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pro vyhledávání: '"Csx3"'
Autor:
Brown, Sharidan, Gauvin, Colin C., Charbonneau, Alexander A., Burman, Nathaniel, Lawrence, C. Martin *
Publikováno v:
In Journal of Biological Chemistry 30 October 2020 295(44):14963-14972
Akademický článek
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Akademický článek
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Autor:
Sharidan Brown, C. Martin Lawrence, Nathaniel Burman, Alexander A. Charbonneau, Colin C. Gauvin
Publikováno v:
J Biol Chem
Cas10 is the signature gene for type III CRISPR–Cas surveillance complexes. Unlike type I and type II systems, type III systems do not require a protospacer adjacent motif and target nascent RNA associated with transcriptionally active DNA. Further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c7b2a3407a6bb19d137fad41e64a9e
https://europepmc.org/articles/PMC7606696/
https://europepmc.org/articles/PMC7606696/
Autor:
Sabine Grüschow, Malcolm F. White, Tracey M. Gloster, Januka S Athukoralage, Shirley Graham, Stuart McQuarrie
Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff85a643332ecc71b1531901ed733df1
https://doi.org/10.1101/2020.04.28.066118
https://doi.org/10.1101/2020.04.28.066118
Autor:
Ece Topuzlu, C. Martin Lawrence
Publikováno v:
RNA Biology. 13:254-257
The CRISPR/Cas adaptive immune system shows extreme diversity in the number of CRISPR/Cas types and subtypes, and in the multitude of CRISPR associated protein families of which they are composed. Despite this diversity, the roles of many Cas protein
In prokaryotes, the CRISPR/Cas system is known to target and degrade invading phages and foreign genetic elements upon subsequent infection. However, the structure and function of many Cas proteins remain largely unknown, due to the high diversity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8cfb75af7ae7f238688eaf17ab20cf
https://europepmc.org/articles/PMC4615834/
https://europepmc.org/articles/PMC4615834/
Autor:
Januka S Athukoralage, Stuart McQuarrie, Sabine Grüschow, Shirley Graham, Tracey M Gloster, Malcolm F White
Publikováno v:
eLife, Vol 9 (2020)
Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid o
Externí odkaz:
https://doaj.org/article/0d1373e96dfd4832a55e12e447f7ab9a
Autor:
Stuart McQuarrie, Shirley Graham, Malcolm F. White, Sabine Grüschow, Tracey M. Gloster, Januka S Athukoralage
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Type III CRISPR systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic oligoadenylate (cOA) molecules that act as a second messenger to signal infection, activating nucleases that degrade the nucleic acid o
Autor:
Wenyuan Han, Shiraz A. Shah, Omer S. Alkhnbashi, Qunxin She, Juliane Behler, Wolfgang R. Hess, Roger A. Garrett, Rolf Backofen
Publikováno v:
RNA Biology
Shah, S A, Alkhnbashi, O S, Behler, J, Han, W, She, Q, Hess, W R, Garrett, R A & Backofen, R 2019, ' Comprehensive search for accessory proteins encoded with archaeal and bacterial type III CRISPR-cas gene cassettes reveals 39 new cas gene families ', RNA Biology, vol. 16, no. 4, pp. 530-542 . https://doi.org/10.1080/15476286.2018.1483685
Shah, S A, Alkhnbashi, O S, Behler, J, Han, W, She, Q, Hess, W R, Garrett, R A & Backofen, R 2019, ' Comprehensive search for accessory proteins encoded with archaeal and bacterial type III CRISPR-cas gene cassettes reveals 39 new cas gene families ', RNA Biology, vol. 16, no. 4, pp. 530-542 . https://doi.org/10.1080/15476286.2018.1483685
A study was undertaken to identify conserved proteins that are encoded adjacent to cas gene cassettes of Type III CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats – CRISPR associated) interference modules. Type III modules have