Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling.

Autor: d'Hennezel E; Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research Inc., Cambridge, Massachusetts, USA., Abubucker S; Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research Inc., Cambridge, Massachusetts, USA., Murphy LO; Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research Inc., Cambridge, Massachusetts, USA., Cullen TW; Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research Inc., Cambridge, Massachusetts, USA.

Publikováno v: MSystems [mSystems] 2017 Nov 14; Vol. 2 (6). Date of Electronic Publication: 2017 Nov 14 (Print Publication: 2017).

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Autor: Vatanen T; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Computer Science, Aalto University School of Science, 02150 Espoo, Finland., Kostic AD; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., d'Hennezel E; Novartis Institutes for Biomedical Research Inc., Cambridge, MA 02139, USA., Siljander H; Children's Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland; Research Programs Unit, Diabetes and Obesity Research Program, University of Helsinki, 00290 Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland., Franzosa EA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., Yassour M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kolde R; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Arthur TD; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hämäläinen AM; Department of Pediatrics, Jorvi Hospital, Helsinki University Hospital, 02740 Espoo, Finland., Peet A; Department of Pediatrics, University of Tartu and Tartu University Hospital, 51014 Tartu, Estonia., Tillmann V; Department of Pediatrics, University of Tartu and Tartu University Hospital, 51014 Tartu, Estonia., Uibo R; Department of Immunology, Institute of Biomedicine and Translational Medicine, Centre of Excellence for Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Mokurov S; Ministry of Health and Social Development, Karelian Republic of the Russian Federation, Lenin Street 6, 185035 Petrozavodsk, Russia., Dorshakova N; Petrozavodsk State University, Department of Family Medicine, Lenin Street 33, 185910 Petrozavodsk, Russia., Ilonen J; Immunogenetics Laboratory, University of Turku, 20520 Turku, Finland; Department of Clinical Microbiology, University of Eastern Finland, 70211 Kuopio, Finland., Virtanen SM; Department of Health, National Institute for Health and Welfare, 00271 Helsinki, Finland; School of Health Sciences, University of Tampere, 33014 Tampere, Finland; Science Centre, Pirkanmaa Hospital District and Research Center for Child Health, University Hospital, 33521 Tampere, Finland., Szabo SJ; Novartis Institutes for Biomedical Research Inc., Cambridge, MA 02139, USA., Porter JA; Novartis Institutes for Biomedical Research Inc., Cambridge, MA 02139, USA., Lähdesmäki H; Department of Computer Science, Aalto University School of Science, 02150 Espoo, Finland., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., Gevers D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Cullen TW; Novartis Institutes for Biomedical Research Inc., Cambridge, MA 02139, USA., Knip M; Children's Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland; Research Programs Unit, Diabetes and Obesity Research Program, University of Helsinki, 00290 Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland; Folkhälsan Research Center, 00290 Helsinki, Finland., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: xavier@molbio.mgh.harvard.edu.

Publikováno v: Cell [Cell] 2016 May 05; Vol. 165 (4), pp. 842-53. Date of Electronic Publication: 2016 Apr 28.

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria.

Autor: Tan Y; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115, USA., Zanoni I; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan 20126, Italy; Unit of Cell Signalling and Innate Immunity, Humanitas Clinical and Research Center, Rozzano 20089, Italy., Cullen TW; Department of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA., Goodman AL; Department of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA., Kagan JC; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: jonathan.kagan@childrens.harvard.edu.

Publikováno v: Immunity [Immunity] 2015 Nov 17; Vol. 43 (5), pp. 909-22. Date of Electronic Publication: 2015 Nov 03.

Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease.

Autor: Palm NW; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA., de Zoete MR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06510, USA., Cullen TW; Microbial Diversity Institute and Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA., Barry NA; Microbial Diversity Institute and Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA., Stefanowski J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA., Hao L; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA., Degnan PH; Microbial Diversity Institute and Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA., Hu J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Peter I; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zhang W; Departments of Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Ruggiero E; Departments of Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Cho JH; Departments of Medicine and Genetics, Yale University School of Medicine, New Haven, CT 06510, USA., Goodman AL; Microbial Diversity Institute and Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06510, USA. Electronic address: richard.flavell@yale.edu.

Publikováno v: Cell [Cell] 2014 Aug 28; Vol. 158 (5), pp. 1000-1010.

Characterization of unique modification of flagellar rod protein FlgG by Campylobacter jejuni lipid A phosphoethanolamine transferase, linking bacterial locomotion and antimicrobial peptide resistance.

Autor: Cullen TW; Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas 78712, USA., Madsen JA, Ivanov PL, Brodbelt JS, Trent MS

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2012 Jan 27; Vol. 287 (5), pp. 3326-36. Date of Electronic Publication: 2011 Dec 09.