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Designer proteins that competitively inhibit Gαq by targeting its effector site.

Autor: Hussain, Mahmud^1,2, Cummins, Matthew C.³, Endo-Streeter, Stuart³, Sondek, John^1,3,4 sondek@med.unc.edu, Kuhlman, Brian^1,4 bkuhlman@email.unc.edu

Publikováno v: Journal of Biological Chemistry. Dec2021, Vol. 297 Issue 6, p1-14. 14p.

De novo design of stable proteins that efficaciously inhibit oncogenic G proteins.

Autor: Cummins MC; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Tripathy A; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Sondek J; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Kuhlman B; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 28. Date of Electronic Publication: 2023 Mar 28.