A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes.

Autor: Colombo G; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Cubero RJA; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Kanari L; Blue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland., Venturino A; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Schulz R; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Scolamiero M; Department of Mathematics, KTH Royal Institute of Technology, Stockholm, Sweden., Agerberg J; Department of Mathematics, KTH Royal Institute of Technology, Stockholm, Sweden., Mathys H; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; University of Pittsburgh Brain Institute and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Chachólski W; Department of Mathematics, KTH Royal Institute of Technology, Stockholm, Sweden., Hess K; Laboratory for Topology and Neuroscience, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Siegert S; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria. ssiegert@ist.ac.at.

Publikováno v: Nature neuroscience [Nat Neurosci] 2022 Oct; Vol. 25 (10), pp. 1379-1393. Date of Electronic Publication: 2022 Sep 30.

Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.

Autor: Venturino A; Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria., Schulz R; Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria., De Jesús-Cortés H; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Maes ME; Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria., Nagy B; Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria., Reilly-Andújar F; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Colombo G; Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria., Cubero RJA; Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria., Schoot Uiterkamp FE; Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria., Bear MF; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Siegert S; Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria. Electronic address: sandra.siegert@ist.ac.at.

Publikováno v: Cell reports [Cell Rep] 2021 Jul 06; Vol. 36 (1), pp. 109313.