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Akademický článek

Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins

Autor: Cuncai Guo, Dorothee Reuss, Jonathon D. Coey, Swathi Sukumar, Benjamin Lang, John McLauchlan, Steeve Boulant, Megan L. Stanifer, Connor G. G. Bamford

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Interferon lambdas (IFNλ) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver, and gastrointestinal tract. Humans have four IFNλs (1–4), where IFNλ1–3 show ~80%�

Externí odkaz: https://doaj.org/article/dfa5ef4c8962486d9e2125865902a27f

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Akademický článek

Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces

Autor: Megan L. Stanifer, Cuncai Guo, Patricio Doldan, Steeve Boulant

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs).

Externí odkaz: https://doaj.org/article/1dc5c50f8ad043c2a862ce8226b4fd8a

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Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

Autor: A. Rouf Banday, Megan L. Stanifer, Oscar Florez-Vargas, Olusegun O. Onabajo, Brenen W. Papenberg, Muhammad A. Zahoor, Lisa Mirabello, Timothy J. Ring, Chia-Han Lee, Paul S. Albert, Evangelos Andreakos, Evgeny Arons, Greg Barsh, Leslie G. Biesecker, David L. Boyle, Mark S. Brahier, Andrea Burnett-Hartman, Mary Carrington, Euijin Chang, Pyoeng Gyun Choe, Rex L. Chisholm, Leandro M. Colli, Clifton L. Dalgard, Carolynn M. Dude, Jeff Edberg, Nathan Erdmann, Heather S. Feigelson, Benedito A. Fonseca, Gary S. Firestein, Adam J. Gehring, Cuncai Guo, Michelle Ho, Steven Holland, Amy A. Hutchinson, Hogune Im, Les’Shon Irby, Michael G. Ison, Naima T. Joseph, Hong Bin Kim, Robert J. Kreitman, Bruce R. Korf, Steven M. Lipkin, Siham M. Mahgoub, Iman Mohammed, Guilherme L. Paschoalini, Jennifer A. Pacheco, Michael J. Peluso, Daniel J. Rader, David T. Redden, Marylyn D. Ritchie, Brooke Rosenblum, M. Elizabeth Ross, Hanaisa P. Sant Anna, Sharon A. Savage, Sudha Sharma, Eleni Siouti, Alicia K. Smith, Vasiliki Triantafyllia, Joselin M. Vargas, Jose D. Vargas, Anurag Verma, Vibha Vij, Duane R. Wesemann, Meredith Yeager, Xu Yu, Yu Zhang, Steeve Boulant, Stephen J. Chanock, Jordan J. Feld, Ludmila Prokunina-Olsson

Publikováno v: Nature Genetics. 54:1103-1116

The chr12q24.13 locus encoding OAS1–OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this locus in relation to COVID-19 severity. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37dd9b81fcf718f9727fc32dc0c8e6d8
https://doi.org/10.1038/s41588-022-01113-z

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The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms

Autor: Liping He, Steeve Boulant, Megan Stanifer, Cuncai Guo, Anna Nießen, Mingyi Chen, Klaus Felix, Frank Bergmann, Oliver Strobel, Simon Schimmack

Publikováno v: Cancer Science. 113:1575-1586

MEN1, which encodes menin protein, is the most frequently mutated gene in pancreatic neuroendocrine neoplasms (pNEN). Pleiotrophin (PTN) has been reported as a downstream factor of menin that promotes metastasis in different tumor entities. In this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faedf2fff99fab89584fe8c325ea03b
https://doi.org/10.1111/cas.15301

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Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial Cells

Autor: Camila Metz-Zumaran, Carmon Kee, Patricio Doldan, Cuncai Guo, Megan L. Stanifer, Steeve Boulant

Publikováno v: Journal of Virology. 96

The coronavirus SARS-CoV-2 caused the COVID-19 global pandemic leading to 5.3 million deaths worldwide as of December 2021. The human intestine was found to be a major viral target which could have a strong impact on virus spread and pathogenesis sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24906baa3a58e3c46e32e114d228a73a
https://doi.org/10.1128/jvi.01705-21

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Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins

Autor: Connor G. G. Bamford, Cuncai Guo, Jonathon D. Coey, John McLauchlan, Benjamin Lang, Steeve Boulant, Dorothee Reuss, Swathi Sukumar, Megan L. Stanifer

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Guo, C, Reuss, D, Coey, J D, Sukumar, S, Lang, B, McLauchlan, J, Boulant, S, Stanifer, M L & Bamford, C G G 2021, ' Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins ', Frontiers in immunology, vol. 12, 772588 . https://doi.org/10.3389/fimmu.2021.772588

Interferon lambdas (IFN{lambda}) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver and gastrointestinal tract. Humans have four IFN{lambda}s (1-4) where IFN{lambda}1-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07112a8243e7ec76451535fe039fd7a5
http://europepmc.org/articles/PMC8636442

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Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells

Autor: Steeve Boulant, Camila Metz-Zumaran, Cuncai Guo, Carmon Kee, Patricio Doldan, Megan L. Stanifer

The coronavirus SARS-CoV-2 caused the COVID-19 global pandemic leading to 3.5 million deaths worldwide as of June 2021. The human intestine was found to be a major viral target which could have a strong impact on virus spread and pathogenesis since i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::705eb968332aa509dc9f841d34dba6ee
https://doi.org/10.1101/2021.06.14.448464

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Type-Specific Crosstalk Modulates Interferon Signaling in Intestinal Epithelial Cells

Autor: Kalliopi Pervolaraki, Megan L. Stanifer, Steeve Boulant, Cuncai Guo, Dorothee Albrecht

Publikováno v: Journal of Interferon & Cytokine Research. 39:650-660

Intestinal epithelial cells (IECs) are the primary target of enteric viruses. Their infection by viruses leads to the upregulation of both type I and type III interferons (IFNs). These IFNs then act in an autocrine and paracrine manner to protect IEC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7660d9574b39f22855b7a69eb19fca
https://doi.org/10.1089/jir.2019.0040

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Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces

Autor: Patricio Doldan, Steeve Boulant, Megan L. Stanifer, Cuncai Guo

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa71faa23b17e74249835c7834a5830a
https://pubmed.ncbi.nlm.nih.gov/33362795

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