Toll-like receptor-targeted anti-tumor therapies: Advances and challenges

Autor: Yang Yang, Hongyi Li, Christina Fotopoulou, Paula Cunnea, Xia Zhao

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to stimulate innate immune reactions against microbial infection. TLRs also play essential roles in bridging the innate and adaptive immune system, playing multiple r

Externí odkaz: https://doaj.org/article/4aa5fd08ee004d61bf94a8ac326c8744

A mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic- and molecular-phenotypes of epithelial ovarian cancer

Autor: Haonan Lu, Mubarik Arshad, Andrew Thornton, Giacomo Avesani, Paula Cunnea, Ed Curry, Fahdi Kanavati, Jack Liang, Katherine Nixon, Sophie T. Williams, Mona Ali Hassan, David D. L. Bowtell, Hani Gabra, Christina Fotopoulou, Andrea Rockall, Eric O. Aboagye

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Radiomics—the quantification of features within tumor images—has shown prognostic potential in cancer. Here, the authors use a machine learning approach to develop a radiomic-based small set of descriptors to predict ovarian cancer patient surviv

Externí odkaz: https://doaj.org/article/7fff94167bb54d9d9ccc2351fa73055a

Procedures for cryogenic X-ray ptychographic imaging of biological samples

Autor: M. Yusuf, F. Zhang, B. Chen, A. Bhartiya, K. Cunnea, U. Wagner, F. Cacho-Nerin, J. Schwenke, I. K. Robinson

Publikováno v: IUCrJ, Vol 4, Iss 2, Pp 147-151 (2017)

Biological sample-preparation procedures have been developed for imaging human chromosomes under cryogenic conditions. A new experimental setup, developed for imaging frozen samples using beamline I13 at Diamond Light Source, is described. This manus

Externí odkaz: https://doaj.org/article/d1a02a207e8a4f3b9f46f671d040a333

Inflammatory state of lymphatic vessels and miRNA profiles associated with relapse in ovarian cancer patients.

Autor: Sarah C Johnson, Sanjukta Chakraborty, Anastasios Drosou, Paula Cunnea, Dimitrios Tzovaras, Katherine Nixon, David C Zawieja, Mariappan Muthuchamy, Christina Fotopoulou, James E Moore

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0230092 (2020)

Lymphogenic spread is associated with poor prognosis in epithelial ovarian cancer (EOC), yet little is known regarding roles of non-peri-tumoural lymphatic vessels (LVs) outside the tumour microenvironment that may impact relapse. The aim of this fea

Externí odkaz: https://doaj.org/article/35eded80e8dc4494b0e09d3273e722f3

Validation analysis of the novel imaging-based prognostic radiomic signature in patients undergoing primary surgery for advanced high-grade serous ovarian cancer (HGSOC).

Autor: Fotopoulou C; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK. c.fotopoulou@imperial.ac.uk., Rockall A; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK.; Department of Radiology, Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK., Lu H; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK., Lee P; Department of Radiology, Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Avesani G; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK.; Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK.; Department of Imaging, Oncological Radiotherapy, and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Russo L; Department of Imaging, Oncological Radiotherapy, and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Petta F; Department of Imaging, Oncological Radiotherapy, and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Ataseven B; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Henricistr.92, 45136, Essen, Germany.; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, München, Germany., Waltering KU; Department of Radiology, Kliniken Essen-Mitte, Henricistr.92, 45136, Essen, Germany., Koch JA; Department of Radiology, Kliniken Essen-Mitte, Henricistr.92, 45136, Essen, Germany., Crum WR; Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK.; Institute of Translational Medicine and Therapeutics (ITMAT), Imperial College, London, UK., Cunnea P; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK., Heitz F; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Henricistr.92, 45136, Essen, Germany.; Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Harter P; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Henricistr.92, 45136, Essen, Germany., Aboagye EO; Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK., du Bois A; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Henricistr.92, 45136, Essen, Germany., Prader S; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Henricistr.92, 45136, Essen, Germany.; Department of Obstetrics and Gynecology, Brixen General Hospital, Brixen, Italy.; Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria.

Publikováno v: British journal of cancer [Br J Cancer] 2022 Apr; Vol. 126 (7), pp. 1047-1054. Date of Electronic Publication: 2021 Dec 18.