ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

Autor: Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH

Publikováno v: Cell
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Dendritic cells (DCs) are required to initiate and sustain T cell-dependent anti-cancer immunity. However, tumors often evade immune control by crippling normal DC function. The endoplasmic reticulum (ER) stress response factor XBP1 promotes intrinsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::dc110d15f4688e6d136bfe4f54b94852
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1803

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer.

Autor: Sandoval TA; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Salvagno C; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Chae CS; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Awasthi D; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Giovanelli P; Weill Cornell Graduate School of Medical Sciences, New York, New York., Marin Falco M; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Hwang SM; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Teran-Cabanillas E; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Suominen L; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Yamazaki T; Department of Radiation Oncology, Weill Cornell Medicine, New York, New York., Kuo HH; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Moyer JE; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Martin ML; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Manohar J; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Kim K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York., Sierra MA; Weill Cornell Graduate School of Medical Sciences, New York, New York., Ramos Y; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York., Tan C; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Emmanuelli A; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York.; Weill Cornell Graduate School of Medical Sciences, New York, New York., Song M; Departments of Integrative Biotechnology and of Biopharmaceutical Convergence, University of Suwon, Suwon, Korea., Morales DK; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York., Zamarin D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Frey MK; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Cantillo E; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Chapman-Davis E; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Holcomb K; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Mason CE; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, New York., Galluzzi L; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York.; Department of Radiation Oncology, Weill Cornell Medicine, New York, New York.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Ni Zhou Z; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York., Vähärautio A; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Foundation for the Finnish Cancer Institute, Helsinki, Finland., Cloonan SM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York.; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland., Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York.; Weill Cornell Graduate School of Medical Sciences, New York, New York.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Oct 04; Vol. 14 (10), pp. 1901-1921.

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1 ⁺ progenitor CD8 ⁺ T cells to improve immunotherapy.

Autor: Markowitz GJ; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA., Ban Y; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA., Tavarez DA; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Yoffe L; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Podaza E; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Gritstone Bio, Boston, MA, USA., He Y; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA., Martin MT; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA., Crowley MJP; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA.; SalioGen Therapeutics, Lexington, MA, USA., Sandoval TA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA., Gao D; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Martin ML; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Altos Labs, Redwood City, CA, USA., Elemento O; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Cubillos-Ruiz JR; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA., McGraw TE; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA., Altorki NK; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Mittal V; Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA. vim2010@med.cornell.edu.; Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY, USA. vim2010@med.cornell.edu.; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA. vim2010@med.cornell.edu.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA. vim2010@med.cornell.edu.; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA. vim2010@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. vim2010@med.cornell.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Oct; Vol. 25 (10), pp. 1884-1899. Date of Electronic Publication: 2024 Sep 26.

Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia.

Autor: Fernández JJ; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular, CSIC-Universidad de Valladolid, 47003, Valladolid, Spain., Mancebo C; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular, CSIC-Universidad de Valladolid, 47003, Valladolid, Spain.; Departamento de Bioquímica, Biología Molecular y Fisiología, Universidad de Valladolid, 47003, Valladolid, Spain., Garcinuño S; Servicio de Microbiología, Hospital Clínico Universitario de Valladolid, Universidad de Valladolid, 47003, Valladolid, Spain., March G; Servicio de Microbiología, Hospital Clínico Universitario de Valladolid, Universidad de Valladolid, 47003, Valladolid, Spain., Alvarez Y; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular, CSIC-Universidad de Valladolid, 47003, Valladolid, Spain.; Departamento de Bioquímica, Biología Molecular y Fisiología, Universidad de Valladolid, 47003, Valladolid, Spain., Alonso S; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular, CSIC-Universidad de Valladolid, 47003, Valladolid, Spain., Inglada L; Servicio de Medicina Interna, Hospital Universitario Rio-Hortega, 47012, Valladolid, Spain., Blanco J; Servicio de Medicina Intensiva, Hospital Universitario Rio-Hortega, 47012, Valladolid, Spain.; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain., Orduña A; Servicio de Microbiología, Hospital Clínico Universitario de Valladolid, Universidad de Valladolid, 47003, Valladolid, Spain., Montero O; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular, CSIC-Universidad de Valladolid, 47003, Valladolid, Spain., Sandoval TA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, 10065, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA., Cubillos-Ruiz JR; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, 10065, USA.; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA., Bustamante-Munguira E; Servicio de Medicina Intensiva, Hospital Clínico Universitario de Valladolid, 47003, Valladolid, Spain., Fernández N; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular, CSIC-Universidad de Valladolid, 47003, Valladolid, Spain.; Departamento de Bioquímica, Biología Molecular y Fisiología, Universidad de Valladolid, 47003, Valladolid, Spain., Crespo MS; Unidad de Excelencia Instituto de Biomedicina y Genética Molecular, CSIC-Universidad de Valladolid, 47003, Valladolid, Spain. sanchezcrespomariano@gmail.com.

Publikováno v: Genes and immunity [Genes Immun] 2024 Feb; Vol. 25 (1), pp. 43-54. Date of Electronic Publication: 2023 Dec 25.

Transgelin 2 guards T cell lipid metabolic programming and anti-tumor function.

Autor: Hwang SM; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Awasthi D; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Jeong J; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., Sandoval TA; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Chae CS; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Ramos Y; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA., Tan C; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Falco MM; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland., McBain IT; Weill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA., Mishra B; Weill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA., Ivashkiv LB; Weill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.; HSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA., Zamarin D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cantillo E; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Chapman-Davis E; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Holcomb K; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Morales DK; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute. Tampa, FL, USA., Conejo-Garcia JR; Department of Integrated Immunobiology, Duke School of Medicine, Durham, NC 27710, USA.; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Kaczocha M; Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, USA.; Stony Brook University Pain and Analgesia Research Center (SPARC), Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Vähärautio A; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Foundation for the Finnish Cancer Institute, Helsinki, Finland., Song M; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA., Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine. New York, NY 10065, USA.; Weill Cornell Graduate School of Medical Sciences. New York, NY 10065. USA.

Publikováno v: Research square [Res Sq] 2023 Dec 14. Date of Electronic Publication: 2023 Dec 14.