Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Curt Malmsten"'
Publikováno v:
Biochemical and Biophysical Research Communications. 99:976-986
A preparation of human leukocytes was incubated with arachidonic acid. Two new dihydroxy acids with conjugated triene structures, were isolated and characterized as 8,15-dihydroxy-5,9,11,13-eicosatetraenoic acid (8,15-leukotriene B4) and 14,15-dihydr
Autor:
O Rådmark, Curt Malmsten, Ira M. Goldstein, Bengt Samuelsson, Gerald Weissmann, H Kindahl, Howard B. Kaplan
Publikováno v:
The Journal of Experimental Medicine
Human peripheral blood polymorphonuclear leukocytes were stimulated to generate thromboxane B2 in a time- and concentration-dependent fashion upon exposure to serum-treated zymosan particles. Conversion by stimulated PMN of [14C] arachidonic acid to
Autor:
Olof Rådmark, J A Lindgren, Bertil Samuelsson, J Palmblad, Udén Am, Curt Malmsten, Göran K. Hansson, Jubiz W
Publikováno v:
Journal of Biological Chemistry. 257:6106-6110
Stimulation of human polymorphonuclear leukocytes with the chemotactic peptide formylmethionylleucylphenylalanine led to the formation of a novel leukotriene: 5(S),12(R)-dihydroxy-6,8,10,14-eicosatetraen-1,20-dioic acid. This dihydroxydicarboxylic ac
Publikováno v:
Proceedings of the National Academy of Sciences. 72:3355-3358
The 9,11-azo-prostanoid III [(5Z, 9alpha, 11alpha, 13E, 15S)-9, 11-azo-15-hydroxyprosta-5,13-dienoic acid] has been obtained by synthesis and tested for biological activity in systems which are responsive to the prostaglandin endoperoxides PGH2 (I) a
Publikováno v:
Biochemical and Biophysical Research Communications. 96:1679-1687
An unstable epoxide, leukotriene A4 (5(S)- trans -5,6-oxido-7,9- trans -11,14- cis -eicosatetraenoic acid), was earlier proposed to be an intermediate in the conversion of arachidonic acid into the slow reacting substance (SRS), leukotriene C4. In th
Publikováno v:
British Journal of Haematology. 35:511-520
Thromboxane (TX) synthesis was investigated in some characterized platelet disorders and correlated with release of ADP or [14C]serotonin and platelet aggregation. In a case with Bernard-Soulier syndrome TX-synthesis as well as ADP-[14C]serotonin rel
Autor:
Anthony Marfat, David A. Clark, Olof Rådmark, Curt Malmsten, Giichi Goto, Bengt Samuelsson, E. J. Corey
Publikováno v:
Biochemical and Biophysical Research Communications. 92:954-961
Leukotriene A was assigned the structure 5(S)- trans -5,6-oxido-7,9- trans -11,14- cis -eicosatetraenoic acid by the enzymatic conversion of a synthetic product of known stereochemistry into the naturally occurring isomer of 5(S),12(R)-dihydroxy-6,8,
Publikováno v:
Blood. 58:658-661
We studied the effects of leukotrienes on in vitro functions of neutrophil polymorphonuclear (PMN) granulocytes. Leukotriene B4 (LTB4) evoked a stimulated and directed migration of neutrophils under agarose with an optimum concentration of 10(-6)M, w
Autor:
Hans-Erik Claesson, Curt Malmsten
Publikováno v:
European Journal of Biochemistry. 76:277-284
The prostaglandin endoperoxide Gz caused rapid aggregation and release of ADP and [14C]serotonin in human platelets. Since the presence of the ADP phosphorylating system creatine phosphate/ creatine phosphokinase markedly inhibited the aggregation ca
Publikováno v:
Prostaglandins and Medicine. 4:453-463
13,14-Dehydro PGI2 (dh-PGI2) and 13,14-dehydro PGI2 methyl ester (dh-PGI2-Me) inhibited platelet aggregation and release of [14C]-serotonin and ADP induced by collagen, ADP, arachidonic acid and PGG2. The inhibitory dose (ID50) ofg dh-PGI2-Me on plat