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Self-assembly of antifungal agent 5-fluorocytosine and nutrient trans-p-coumaric acid furnishes a cocrystal with the potential to reduce toxicity and side effects for the drug: a case study combining theory with experiment

Autor: Fan-Zhi Bu, Yue-Ming Yu, Yu Yu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: New Journal of Chemistry. 47:1328-1341

Cocrystallization of 5-fluorocytosine (FLCY) and trans-p-coumaric acid was first reported. Systematic studies combining theory with experiment revealed that both solubility and dissolution rate of FLCY can be down-regulated via cocrystallization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6c2a52f823d318835003fdef02c799a
https://doi.org/10.1039/d2nj03622c

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Salification-driven strategy toward the hydrophobic molecular salt of the antifungal drug 5-fluorocytosine and protocatechuic acid with triple-helix structure offers an innovative insight for conquering adverse drug reactions

Autor: Fan-Zhi Bu, Yue-Ming Yu, Lin-Lin Zhang, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: CrystEngComm. 25:1951-1964

The hydrophobic molecular salt of 5-fluorocytosine (FYT) with protocatechuic acid (PCA) was first reported, and its dissolution behaviors were systematically studied by combining theory with experiment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe0bfa6034005f00ebd025bebe624fb7
https://doi.org/10.1039/d2ce01523d

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Supramolecular self-assembly with p-coumaric acid offers the first cocrystal for perfecting the physicochemical peculiarity and enhancing the antifungal effect of drug bifonazole

Autor: Min Zhang, Min-Yu Wang, Yue-Ming Yu, Su-Su Meng, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: CrystEngComm. 25:2789-2801

The first cocrystal of bifonazole is assembled, and the pharmaceutical properties are investigated theoretically and experimentally, revealing that the physicochemical properties and antifungal ability are enhanced simultaneously.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2803a712c91a7d41f1555b71ac5fdc12
https://doi.org/10.1039/d3ce00082f

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5-fluorouracil-caffeic acid cocrystal delivery agent with long-term and synergistic high-performance antitumor effects

Autor: Yue-Ming Yu, Fan-Zhi Bu, Yu Yu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: Nanomedicine. 17:2215-2229

Aim: To explore how to transform cocrystals of the anticancer drug 5-fluorouracil (FL) with caffeic acid (CF; FL-CF-2H2O) into a nanoformulation, a self-assembly strategy of cocrystal-loaded micelles is proposed. Methods: Nanomicelles were assembled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f0321ab83c8a4b7ae62b7479a0c8702
https://doi.org/10.2217/nnm-2022-0208

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Cocrystallization-driven self-assembly with vanillic acid offers a new opportunity for surmounting fast and excessive absorption issues of antifungal drug 5-fluorocytosine: a combined theoretical and experimental research

Autor: Fan-Zhi Bu, Yue-Ming Yu, Yu-Li Shen, Lu Liu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: CrystEngComm. 24:2777-2790

The cocrystal of 5-fluorocytosine (FCY) with vanillic acid (VAA) was assembled via a cocrystallization technique, giving a novel understanding for conquering the dose-limited hepatotoxicity caused by the rapid and almost complete absorption of FCY.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8a61a4caa859c3cfff1d09b2818d426
https://doi.org/10.1039/d2ce00114d

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Cocrystallization of Amantadine Hydrochloride with Resveratrol: The First Drug–Nutraceutical Cocrystal Displaying Synergistic Antiviral Activity

Autor: Yue-Ming Yu, Yuan-Yuan Niu, Cui-Wei Yan, Yan-Tuan Li, Fan-Zhi Bu, Zhi-Yong Wu, Ming-Yu Zhao, Ling-Yang Wang

Publikováno v: Crystal Growth & Design. 21:2763-2776

In order to highlight the advantages of the nutraceutical resveratrol (RVA) in perfecting the in vitro/in vivo properties of amantadine hydrochloride (ATHC), to realize advantageous complementariti...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2a65f0154fc1affa3824304ae5e2810
https://doi.org/10.1021/acs.cgd.0c01673

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Supramolecular self-assembly of amantadine hydrochloride with ferulic acidviadual optimization strategy establishes a precedent of synergistic antiviral drug-phenolic acid nutraceutical cocrystal

Autor: Cui-Wei Yan, Ling-Yang Wang, Yue-Ming Yu, Yuan-Yuan Niu, Zhi-Yong Wu, Yan-Tuan Li, Ming-Yu Zhao

Publikováno v: The Analyst. 146:3988-3999

To display the capability of the phenolic acid nutraceutical ferulic acid (FLA) in optimizing the in vitro/in vivo properties of the antiviral drug amantadine hydrochloride (AMH) and achieve synergistically enhanced antiviral effects, thereby gaining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::396aefb6e0cd7fff27329dd1423f7d5c
https://doi.org/10.1039/d1an00478f

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