Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Cun Tan"'
Autor:
Yu-xiang Wang, Xu Zhang, Qing-yang Ma, Lan-dian Hu, Xi Zhang, Yi Wang, Lan Xu, Chun-hao Yang, Cun Tan, Xiang-yin Kong, Jian Ding, Ling-hua Meng
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Phosphoinositide-3 kinase alpha-specific inhibitors (PI3Kαi) displayed promising potential for the treatment of esophageal squamous cell carcinoma (ESCC) with frequent activation in PI3K signaling. However, acquired resistance is likely to
Externí odkaz:
https://doaj.org/article/e86fa4e218ec48b6b0441df9763b31ff
Autor:
Yuxiang Wang, Xian Li, Xueling Liu, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding, Linghua Meng
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 1, Pp 66-83 (2019)
Objective Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer (NSCLC). However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI3K signaling plays an important
Externí odkaz:
https://doaj.org/article/e333f50569794264bdd828f1bc042697
Autor:
Yuxiang Wang, Xian Li, Xueling Liu, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding, Linghua Meng
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 4, Pp 836-836 (2019)
Externí odkaz:
https://doaj.org/article/11c34383a10340be9a12111d16cbb908
Autor:
Chunhao Yang, Lan Xu, Landian Hu, Xiangyin Kong, Qingyang Ma, Yi Wang, Yu-xiang Wang, Xu Zhang, Linghua Meng, Jian Ding, Xi Zhang, Cun Tan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Phosphoinositide-3 kinase alpha-specific inhibitors (PI3Kαi) displayed promising potential for the treatment of esophageal squamous cell carcinoma (ESCC) with frequent activation in PI3K signaling. However, acquired resistance is likely to develop a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f03fcaef4a17aeab690b761afa98c1e
https://doi.org/10.1038/s41419-020-03370-4
https://doi.org/10.1038/s41419-020-03370-4
Autor:
Yinglei Gao, Cun Tan, Chunhao Yang, Yiming Sun, Xue-ling Liu, Jian Ding, Yu-xiang Wang, Yu-chao Zhang, Yi-chao Xu, Qingyang Ma, Yanhong Chen, Bo-bo Wang, Yi Chen, Yi Wang, Linghua Meng, Lan-ding Hu
Publikováno v:
Cancer Letters. 433:273-282
PI3Ks are frequently hyper-activated in breast cancer and targeting PI3Kα has exhibited promising but variable response in preclinical and clinical settings. CYH33 is a novel PI3Kα-selective inhibitor in phase I clinical trial. We investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e4ec7862271e68ba5a2d7a85970498
https://doi.org/10.1016/j.canlet.2018.07.011
https://doi.org/10.1016/j.canlet.2018.07.011
Autor:
Lie-Feng Ma1, Cun-Tan Miao1, Hao-Ying Qian1, Peng-Fei Wang1, Fa-Song Wang2, Zha-Jun Zhan1, Wei-Guang Shan1 zjnpr@zjut.edu.cn
Publikováno v:
Journal of Chemical Research. Apr2017, Vol. 41 Issue 4, p195-198. 4p.
Autor:
Cun-Tan Miao, Zha-Jun Zhan, Fa-Song Wang, Lie-Feng Ma, Hao-Ying Qian, Peng-Fei Wang, Wei-Guang Shan
Publikováno v:
Journal of Chemical Research. 41:195-198
Cynotophyllosides M–O, three new polyhydroxypregnane glycosides, were obtained from the roots of Cynanchum otophyllum, together with four known compounds, deacetylmetaplexignin, sarcostion, cynotophylloside J and kidjoranin 3-O-α-diginopyranosyl-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3771ccf941bb797df36222b74765006
https://doi.org/10.3184/174751917x14894997017414
https://doi.org/10.3184/174751917x14894997017414
Autor:
Chuan-Huizi Chen, Xiao-Yan Chen, Jin-Xue He, Yu-Ting Wang, Chunhao Yang, Meng Wang, Yi Su, Ze-Hong Miao, Yi Chen, Shanshan Song, Xinying Yang, Linjiang Tong, Cun Tan, Jian Ding, Zhi-Wei Gao, Yiming Sun, Qian He, Bing Xiong, Xiao-hua Li, Huan Xiajuan, Xiu-Lian Lu, Xue-mei Liao, Yanyan Shen, Ying-Qing Wang
Publikováno v:
Oncotarget
// Jin-Xue He 1, * , Meng Wang 2, * , Xia-Juan Huan 1 , Chuan-Huizi Chen 1 , Shan-Shan Song 1 , Ying-Qing Wang 1 , Xue-Mei Liao 1 , Cun Tan 2 , Qian He 2 , Lin-Jiang Tong 1 , Yu-Ting Wang 1 , Xiao-Hua Li 1 , Yi Su 1 , Yan-Yan Shen 1 , Yi-Ming Sun 1 ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2d7453f42fa2388a4f7db05dcb5204
http://europepmc.org/articles/PMC5354820
http://europepmc.org/articles/PMC5354820
Autor:
Linghua Meng, Xi Zhang, Yi Wang, Jian Ding, Chunhao Yang, Cun Tan, Yu-xiang Wang, Bo-bo Wang, Qiao-Jun He, Xue-ling Liu
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 4, Iss 1, Pp 1-3 (2019)
Signal Transduction and Targeted Therapy, Vol 4, Iss 1, Pp 1-3 (2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1353a2d75f4222f3acb7536f8c2fbbce
https://doi.org/10.1038/s41392-019-0085-2
https://doi.org/10.1038/s41392-019-0085-2
Autor:
Zhaobing Gao, Jian Ding, Cun Tan, Zhi-Wei Gao, Hao-Yue Xiang, Chunhao Yang, Yanhong Chen, Yi Wang, Yi Chen, Linghua Meng, Yi Su, Xi Zhang, Xiang Wang, Xiaoyan Chen, Bing Xiong
Publikováno v:
European Journal of Medicinal Chemistry. 209:112913
In various human cancers, PI3Ks pathway is ubiquitously dysregulated and thus become a promising anti-cancer target. To discover new potent and selective PI3K inhibitors as potential anticancer drugs, new pyrrolo[2,1-f][1,2,4]triazines were designed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7eb13230ba2b34cbb2c3b78295cb8d
https://doi.org/10.1016/j.ejmech.2020.112913
https://doi.org/10.1016/j.ejmech.2020.112913