EP2/EP4 targeting prevents tumor-derived PGE2-mediated immunosuppression in cDC2s.

Autor: Cuenca-Escalona J; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Bödder J; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Subtil B; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Sánchez-Sánchez M; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Vidal-Manrique M; Laboratory of Hematology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands., Sweep MWD; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.; Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands., Fauerbach JA; R&D Reagents, Chemical Biology Department; Miltenyi Biotec B.V. & Co. KG, Friedrich-Ebert-Straße 68, 51429, Bergisch Gladbach, Germany., Cambi A; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., Flórez-Grau G; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands., de Vries JM; Department of Medical BioSciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2024 Nov 27; Vol. 116 (6), pp. 1554-1567.

cDC2 plasticity and acquisition of a DC3-like phenotype mediated by IL-6 and PGE2 in a patient-derived colorectal cancer organoids model.

Autor: Subtil B; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands., van der Hoorn IAE; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, the Netherlands., Cuenca-Escalona J; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands., Becker AMD; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands., Alvarez-Begue M; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands., Iyer KK; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands., Janssen J; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands., van Oorschot T; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands., Poel D; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands., Gorris MAJ; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands., van den Dries K; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands., Cambi A; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands., Tauriello DVF; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, the Netherlands., de Vries IJM; Department of Medical BioSciences (MBS), Radboud University Medical Center, Nijmegen, the Netherlands.

Publikováno v: European journal of immunology [Eur J Immunol] 2024 Jun; Vol. 54 (6), pp. e2350891. Date of Electronic Publication: 2024 Mar 21.

EP2 and EP4 blockade prevents tumor-induced suppressive features in human monocytic myeloid-derived suppressor cells.

Autor: Cuenca-Escalona J; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands., Subtil B; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands., Garcia-Perez A; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands., Cambi A; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands., de Vries IJM; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands., Flórez-Grau G; Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Jan 26; Vol. 15, pp. 1355769. Date of Electronic Publication: 2024 Jan 26 (Print Publication: 2024).

Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37.

Autor: Peeters R; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands., Cuenca-Escalona J; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands., Zaal EA; Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Hoekstra AT; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research, Utrecht University, Utrecht, The Netherlands., Balvert ACG; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands., Vidal-Manrique M; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands., Blomberg N; Metabolics Group, Leiden University Medical Centre, Leiden, The Netherlands., van Deventer SJ; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands., Stienstra R; Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Jellusova J; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany., Giera M; Metabolics Group, Leiden University Medical Centre, Leiden, The Netherlands., Hannibal L; Laboratory of Clinical Biochemistry and Metabolism, Department of General Paediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Centre - University of Freiburg, 79106, Freiburg, Germany., Spiekerkoetter U; Department of General Pediatrics, Adolescent Medicine and Neonatology, Faculty of Medicine, Medical Centre - University of Freiburg, 79106, Freiburg, Germany., Ter Beest M; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands., Berkers CR; Division of Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research, Utrecht University, Utrecht, The Netherlands., van Spriel AB; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands. Annemiek.vanspriel@radboudumc.nl.

Publikováno v: Nature communications [Nat Commun] 2022 Sep 13; Vol. 13 (1), pp. 5371. Date of Electronic Publication: 2022 Sep 13.

Tumor Biology Hides Novel Therapeutic Approaches to Diffuse Large B-Cell Lymphoma: A Narrative Review.

Autor: Masnikosa, Romana¹ (AUTHOR) david.piric@vin.bg.ac.rs, Cvetković, Zorica^2,3 (AUTHOR) romana@vin.bg.ac.rs, Pirić, David¹ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11384. 90p.