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pro vyhledávání: '"Cunliffe, V.T."'
The roles of androgens in male reproductive development and function in zebrafish are poorly understood. To investigate this topic we employed CRISPR/Cas9 to generate cyp11c1 (11β-hydroxylase) mutant zebrafish lines. Our study confirms recently publ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f6f1512052a86562303e82a978d93738
https://eprints.whiterose.ac.uk/165743/1/OakesETAL2020cyp11c1preprint.pdf
https://eprints.whiterose.ac.uk/165743/1/OakesETAL2020cyp11c1preprint.pdf
Cytochrome P450 side-chain cleavage enzyme, encoded by the CYP11A1 gene, catalyzes the first and rate-limiting step of steroid hormone biosynthesis. Previous morpholino knockdown studies in zebrafish suggested cyp11a2 is a functional equivalent of hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::89bdd480fcc449c370b7acb687b7fce8
Autor:
Oakes, J.A., Li, N., Wistow, B.R.C., Griffin, A., Barnard, L., Storbeck, K.-H., Cunliffe, V.T., Krone, N.P.
The roles of steroids in zebrafish sex differentiation, gonadal development and function of the adult gonad are poorly understood. Herein, we have employed a ferredoxin 1b (fdx1b) mutant zebrafish to explore such processes. Fdx1b is an essential elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::fac36e378c94257bbf24bc3e162ac692
https://eprints.whiterose.ac.uk/148928/1/en.2019-00068_R2.pdf
https://eprints.whiterose.ac.uk/148928/1/en.2019-00068_R2.pdf
Autor:
Wong, S.Q., Jones, A., Dodd, S., Grimes, D., Barclay, J.W., Marson, A.G., Cunliffe, V.T., Burgoyne, R.D., Sills, G.J., Morgan, A.
Publikováno v:
Journal of Neuroscience Methods
BACKGROUND: Epilepsy affects around 1% of people, but existing antiepileptic drugs (AEDs) only offer symptomatic relief and are ineffective in approximately 30% of patients. Hence, new AEDs are sorely needed. However, a major bottleneck is the low-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5776fb32def1e44a4f0a01444d0d84bc
https://eprints.whiterose.ac.uk/137439/1/1-s2.0-S016502701830270X-main.pdf
https://eprints.whiterose.ac.uk/137439/1/1-s2.0-S016502701830270X-main.pdf
Akademický článek
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Akademický článek
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Autor:
Eachus, H., Cunliffe, V.T.
We provide an overview of recent progress in elucidating the epigenetic mechanisms through which the impacts of psychosocial stressors become biologically embedded, thereby influencing physiology and modulating disease susceptibility. We focus on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f7734d6e98df656abf4abe49ef52fbe9
https://eprints.whiterose.ac.uk/126031/1/EachusCunliffeSUBMITTED.pdf
https://eprints.whiterose.ac.uk/126031/1/EachusCunliffeSUBMITTED.pdf
Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm
Laminin-111 (α1β1γ1) is a member of the Laminin family of extra-cellular matrix proteins that comprises 16 members, components of basement membranes. Laminin-111, one of the first Laminin proteins synthesised during embryogenesis, is required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5fb0ec40093ae4ea40d76fdf5b32c09c
https://eprints.whiterose.ac.uk/108634/1/1-s2.0-S0945053X16302244-main.pdf
https://eprints.whiterose.ac.uk/108634/1/1-s2.0-S0945053X16302244-main.pdf
Autor:
Eachus, H., Zaucker, A., Oakes, J.A., Griffin, A., Weger, M., Güran, T., Taylor, A., Harris, A., Greenfield, A., Quanson, J.L., Storbeck, K.-H., Cunliffe, V.T., Müller, F., Krone, N.
Congenital adrenal hyperplasia is a group of common inherited disorders leading to glucocorticoid deficiency. Most cases are caused by 21-hydroxylase deficiency (21OHD). The systemic consequences of imbalanced steroid hormone biosynthesis due to seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6ebfaca5f681b1e6cadb713bca3fefd1
https://eprints.whiterose.ac.uk/123026/1/en.2017-00549.pdf
https://eprints.whiterose.ac.uk/123026/1/en.2017-00549.pdf
Psychiatric disorders arise due to an interplay of genetic and environmental factors, including stress. Studies in rodents have\ud shown that mutants for Disrupted-In-Schizophrenia-1 (DISC1), a well-accepted genetic risk factor for mental illness, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::fbce99959d5203785efeaf0810fa2a3d
https://eprints.whiterose.ac.uk/112790/8/ddx076.pdf
https://eprints.whiterose.ac.uk/112790/8/ddx076.pdf