Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Curt R. Fischer"'
Autor:
Kali M. Pruss, Haoqing Chen, Yuanyuan Liu, William Van Treuren, Steven K. Higginbottom, John B. Jarman, Curt R. Fischer, Justin Mak, Beverly Wong, Tina M. Cowan, Michael A. Fischbach, Justin L. Sonnenburg, Dylan Dodd
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here, using a mouse model, the authors report a previously undescribed role for medium-chain acyl-CoA dehydrogenase in host metabolism of gut microbiota metabolites, and show that circulating compounds, including the abundant organic acid hippurate,
Externí odkaz:
https://doaj.org/article/14334ccffc5848da904c149209a88138
Autor:
Adam M. Wawro, Chandresh R. Gajera, Steven A. Baker, Robert K. Leśniak, Curt R. Fischer, Nay L. Saw, Mehrdad Shamloo, Thomas J. Montine
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Imbalance of excitatory and inhibitory neurotransmission is implicated in a wide range of psychiatric and neurologic disorders. Here we tested the hypothesis that insertion of a methyl group on the stereogenic alpha carbon of l-Glu or l-Gln
Externí odkaz:
https://doaj.org/article/0b1cf771b7094dddbe45b3302eac42de
Publikováno v:
eLife, Vol 9 (2020)
The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 (p
Externí odkaz:
https://doaj.org/article/462d15a66410454b9773bc0ee1e2b729
Autor:
Kali M. Pruss, Fatima Enam, Eric Battaglioli, Mary DeFeo, Oscar R. Diaz, Steven K. Higginbottom, Curt R. Fischer, Andrew J. Hryckowian, William Van Treuren, Dylan Dodd, Purna Kashyap, Justin L. Sonnenburg
Publikováno v:
Nature Metabolism
The enteric pathogen Clostridioides difficile (Cd) is responsible for a toxin-mediated infection that causes more than 200,000 recorded hospitalizations and 13,000 deaths in the United States every year1. However, Cd can colonize the gut in the absen
Autor:
Robert K Leśniak, Steven Andrew Baker, Curt R. Fischer, Nay L. Saw, Kathleen S. Montine, Thomas J. Montine, Adam M. Wawro, Mehrdad Shamloo, Chandresh R. Gajera
Publikováno v:
Journal of Neurochemistry. 158:1074-1082
Imbalance in the metabolic pathway linking excitatory and inhibitory neurotransmission has been implicated in multiple psychiatric and neurologic disorders. Recently, we described enantiomer-specific effects of 2-methylglutamate, which is not decarbo
Autor:
Juan M. Sanchez, Bryan D. Merrill, Shuo Han, Lalla A. Fall, Michael A. Fischbach, Brian C. DeFelice, Curt R. Fischer, Steven K. Higginbottom, Justin L. Sonnenburg, Dylan Dodd, Will Van Treuren, Leah Guthrie
Publikováno v:
Nature. 595:415-420
Gut microorganisms modulate host phenotypes and are associated with numerous health effects in humans, ranging from host responses to cancer immunotherapy to metabolic disease and obesity. However, difficulty in accurate and high-throughput functiona
Autor:
Steven Andrew Baker, Mehrdad Shamloo, Thomas J. Montine, Adam M. Wawro, Robert K Leśniak, Curt R. Fischer, Nay L. Saw, Chandresh R. Gajera
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Imbalance of excitatory and inhibitory neurotransmission is implicated in a wide range of psychiatric and neurologic disorders. Here we tested the hypothesis that insertion of a methyl group on the stereogenic alpha carbon of l-Glu or l-Gln would imp
Autor:
Michael A. Fischbach, Steven K. Higginbottom, Shuo Han, Lalla A. Fall, Curt R. Fischer, Justin L. Sonnenburg, Dylan Dodd, Bryan D. Merrill, Brian C. DeFelice, J. M. Sanchez, Leah Guthrie, W. Van Treuren
Gut microbes modulate host phenotypes and are associated with numerous health effects in humans, ranging from cancer immunotherapy response to metabolic disease and obesity. However, difficulty in accurate and high-throughput functional analysis of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810e0dbc755ce8bcdbb22e2641ce815f
https://doi.org/10.1101/2021.05.25.445684
https://doi.org/10.1101/2021.05.25.445684
Autor:
Chaitan Khosla, William L Fitch, Camilla M. Kao, Curt R. Fischer, Brad A. Palanski, Abrahim El Gamal, Karthik Sankaranarayanan, Xirui X Antaris
Publikováno v:
Journal of the American Chemical Society. 141:9474-9478
The Lipid A family of glycolipids, found in the outer membranes of all Gram-negative bacteria, exhibits considerable structural diversity in both lipid and glycan moieties. The lack of facile methods to prepare analogues of these natural products rep
Autor:
Neil K. Garg, Man-Cheng Tang, Dan Tan, Zhuan Zhang, Molly Miranda, Yi Tang, Robert P. St.Onge, Curt R. Fischer, Angela Chu, Jason V. Chari, Justin D. Smith, Sundari Suresh
Publikováno v:
J Am Chem Soc
Fungal highly reducing polyketide synthases (HRPKSs) biosynthesize polyketides using a single set of domains iteratively. Product release is a critical step in HRPKS function to ensure timely termination and enzyme turnover. Nearly all of the HRPKSs