Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Cuilan, Nian"'
Autor:
Alex Z. Kadhim, Ben Vanderkruk, Samantha Mar, Meixia Dan, Katarina Zosel, Eric E. Xu, Rachel J. Spencer, Shugo Sasaki, Xuanjin Cheng, Shannon L. J. Sproul, Thilo Speckmann, Cuilan Nian, Robyn Cullen, Rocky Shi, Dan S. Luciani, Bradford G. Hoffman, Stefan Taubert, Francis C. Lynn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors to regulate development and maintain homeostasis. We observe reduced Mediator subunit MED15 expression in endocrin
Externí odkaz:
https://doaj.org/article/a99eab33e6ef46a1bcc1575a5001e336
Autor:
Carmen L. Bayly, Xiao-Qing Dai, Cuilan Nian, Paul C. Orban, C. Bruce Verchere, Patrick E. MacDonald, Francis C. Lynn
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102017- (2024)
Objective: Human embryonic stem cell (hESC; SC)-derived pancreatic β cells can be used to study diabetes pathologies and develop cell replacement therapies. Although current differentiation protocols yield SCβ cells with varying degrees of maturati
Externí odkaz:
https://doaj.org/article/fec9a33079604cce9f9fa718f5adb276
Autor:
Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107311- (2023)
Summary: Restoring functional β cell mass is a potential therapy for those with diabetes. However, the pathways regulating β cell mass are not fully understood. Previously, we demonstrated that Sox4 is required for β cell proliferation during pred
Externí odkaz:
https://doaj.org/article/4b4e9944c9d2462ca5dbfa7c24f73e0c
Autor:
Paul V. Sabatini, Thilo Speckmann, Cuilan Nian, Maria M. Glavas, Chi Kin Wong, Ji Soo Yoon, Tatsuya Kin, A.M. James Shapiro, William T. Gibson, C. Bruce Verchere, Francis C. Lynn
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 163-174 (2018)
Summary: Depolarization of neuroendocrine cells results in calcium influx, which induces vesicle exocytosis and alters gene expression. These processes, along with the restoration of resting membrane potential, are energy intensive. We hypothesized t
Externí odkaz:
https://doaj.org/article/7b8849adfc394379875cec3389786339
SummaryHuman embryonic stem cell (hESC)-derived pancreatic alpha and beta cells can be used to develop cell replacement therapies to treat diabetes. However, recent published differentiation protocols yield varying amounts of alpha and beta cells ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ae99d1ea18eb378a6dcf0420b49ecf
https://doi.org/10.1101/2023.04.19.537542
https://doi.org/10.1101/2023.04.19.537542
SummaryStem cell-derived β-cells (SCβ-cell) are a renewable and scalable alternative to cadaveric islets as a cell replacement therapy for type 1 diabetes (T1D). However, heterogeneity within SCβ-cell cultures remains problematic for graft safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f69737a2a7ba9572e6b525d48cf5bdd
https://doi.org/10.1101/2023.04.05.535733
https://doi.org/10.1101/2023.04.05.535733
Autor:
Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
ObjectiveDiabetes onset is accompanied with β-cell deficiency, and thus restoring functional β-cell mass is a promising therapy for those with diabetes. However, the regulatory mechanisms controlling β-cell mass are not fully understood. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb725225f32dfb659cbd0f108cd8ac6
https://doi.org/10.1101/2022.12.23.521810
https://doi.org/10.1101/2022.12.23.521810
Autor:
MARIA GALIPEAU, NATHALIE JOUVET, EMILIE COURTY, ROXANNE VANDENBEEK, NAVEEN P. KHAN, KHALIL BOUYAKDAN, CUILAN NIAN, CATERINA IORIO, DANIEL D. SCOTT, MAY FARAJ, MARLENE OEFFINGER, FRANCIS C. LYNN, ROBERT A. SCREATON, THIERRY ALQUIER, JENNIFER L. ESTALL
Publikováno v:
Diabetes. 71
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1A) is a nuclear transcriptional coregulator that plays a major role in the control of metabolism and mitochondrial biogenesis. We showed that a diabetes-linked single nucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::288665bef0af872ffafc6e50f031c59f
https://doi.org/10.2337/db22-299-or
https://doi.org/10.2337/db22-299-or
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 759-770 (2011)
Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that exerts insulinotropic and growth and survival effects on pancreatic β-cells. Additionally, there is increasing evidence supporting an important role for GIP in the
Externí odkaz:
https://doaj.org/article/5db4bfca0dc341fbb25cbd6c6d954862
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3145-3157 (2010)
GIP (glucose-dependent insulinotropic polypeptide) is a gastrointestinal hormone that regulates pancreatic islet function. Additionally, emerging evidence suggests an important physiological role for GIP in the regulation of adipocyte metabolism. In
Externí odkaz:
https://doaj.org/article/591ae8304c244c94868cf3e5c2a1c9b2