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Trabectedin promotes oncolytic virus antitumor efficacy, viral gene expression, and immune effector function in models of bone sarcoma.

Autor: Ringwalt EM; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA., Currier MA; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Glaspell AM; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Chen CY; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Cannon MV; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Cam M; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43215, USA., Gross AC; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Gust M; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Wang PY; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Boon L; JJP Biologics, 00-728 Warsaw, Poland., Biederman LE; Department of Pathology, Nationwide Children's Hospital, Columbus, OH 43205, USA.; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Schwarz E; Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Rajappa P; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Department of Pediatrics and Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA., Lee DA; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Mardis ER; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA., Carson WE; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.; Department of Surgery, Division of Surgical Oncology, The Ohio State University, Columbus, OH 43210, USA., Roberts RD; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Cripe TP; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

Publikováno v: Molecular therapy. Oncology [Mol Ther Oncol] 2024 Sep 26; Vol. 32 (4), pp. 200886. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).

Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors.

Autor: Paudel SN; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Hutzen BJ; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Miller KE; Institute for Genomic Medicine, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.; Department of Pediatrics, The Ohio State University Wexner College of Medicine, Columbus, OH, United States., Garfinkle EAR; Institute for Genomic Medicine, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Chen CY; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Wang PY; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Glaspell AM; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Currier MA; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Ringwalt EM; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Boon L; JJP Biologics, Warsaw, Poland., Mardis ER; Institute for Genomic Medicine, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.; Department of Pediatrics, The Ohio State University Wexner College of Medicine, Columbus, OH, United States., Cairo MS; Department of Pediatrics, Medicine, Pathology, Microbiology and Immunology, and Cell Biology, New York Medical College, Valhalla, NY, United States., Ratner N; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States., Dodd RD; Department of Internal Medicine, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, United States., Cassady KA; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.; Department of Pediatrics, The Ohio State University Wexner College of Medicine, Columbus, OH, United States., Cripe TP; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.; Department of Pediatrics, The Ohio State University Wexner College of Medicine, Columbus, OH, United States.; Division of Pediatric Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Jun 25; Vol. 15, pp. 1384623. Date of Electronic Publication: 2024 Jun 25 (Print Publication: 2024).