Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Cun-Xin Wang"'
Publikováno v:
Molecules, Vol 15, Iss 3, Pp 1903-1917 (2010)
Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide deriv
Externí odkaz:
https://doaj.org/article/c7765507507942be927e67672cd9c8ab
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 85:741-752
Protein-RNA docking is still an open question. One of the main challenges is to develop an effective scoring function that can discriminate near-native structures from the incorrect ones. To solve the problem, we have constructed a knowledge-based re
Publikováno v:
RSC Advances. 6:27594-27606
At present, the approved HIV integrase (IN) inhibitors are all diketo-acids (DKAs). To have a better understanding of DKA inhibitors, comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), docking, a
Autor:
Yong Xiao Yang, Lu Jin, Xiao Lu Xie, Chun Hua Li, Cun Xin Wang, Ji Guo Su, Xiao Yi Zhang, Jianjun Tan
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 83:1643-1653
The transporter MsbA is a kind of multidrug resistance ATP-binding cassette transporter that can transport lipid A, lipopolysaccharides, and some amphipathic drugs from the cytoplasmic to the periplasmic side of the inner membrane. In this work, we e
Publikováno v:
Biopolymers. 101:758-768
The maltose transporter from Escherichia coli is one of the ATP-binding cassette (ABC) transporters that utilize the energy from ATP hydrolysis to translocate substrates across cellular membranes. Until 2011, three crystal structures have been determ
Publikováno v:
Current Pharmaceutical Design. 19:1810-1817
HIV-1 membrane fusion as a part of the process of viral entry in the target cells is facilitated by gp41 and gp120, which are encoded by Env gene of HIV-1. Based on the structure and the mechanism researches, new treatment options targeting HIV-1 ent
Publikováno v:
Proteins. 85(4)
Protein-RNA docking is still an open question. One of the main challenges is to develop an effective scoring function that can discriminate near-native structures from the incorrect ones. To solve the problem, we have constructed a knowledge-based re
Publikováno v:
SAR and QSAR in Environmental Research. 23:683-703
In the process of HIV-1 virus replication, integrase plays a quite important role. Integrase inhibitors of quinoline ring derivatives were analysed by the Comparative Molecular Field Analysis (CoMFA), Comparative Molecular Similarity Induces Analysis
Autor:
Bin Liu, Lei Fu Yang, Ren Kong, Jianjun Tan, Bin Zhang, Zhi Yao Kui, Liming Hu, Xiaojing Cong, Cun Xin Wang
Publikováno v:
Medicinal Chemistry. 7:309-316
This discovered and optimized several novel HIV-1 fusion inhibitors and further evaluated the inhibitory activities of these compounds in vitro. Here, we have reported the computer-aided design, synthesis, and biological evaluation of a series of sma
Publikováno v:
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. 37:904-915