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Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.

Autor: Gharahkhani P; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. 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Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Hamel AR; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Igo RP Jr; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Choquet H; Division of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA, USA., Qassim A; Department of Ophthalmology, Flinders University, Bedford Park, SA, Australia., Josyula NS; Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA., Cooke Bailey JN; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Bonnemaijer PWM; Depatment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; The Rotterdam Eye Hospital, Rotterdam, The Netherlands., Iglesias A; Depatment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands., Siggs OM; Department of Ophthalmology, Flinders University, Bedford Park, SA, Australia., Young TL; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Thiadens AAHJ; Depatment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Karjalainen J; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Uebe S; 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RIKEN Center for Advanced Intelligence Project, 1-4-1 Nihonbashi, Chuo-ku, Tokyo, Japan., Shiga Y; Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan., Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan., Nakazawa T; Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.; Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.; Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan., Currant H; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK., Birney E; 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Publikováno v: Nature communications [Nat Commun] 2021 Feb 24; Vol. 12 (1), pp. 1258. Date of Electronic Publication: 2021 Feb 24.