Dahlman
Publikováno v:
Nano Letters. 22:4822-4830
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae21db2cb5a0b7c56bef6f97b4676fa
https://doi.org/10.1021/acs.nanolett.2c01133
https://doi.org/10.1021/acs.nanolett.2c01133
Autor:
Curtis Dobrowolski, Saba Valadkhan, Amy C. Graham, Meenakshi Shukla, Angela Ciuffi, Amalio Telenti, Jonathan Karn
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The latent HIV reservoir is generated following HIV infection of activated effector CD4 T cells, which then transition to a memory phenotype. Here, we describe an ex vivo method, called QUECEL (quiescent effector cell latency), that mimics t
Externí odkaz:
https://doaj.org/article/541cf5d704a04c64a04abd20056f291a
Autor:
Jeffrey S. Miller, Zachary B. Davis, Erika Helgeson, Cavan Reilly, Ann Thorkelson, Jodi Anderson, Noemia S. Lima, Siri Jorstad, Geoffrey T. Hart, John H. Lee, Jeffrey T. Safrit, Hing Wong, Sarah Cooley, Lavina Gharu, Hyunsoo Chung, Patrick Soon-Shiong, Curtis Dobrowolski, Courtney V. Fletcher, Jonathan Karn, Daniel C. Douek, Timothy W. Schacker
Publikováno v:
Nature Medicine. 28:392-400
There is no cure for HIV infection, and lifelong antiretroviral therapy (ART) is required. N-803 is an IL-15 superagonist comprised of an N72D mutant IL-15 molecule attached to its alpha receptor and a human IgG1 fragment designed to increase IL-15 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25f9b3671f9c6c78a6829d80a5a5220
https://doi.org/10.1038/s41591-021-01651-9
https://doi.org/10.1038/s41591-021-01651-9
Autor:
Mary Ann Checkley, Benjamin G. Luttge, Curtis Dobrowolski, David N. Wald, Deborah McMahon, Ghady Haidar, Michele D. Sobolewski, P. Nathan Enick, Joshua Cyktor, John W. Mellors, Jonathan Karn
Treatment with latency-reversing agents (LRAs) alone has been ineffective in reducing HIV-1 reservoirs in persons with HIV-1 (PWH) on antiretroviral therapy (ART), due to inefficiencies in reservoir reactivation and adaptive immune responses. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe83ac9c1d4981b9c3f9a34df02c8a6
https://doi.org/10.1101/2022.09.05.506592
https://doi.org/10.1101/2022.09.05.506592
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells. Here we show, by u
Externí odkaz:
https://doaj.org/article/42bc129c3b064471b3b996f5b6bbbf29
Autor:
Sara Gianella, Stephen A Rawlings, Curtis Dobrowolski, Masato Nakazawa, Antoine Chaillon, Matthew Strain, Laura Layman, Gemma Caballero, Eileen Scully, Brianna Scott, Caitleen Pacis, Kathleen M Weber, Alan Landay, Christy Anderson, Jonathan Karn
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 75, iss 1
Clin Infect Dis
Clin Infect Dis
Background Sex differences in human immunodeficiency virus (HIV) reservoir dynamics remain underexplored. Methods Longitudinal samples from virally suppressed midlife women (n = 59, median age 45 years) and age-matched men (n = 31) were analyzed retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdda21e37b9110ff83f4e4547a64c05
https://escholarship.org/uc/item/8939r3qr
https://escholarship.org/uc/item/8939r3qr