Výsledky vyhledávání - "Cunchang Liu"

Hedgehog Signaling Controls Bone Homeostasis by Regulating Osteogenic/Adipogenic Fate of Skeletal Stem/Progenitor Cells in Mice

Autor: Liwei Zhang, Xuejie Fu, Li Ni, Cunchang Liu, Yixin Zheng, Hongji You, Meng Li, Chunmei Xiu, Lei Zhang, Tingting Gong, Na Luo, Zunyi Zhang, Guangxu He, Shijun Hu, Huilin Yang, Di Chen, Jianquan Chen

Publikováno v: Journal of Bone and Mineral Research. 37:559-576

Skeletal stem/progenitor cells (SSPCs) can differentiate into osteogenic or adipogenic lineage. The mechanism governing lineage allocation of SSPCs is still not completely understood. Hedgehog (Hh) signaling plays an essential role in specifying oste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fc30b473253ff7a4b1de853ef8609d
https://doi.org/10.1002/jbmr.4485

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Author response for 'Hedgehog signaling controls bone homeostasis by regulating osteogenic/adipogenic fate of skeletal stem/progenitor cells in mice'

Autor: null Liwei Zhang, null Xuejie Fu, null Li Ni, null Cunchang Liu, null Yixin Zheng, null Hongji You, null Meng Li, null Chunmei Xiu, null Lei Zhang, null Tingting Gong, null Na Luo, null Zunyi Zhang, null Guangxu He, null Shijun Hu, null Huilin Yang, null Di Chen, null Jianquan Chen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eff3d6e3eb350f9dc1b874cd3dba5d3b
https://doi.org/10.1002/jbmr.4485/v2/response1

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Characterization of Cre recombinase mouse lines enabling cell type‐specific targeting of postnatal intervertebral discs

Autor: Cunchang Liu, Zunyi Zhang, Saijilafu, Qingbai Liu, Tingting Gong, Jianquan Chen, Hongting Jin, Yixin Zheng, Xuejie Fu, Shengqi Guan, Chunmei Xiu, Di Chen

Publikováno v: J Cell Physiol

Cre/loxP technology is an important tool for studying cell type-specific gene functions. Cre recombinase mouse lines, including Agc1-CreER(T2), Col2a1-Cre; Col2a1-CreER(T2), Shh-Cre, Shh-CreER(T2), and Osx-Cre, have been proven to be valuable tools t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dae4a5b7c21a2670896010ec4c1458
https://doi.org/10.1002/jcp.28166

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Cell type‐specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration

Autor: Jun Lin, Li Ni, Zhaoyang Liu, Bin Li, Jianquan Chen, Anthony J. Mirando, Cunchang Liu, Di Chen, Yixin Zheng, Matthew J. Hilton, Saijilafu

Publikováno v: Journal of Cellular Physiology. 233:5431-5440

Intervertebral disc (IVD) degeneration is the major cause of back pain. Notch signaling is activated in annulus fibrosus (AF) and nucleus pulposus (NP) tissues of degenerated IVDs, and induced by IL1-β and TNF-α in NP cells. However, the role of No

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe6dfca56d97495d76d95f47cefcc9a
https://doi.org/10.1002/jcp.26385

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Osteocyte-intrinsic mTORC1 signaling restrains trabecular bone accrual in mice

Autor: Huilin Yang, Jianquan Chen, Cunchang Liu, Qingbai Liu, Yanjun Yang

Publikováno v: Journal of cellular biochemistry. 119(11)

Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling plays important physiological roles in bone homeostasis by regulating multiple steps of osteoblast differentiation as well as its activity. However, its potential role in osteocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bb544619f7f5343f6a4271aafae855
https://pubmed.ncbi.nlm.nih.gov/30160781

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