Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cullen B, Young"'
Autor:
Shanshan Song, Lauren Yu, Md Nabiul Hasan, Satya S. Paruchuri, Steven J. Mullett, Mara L. G. Sullivan, Victoria M. Fiesler, Cullen B. Young, Donna B. Stolz, Stacy G. Wendell, Dandan Sun
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Song et al. use transgenic mice lacking the Na/H exchanger specifically in microglia to show that microglial oxidative phosphorylation plays a key role in post-stroke brain tissue repair and cognitive recovery. Their data is suggestive of a microglia
Externí odkaz:
https://doaj.org/article/e142eac368b54c4dbc767ae2fa4d5e53
Autor:
Qian Liu, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Shanshan Song, Gulnaz Begum, Cullen B. Young, Lesley M. Foley, Fenghua Chen, T. Kevin Hitchens, Guodong Cao, Ansuman Chattopadhyay, Li He, Dandan Sun
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-21 (2021)
Abstract Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation of Na+/H+ exchanger-1
Externí odkaz:
https://doaj.org/article/0b7b9c35d6e04796b892cecb0d5468ea
Autor:
Polakit Teekakirikul, Wenjuan Zhu, George C. Gabriel, Cullen B. Young, Kylia Williams, Lisa J. Martin, Jennifer C. Hill, Tara Richards, Marie Billaud, Julie A. Phillippi, Jianbin Wang, Yijen Wu, Tuantuan Tan, William Devine, Jiuann-huey Lin, Abha S. Bais, Jonathan Klonowski, Anne Moreau de Bellaing, Ankur Saini, Michael X. Wang, Leonid Emerel, Nathan Salamacha, Samuel K. Wyman, Carrie Lee, Hung Sing Li, Anastasia Miron, Jingyu Zhang, Jianhua Xing, Dennis M. McNamara, Erik Fung, Paul Kirshbom, William Mahle, Lazaros K. Kochilas, Yihua He, Vidu Garg, Peter White, Kim L. McBride, D. Woodrow Benson, Thomas G. Gleason, Seema Mital, Cecilia W. Lo
Publikováno v:
HGG Advances, Vol 2, Iss 3, Pp 100037- (2021)
Summary: Bicuspid aortic valve (BAV) with ∼1%–2% prevalence is the most common congenital heart defect (CHD). It frequently results in valve disease and aorta dilation and is a major cause of adult cardiac surgery. BAV is genetically linked to ra
Externí odkaz:
https://doaj.org/article/0b7019f7bd454037bec2471ea5feef8c
Autor:
Mohammad Iqbal H. Bhuiyan, Cullen B. Young, Israt Jahan, Md Nabiul Hasan, Sydney Fischer, Nur Farah Meor Azlan, Mingjun Liu, Ansuman Chattopadhyay, Huachen Huang, Kristopher T. Kahle, Jinwei Zhang, Samuel M. Poloyac, Bradley J. Molyneaux, Adam C. Straub, Xianming Deng, Delphine Gomez, Dandan Sun
Publikováno v:
Stroke
Background: Worsened stroke outcomes with hypertension comorbidity are insensitive to blood pressure-lowering therapies. In an experimental stroke model with comorbid hypertension, we investigated causal roles of ang II (angiotensin II)–mediated st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55550fbefbd3eb67eb23abdd0eb66361
https://doi.org/10.1161/strokeaha.121.038351
https://doi.org/10.1161/strokeaha.121.038351
Autor:
Dandan Sun, Ruijia Liu, Lesley M. Foley, Shanshan Song, Ansuman Chattopadhyay, T. Kevin Hitchens, fenghua chen, Li He, Gulnaz Begum, Cullen B. Young, Guodong Cao, Mohammad Iqbal H. Bhuiyan, Qian Liu
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-21 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation of Na+/H+ exchanger-1 (NHE1) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107647d71fde1e1dea6c318ee12c6825
https://doaj.org/article/0b7b9c35d6e04796b892cecb0d5468ea
https://doaj.org/article/0b7b9c35d6e04796b892cecb0d5468ea
Publikováno v:
Semin Cell Dev Biol
An essential role for cilia in the pathogenesis of congenital heart disease (CHD) has emerged from findings of a large-scale mouse forward genetic screen. High throughput screening with fetal ultrasound imaging followed by whole exome sequencing anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5205bdf9c69395bcf60ed6990ab118
https://doi.org/10.1016/j.semcdb.2020.04.017
https://doi.org/10.1016/j.semcdb.2020.04.017
Autor:
William T. Mahle, D. Woodrow Benson, Paul M. Kirshbom, Dennis M. McNamara, Nathan Salamacha, William A. Devine, Anne Moreau de Bellaing, Julie A. Phillippi, Thomas G. Gleason, Michael X. Wang, George C. Gabriel, Vidu Garg, Carrie Lee, Anastasia Miron, Wenjuan Zhu, Yijen L. Wu, Lazaros Kochilas, Cullen B. Young, Tuantuan Tan, Yihua He, Abha S. Bais, Jianhua Xing, Jonathan Klonowski, Hung Sing Li, Jianbin Wang, Peter White, Marie Billaud, Polakit Teekakirikul, Jingyu Zhang, Kylia Williams, Jiuann-huey Lin, Seema Mital, Leonid Emerel, Samuel K. Wyman, Tara D. Richards, Ankur Saini, Cecilia W. Lo, Erik Fung, Kim L. McBride, Jennifer C. Hill, Lisa J. Martin
Publikováno v:
HGG advances
HGG Advances, Vol 2, Iss 3, Pp 100037-(2021)
HGG Advances, Vol 2, Iss 3, Pp 100037-(2021)
Summary Bicuspid aortic valve (BAV) with ∼1%–2% prevalence is the most common congenital heart defect (CHD). It frequently results in valve disease and aorta dilation and is a major cause of adult cardiac surgery. BAV is genetically linked to rar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e8b5745ccd92d4b0433017b6509ad5
https://pubmed.ncbi.nlm.nih.gov/34888534
https://pubmed.ncbi.nlm.nih.gov/34888534
Autor:
Polakit, Teekakirikul, Wenjuan, Zhu, Xinxiu, Xu, Cullen B, Young, Tuantuan, Tan, Amanda M, Smith, Chengdong, Wang, Kevin A, Peterson, George C, Gabriel, Sebastian, Ho, Yi, Sheng, Anne, Moreau de Bellaing, Daniel A, Sonnenberg, Jiuann-Huey, Lin, Elisavet, Fotiou, Gennadiy, Tenin, Michael X, Wang, Yijen L, Wu, Timothy, Feinstein, William, Devine, Honglan, Gou, Abha S, Bais, Benjamin J, Glennon, Maliha, Zahid, Timothy C, Wong, Ferhaan, Ahmad, Michael J, Rynkiewicz, William J, Lehman, Bernard, Keavney, Tero-Pekka, Alastalo, Mary-Louise, Freckmann, Kyle, Orwig, Steve, Murray, Stephanie M, Ware, Hui, Zhao, Brian, Feingold, Cecilia W, Lo
Publikováno v:
Cell reports. Medicine. 3(2)
Analysis of large-scale human genomic data has yielded unexplained mutations known to cause severe disease in healthy individuals. Here, we report the unexpected recovery of a rare dominant lethal mutation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66a96a8f6f4f6f088b38eefad46ca14e
https://pubmed.ncbi.nlm.nih.gov/35243414
https://pubmed.ncbi.nlm.nih.gov/35243414
Autor:
Gennadiy Tenin, Sebastian Ho, Amanda M. Smith, Abha S. Bais, Xinxiu Xu, Yi Sheng, Tuantuan Tan, William Lehman, Brian Feingold, Kevin A. Peterson, Stephanie M. Ware, Mary-Louise Freckmann, Steve Murray, Anne Moreau de Bellaing, George C. Gabriel, Kyle E. Orwig, Hui Zhao, Ferhaan Ahmad, Cecilia W. Lo, Tero-Pekka Alastalo, Michael J. Rynkiewicz, Elisavet Fotiou, Wenjuan Zhu, Cullen B. Young, Chengdong Wang, Maliha Zahid, Daniel Sonnenberg, Timothy N. Feinstein, Polakit Teekakirikul, Jiuanne-huey Lin, Yijen L. Wu, Timothy C. Wong, Honglan Gou, William A. Devine, Bernard Keavney, Michael X. Wang
Publikováno v:
SSRN Electronic Journal.
Analysis of large scale human genomic data has yielded unexplained mutations known to cause severe disease in healthy individuals. Here we report the unexpected recovery of a rare dominant lethal mutation in TPM1, a sarcomeric actin-binding protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a464f780005944c110f13b4ab85d6aa
https://doi.org/10.2139/ssrn.3858980
https://doi.org/10.2139/ssrn.3858980
Autor:
Teresa M. Gunn, L. Aravind, Tejas S. Athni, Arunkumar Krishnan, Anne Moreau de Bellaing, William A. Devine, Jennifer H. Kong, Rajat Rohatgi, Sebastian Ho, Jiuann-Huey Ivy Lin, Chandni B. Patel, Cecilia W. Lo, Cullen B. Young, Ganesh V. Pusapati
Publikováno v:
Developmental cell. 55(4)
The etiology of congenital heart defects (CHDs), which are among the most common human birth defects, is poorly understood because of its complex genetic architecture. Here, we show that two genes implicated in CHDs, Megf8 and Mgrn1, interact genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a3333a8180a34bb60add27b7b39321
https://pubmed.ncbi.nlm.nih.gov/33232673
https://pubmed.ncbi.nlm.nih.gov/33232673