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Evaluation of resazurin phenoxazine dye as a highly sensitive cell viability potency assay for natural killer cell-derived extracellular vesicle-based cancer biotherapeutics.

Autor: St-Denis-Bissonnette F; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada.; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Qiu S; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Cummings SE; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Kirkby M; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada.; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Haile Y; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada.; Department of Neuroscience Carleton University Ottawa Canada., Wassmer S; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Muradia G; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Mehic J; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Stalker A; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada., Shrestha A; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada., Ardolino M; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada.; Centre for Infection, Immunity and Inflammation University of Ottawa Ottawa Canada.; Cancer Therapeutics Program Ottawa Hospital Research Institute Ottawa Canada., Lee SH; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada.; Centre for Infection, Immunity and Inflammation University of Ottawa Ottawa Canada., Burger D; Kidney Research Centre Ottawa Hospital Research Institute Ottawa Canada.; Department of Cellular and Molecular Medicine University of Ottawa Ottawa Canada., Wang L; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada.; Centre for Infection, Immunity and Inflammation University of Ottawa Ottawa Canada.; Regenerative Medicine Program Ottawa Hospital Research Institute Ottawa Canada., Lavoie JR; Biologic and Radiopharmaceutical Drugs Directorate Health Canada Ottawa Canada.; Department of Biochemistry, Microbiology and Immunology University of Ottawa Ottawa Canada.

Publikováno v: Journal of extracellular biology [J Extracell Biol] 2024 Jul 17; Vol. 3 (7), pp. e166. Date of Electronic Publication: 2024 Jul 17 (Print Publication: 2024).

Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination.

Autor: Kornfeld SF; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Cummings SE; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Yaworski R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., De Repentigny Y; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Gagnon S; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Zandee S; Neuroimmunology Unit and Multiple Sclerosis Clinic, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Fathi S; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Prat A; Neuroimmunology Unit and Multiple Sclerosis Clinic, The Research Center of the Centre Hospitalier de l'Université de Montréal (CRCHUM), Department of Neuroscience, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Kothary R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. rkothary@ohri.ca.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. rkothary@ohri.ca.; Department of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. rkothary@ohri.ca.; Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. rkothary@ohri.ca.

Publikováno v: Communications biology [Commun Biol] 2024 Jul 04; Vol. 7 (1), pp. 813. Date of Electronic Publication: 2024 Jul 04.

A clinically relevant large-scale biomanufacturing workflow to produce natural killer cells and natural killer cell-derived extracellular vesicles for cancer immunotherapy.

Autor: St-Denis-Bissonnette F; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Cummings SE; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Qiu S; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Stalker A; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Muradia G; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Mehic J; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Mediratta K; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada., Kaczmarek S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada., Burger D; Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada., Lee SH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada., Wang L; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Lavoie JR; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Publikováno v: Journal of extracellular vesicles [J Extracell Vesicles] 2023 Dec; Vol. 12 (12), pp. e12387.

Oligodendrocyte development and CNS myelination are unaffected in a mouse model of severe spinal muscular atrophy.

Autor: O'Meara RW; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada., Cummings SE; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada., De Repentigny Y; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada., McFall E; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada., Michalski JP; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada., Deguise MO; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada., Gibeault S; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada., Kothary R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.; University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada.; Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2017 Jan 15; Vol. 26 (2), pp. 282-292.