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Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate.

Autor: Punthasee P; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States., Laciak AR; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States., Cummings AH; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States., Ruddraraju KV; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States., Lewis SM; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States., Hillebrand R; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States., Singh H; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States., Tanner JJ; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States.; Department of Biochemistry, University of Missouri , 117 Schweitzer Hall, Columbia, Missouri 65211, United States., Gates KS; Department of Chemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States.; Department of Biochemistry, University of Missouri , 117 Schweitzer Hall, Columbia, Missouri 65211, United States.

Publikováno v: Biochemistry [Biochemistry] 2017 Apr 11; Vol. 56 (14), pp. 2051-2060. Date of Electronic Publication: 2017 Apr 03.

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Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine.

Autor: Sarkar U; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Hillebrand R; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Johnson KM; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Cummings AH; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Phung NL; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Rajapakse A; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Zhou H; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Willis JR; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Barnes CL; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Gates KS; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.; University of Missouri, Department of Biochemistry, 125 Chemistry Building, Columbia, MO 65211.

Publikováno v: Journal of heterocyclic chemistry [J Heterocycl Chem] 2017 Jan; Vol. 54 (1), pp. 155-160. Date of Electronic Publication: 2015 Nov 25.

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Akademický článek

Redox regulation of protein tyrosine phosphatases: structural and chemical aspects.

Autor: Tanner JJ; Department of Chemistry, University of Missouri, Columbia, 65211, USA. tannerjj@missouri.edu, Parsons ZD, Cummings AH, Zhou H, Gates KS

Publikováno v: Antioxidants & redox signaling [Antioxid Redox Signal] 2011 Jul 01; Vol. 15 (1), pp. 77-97. Date of Electronic Publication: 2011 Apr 13.

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Akademický článek

Protection of a single-cysteine redox switch from oxidative destruction: On the functional role of sulfenyl amide formation in the redox-regulated enzyme PTP1B.

Autor: Sivaramakrishnan S; Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65211, USA., Cummings AH, Gates KS

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 15; Vol. 20 (2), pp. 444-7. Date of Electronic Publication: 2009 Dec 04.

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