Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Curt S. Cooper"'
Asymmetric dipolar cycloaddition reactions: a practical, convergent synthesis of chiral pyrrolidines
Autor:
Daniel T. W. Chu, Curt S. Cooper, Frederick Plagge, Sanyi Wang, Anthony K.L. Fung, John K. Lynch, Zhenkun Ma
Publikováno v:
Tetrahedron: Asymmetry. 8:883-887
Chiral trans-3,4-disubstituted pyrrolidines were obtained from the 1,3-dipolar cycloaddition of chiral α,β-unsaturated N-acyloxazolidinones and azomethine ylide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a1909489b918e1900ca8671ba055ca5
https://doi.org/10.1016/s0957-4166(97)00049-9
https://doi.org/10.1016/s0957-4166(97)00049-9
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:1307-1315
Two series of conformationally restricted quinolone antibacterials were synthesized. One series was restricted by formation of a tetrahydrofuran ring between the C-6 position and the C-7 position of the quinolone ring skeleton. The second series achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e5e755c83e29bec9191f55c63da5bf
https://doi.org/10.1016/0968-0896(96)00106-x
https://doi.org/10.1016/0968-0896(96)00106-x
Autor:
D. J. Hardy, Daniel T. W. Chu, Robert N. Swanson, Curt S. Cooper, Pamela L. Klock, J. J. Plattner
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3000a060de914a5ac6b0f7f0388fff4
https://doi.org/10.1002/chin.199301194
https://doi.org/10.1002/chin.199301194
Autor:
Curt S. Cooper, Anthony K.L. Fung, Zhenkun Ma, Daniel T. W. Chu, Sanyi Wang, Frederick Plagge, John K. Lynch
Publikováno v:
ChemInform. 28
Chiral trans-3,4-disubstituted pyrrolidines were obtained from the 1,3-dipolar cycloaddition of chiral α,β-unsaturated N-acyloxazolidinones and azomethine ylide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a7ccb392d11c026e799a132ff4cb18
https://doi.org/10.1002/chin.199731109
https://doi.org/10.1002/chin.199731109
Publikováno v:
Journal of Medicinal Chemistry. 33:1246-1252
A series of 6-fluoro-7-substituted-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids were prepared. The substituents at the 7-position included five- and six-membered heterocyclic rings such as oxazoline and oxazine as well as five-membered heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96abc7bf119509e1233e5fa11ccac4e
https://doi.org/10.1021/jm00166a025
https://doi.org/10.1021/jm00166a025
Autor:
Qun Li, Daniel T. W. Chu, Akiyo Claiborne, Curt S. Cooper, Cheuk M. Lee, Kathleen Raye, Kristine B. Berst, Pamela Donner, Weibo Wang, Lisa Hasvold, Anthony Fung, Zhenkun Ma, Michael Tufano, Robert Flamm, Linus L. Shen, John Baranowski, Angela Nilius, Jeff Alder, Jonathan Meulbroek, Kennan Marsh, DeAnne Crowell, Yuhua Hui, Louis Seif, Laura M. Melcher, Rodger Henry, Steven Spanton, Ramin Faghih, Larry L. Klein, S. Ken Tanaka, Jacob J. Plattner
Publikováno v:
Journal of medicinal chemistry. 39(16)
Two novel series of 2-pyridones were synthesized by transposition of the nitrogen of 4-quinolones to the bridgehead position. This subtle interchange of the nitrogen atom with a carbon atom yielded two novel heterocyclic nuclei, pyrido[1,2-alpha]pyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a50a29d2238b79a28999613a1a9301d
https://pubmed.ncbi.nlm.nih.gov/8759628
https://pubmed.ncbi.nlm.nih.gov/8759628
Autor:
Dwight J. Hardy, Daniel T. W. Chu, Robert N. Swanson, Curt S. Cooper, Pamela L. Klock, Jacob J. Plattner
Publikováno v:
Journal of medicinal chemistry. 35(8)
A series of quinolones were prepared which contained oximes or substituted oximes as replacements for the amine substituents normally found on the pyrrolidine or piperidine fragments of quinolone antibacterial agents. These substituents led to compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb32b4be01513e69098ef6c7989b79c4
https://pubmed.ncbi.nlm.nih.gov/1573632
https://pubmed.ncbi.nlm.nih.gov/1573632
Publikováno v:
ChemInform. 21
A series of 6-fluoro-7-substituted-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids were prepared. The substituents at the 7-position included five- and six-membered heterocyclic rings such as oxazoline and oxazine as well as five-membered heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b106da7408dd6ac98484fc7dc8eab786
https://doi.org/10.1002/chin.199048174
https://doi.org/10.1002/chin.199048174
Autor:
Ronald D. Snyder, Curt S. Cooper
Publikováno v:
Photochemistry and Photobiology. 69:288
The Chinese hamster V79 lung cell in vitro micronucleus assay was adapted to detect and quantify phototoxicity and photogenotoxicity of fluoroquinolones. Using this assay, the quinolones were ranked in terms of decreasing phototoxicity: clinafloxacin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b7957d597e23ad74a0134f352f4aa8
https://doi.org/10.1562/0031-8655(1999)069<0288:pofich>2.3.co
https://doi.org/10.1562/0031-8655(1999)069<0288:pofich>2.3.co
Autor:
Curt S. Cooper, Robert J. Weinkam
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 21:925-936
A method for the preparation of deuterium labelled unsymmetrical hydrazines was developed. This method was used to prepare l-benzyl-2-methyl-2H3-hydrazine hydrobromide and l-benzyl-2H7-2-methylhydrazine hydrobromide, analogs of the cancer chemotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d6d9cfd497463d4517aab1778fc4567
https://doi.org/10.1002/jlcr.2580211007
https://doi.org/10.1002/jlcr.2580211007