Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Cun Yu Wang"'
Autor:
Wei Liu, Hongchao Cao, Jing Wang, Areeg Elmusrati, Bing Han, Wei Chen, Ping Zhou, Xiyao Li, Stephen Keysar, Antonio Jimeno, Cun-Yu Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Histone lysine methyltransferase 2D (KMT2D) is the most frequently mutated epigenetic modifier in head and neck squamous cell carcinoma (HNSCC). However, the role of KMT2D in HNSCC tumorigenesis and whether its mutations confer any therapeut
Externí odkaz:
https://doaj.org/article/2acb42a0ff5e40cf83170523fb94604f
Publikováno v:
International Journal of Oral Science, Vol 14, Iss 1, Pp 1-11 (2022)
Abstract Aging of craniofacial skeleton significantly impairs the repair and regeneration of trauma-induced bony defects, and complicates dental treatment outcomes. Age-related alveolar bone loss could be attributed to decreased progenitor pool throu
Externí odkaz:
https://doaj.org/article/a4b7b5cabc5f4e49ab1fb6bdbbe878d6
Autor:
Zhenqing Liu, Hye-Lim Lee, Jin Sook Suh, Peng Deng, Chang-Ryul Lee, Olga Bezouglaia, Mojan Mirnia, Vivian Chen, Michael Zhou, Zhong-Kai Cui, Reuben H. Kim, Min Lee, Tara Aghaloo, Christine Hong, Cun-Yu Wang
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract Osteoporosis is a highly prevalent public health burden associated with an increased risk of bone fracture, particularly in aging women. Estrogen, an important medicinal component for the preventative and therapeutic treatment of postmenopau
Externí odkaz:
https://doaj.org/article/21e84eda55844185afcecd4d6c46b2c7
Autor:
Xinmin Li, Cun-Yu Wang
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-6 (2021)
Abstract RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomic
Externí odkaz:
https://doaj.org/article/83b2ddf152304608adbe69c6ad05caf9
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery, conventional cytotoxic chemotherapy, and irradia
Externí odkaz:
https://doaj.org/article/759526812374470f8ecefa7daa4b6844
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Little is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, ther
Externí odkaz:
https://doaj.org/article/65a0996e08e9453696eacebfb2075399
Autor:
Yu Wang, Shanshan Jin, Dan Luo, Danqing He, Chunyan Shi, Lisha Zhu, Bo Guan, Zixin Li, Ting Zhang, Yanheng Zhou, Cun-Yu Wang, Yan Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The regeneration of functional tendons remains a clinical challenge. Here the authors develop a biomimetic scaffold loaded with recombinant periostin and demonstrate its functionality in promoting tendon stem/progenitor cell recruitment and tenogenic
Externí odkaz:
https://doaj.org/article/bd4583826f0e4afa87e882618523d270
Autor:
Thanuja D. K. Herath, Richard P. Darveau, Chaminda J. Seneviratne, Cun-Yu Wang, Yu Wang, Lijian Jin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a0ebfc2f27434c29a1c495dcee643c5e
Publikováno v:
Advanced Science, Vol 8, Iss 13, Pp n/a-n/a (2021)
Abstract Cancer stemness and immune evasion are closely associated, and play critical roles in tumor development and resistance to immunotherapy. However, little is known about the underlying molecular mechanisms that coordinate this association. Her
Externí odkaz:
https://doaj.org/article/eb24b3deaf9c451fa336fb99d3762af7
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100484- (2021)
Summary: BMI1-expressing cancer stem cells (CSCs) play a key role in the development, progression, therapy resistance, recurrence, and metastasis of head and neck squamous cell carcinoma (HNSCC). Here, we present a chemically-induced HNSCC mouse mode
Externí odkaz:
https://doaj.org/article/3aa28b201bd54499a47b3f0a000b6582