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Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies against Encapsulated Protein Antigen in Young Naïve Mice after Respiratory Immunization.

Autor: Parriott JE; Department of Pharmaceutical Sciences, College of Pharmacy, 986020 University of Nebraska Medical Center, Omaha, NE 68198, USA., Stewart JP; Department of Pharmaceutical Sciences, College of Pharmacy, 986020 University of Nebraska Medical Center, Omaha, NE 68198, USA., Smith DD; Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA., Curran SM; Department of Pharmaceutical Sciences, College of Pharmacy, 986020 University of Nebraska Medical Center, Omaha, NE 68198, USA., Bauer CD; Research Service, Department of Veterans Affairs Omaha-Western Iowa Health Care System, Omaha, NE 68105, USA.; Pulmonary, Critical Care and Sleep, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA., Wyatt TA; Research Service, Department of Veterans Affairs Omaha-Western Iowa Health Care System, Omaha, NE 68105, USA.; Pulmonary, Critical Care and Sleep, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE 68198, USA., Phillips JA; Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA 92182, USA., Lyden E; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA., Thiele GM; Research Service, Department of Veterans Affairs Omaha-Western Iowa Health Care System, Omaha, NE 68105, USA.; Department of Internal Medicine, Division of Rheumatology & Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA., Vetro JA; Department of Pharmaceutical Sciences, College of Pharmacy, 986020 University of Nebraska Medical Center, Omaha, NE 68198, USA.; Center for Drug Delivery and Nanomedicine, 985830 University of Nebraska Medical Center, Omaha, NE 68198, USA.

Publikováno v: Pharmaceutics [Pharmaceutics] 2022 Sep 01; Vol. 14 (9). Date of Electronic Publication: 2022 Sep 01.