Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cunnigaiper D. Bhanumathy"'
Publikováno v:
Journal of Biological Chemistry. 287:43674-43684
We have combined alanine mutagenesis and functional assays to identify amino acid residues in the channel domain that are critical for inositol 1,4,5-trisphosphate receptor (IP(3)R) channel function. The residues selected were highly conserved in all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34cb99ea6579fccea019c52db714869
https://doi.org/10.1074/jbc.m112.415786
https://doi.org/10.1074/jbc.m112.415786
Autor:
Donald L. Gill, Michael F. Ritchie, Cunnigaiper D. Bhanumathy, Yu Chin Lien, Suresh K. Joseph, Tomohiro Kurosaki, Yoshihiro Baba, Brian J. Hawkins, Jonathan Soboloff, Muniswamy Madesh, Ramasamy Subbiah, Youjun Wang, Krishna M. Irrinki, Karthik Mallilankaraman
Publikováno v:
The Journal of Cell Biology
Oxidant stress induces constitutive calcium entry by tacking glutathiones onto the Orai CRAC channel activator STIM1.
Oxidant stress influences many cellular processes, including cell growth, differentiation, and cell death. A well-recognized li
Oxidant stress influences many cellular processes, including cell growth, differentiation, and cell death. A well-recognized li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f55bdcbb509ae47e23cf3aa9e66a129
https://doi.org/10.1083/jcb.201004152
https://doi.org/10.1083/jcb.201004152
Publikováno v:
Journal of Biological Chemistry. 281:3722-3730
myo-Inositol 1,4,5-trisphosphate receptor (IP3R) degradation occurs in response to carbachol (Cch) stimulation of CHO-K1 cells. The response was mediated by endogenous muscarinic receptors and was blocked by atropine or proteasomal inhibitors. We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae1ad96c49716bff2d659a94b596f59
https://doi.org/10.1074/jbc.m509966200
https://doi.org/10.1074/jbc.m509966200
Autor:
Kumar Sharma, Aron B. Fisher, Satish P. RamachandraRao, Suresh K. Joseph, Muniswamy Madesh, Brian J. Hawkins, Tatyana N. Milovanova, Cunnigaiper D. Bhanumathy, Tomohiro Kurosaki
Publikováno v:
The Journal of Cell Biology
Reactive oxygen species (ROS) play a divergent role in both cell survival and cell death during ischemia/reperfusion (I/R) injury and associated inflammation. In this study, ROS generation by activated macrophages evoked an intracellular Ca2+ ([Ca2+]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc662d80293ba2df3732c780ca599a7
https://doi.org/10.1083/jcb.200505022
https://doi.org/10.1083/jcb.200505022
Autor:
Larry E. Wagner, David I. Yule, Edward P. Morris, Zachary T. Schug, Bradley Bailey, Paula C. A. da Fonseca, Xianchao Zhang, Suresh K. Joseph, Cunnigaiper D. Bhanumathy
Publikováno v:
The Journal of biological chemistry. 283(5)
Specific residues in the putative pore helix, selectivity filter, and S6 transmembrane helix of the inositol 1,4,5-trisphosphate receptor were mutated in order to examine their effects on channel function. Mutation of 5 of 8 highly conserved residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a5f3fe0398ea491fab5c41347f1e76
https://pubmed.ncbi.nlm.nih.gov/18025085
https://pubmed.ncbi.nlm.nih.gov/18025085
Publikováno v:
The Journal of biological chemistry. 282(45)
The role of inositol 1,4,5-trisphosphate receptors (IP(3)R) in caspase-3 activation and cell death was investigated in DT40 chicken B-lymphocytes stably expressing various IP(3)R constructs. Both full-length type-I IP(3)R and a truncated construct co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d533ab951384c820ff12af669d1a2d
https://pubmed.ncbi.nlm.nih.gov/17875645
https://pubmed.ncbi.nlm.nih.gov/17875645
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfa755346c3e7b983fd2927ecd927cda
https://doi.org/10.1096/fasebj.20.4.a118
https://doi.org/10.1096/fasebj.20.4.a118
Publikováno v:
The Journal of biological chemistry. 281(6)
A consensus RXRXX(S/T) substrate motif for Akt kinase is conserved in the C-terminal tail of all three inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) isoforms. We have shown that IP3R can be phosphorylated by Akt kinase in vitro and in vivo. Endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148d6c7ffdb40af92f4a1ecaaa157688
https://pubmed.ncbi.nlm.nih.gov/16332683
https://pubmed.ncbi.nlm.nih.gov/16332683