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Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation.

Autor: Tamura T; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan., Cheng C; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Stem Cell Biology Program, Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Villaseñor-Altamirano AB; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Yamada K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Ikeda K; Harvard Medical School, Boston, MA 02115, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Hayashida K; Harvard Medical School, Boston, MA 02115, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Menon JA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Chen XD; Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Chung H; Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Varon J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Chen J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Choi J; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Cullen AM; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Guo J; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Lin X; Harvard Medical School, Boston, MA 02115, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02142, USA., Olenchock BA; Harvard Medical School, Boston, MA 02115, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Pinilla-Vera MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Manandhar R; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Sheikh MDA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Hou PC; Harvard Medical School, Boston, MA 02115, USA.; Division of Emergency and Critical Care Medicine, Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Lawler PR; McGill University Health Centre, Montreal, Quebec H3A 2B4, Canada.; University of Toronto, Toronto, Ontario M5R 0A3, Canada., Oldham WM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Seethala RR; Harvard Medical School, Boston, MA 02115, USA.; Division of Emergency and Critical Care Medicine, Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Baron RM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Bohula EA; Harvard Medical School, Boston, MA 02115, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Morrow DA; Harvard Medical School, Boston, MA 02115, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Blumberg RS; Harvard Medical School, Boston, MA 02115, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02142, USA., Chen F; Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Merriam LT; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Weissman AJ; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Brenner MB; Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Ichinose F; Harvard Medical School, Boston, MA 02115, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Kim EY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Dec 04; Vol. 16 (776), pp. eadq5796. Date of Electronic Publication: 2024 Dec 04.

Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells.

Autor: Kim EY; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Ner-Gaon H; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Varon J; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Cullen AM; Division of Rheumatology, Inflammation and Immunity and., Guo J; Division of Rheumatology, Inflammation and Immunity and., Choi J; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA., Barragan-Bradford D; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA., Higuera A; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA., Pinilla-Vera M; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA., Short SA; Division of Renal (Kidney) Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Arciniegas-Rubio A; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA., Tamura T; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA., Leaf DE; Harvard Medical School, Boston, Massachusetts, USA.; Division of Renal (Kidney) Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Baron RM; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Masachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Shay T; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Brenner MB; Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Inflammation and Immunity and.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2020 Jun 01; Vol. 130 (6), pp. 3238-3252.