Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Csilla Sepsey Für"'
Autor:
Csilla Sepsey Für, Hedvig Bölcskei
Publikováno v:
Chemistry, Vol 2, Iss 4, Pp 837-848 (2020)
The large originator pharmaceutical companies need more and more new compounds for their molecule banks, because high throughput screening (HTS) is still a widely used method to find new hits in the course of the lead discovery. In the design and syn
Externí odkaz:
https://doaj.org/article/56b19b4304294b6a86f5db470d3c2ce0
Publikováno v:
Molbank, Vol 2021, Iss 3, p M1243 (2021)
After making a new series of spiro[cycloalkane]pyridazinones with high Fsp3 character available, the new target was to synthesize derivatives comprising nitrogen-containing heterocycles, such as triazolo or tetrazolo rings. The corresponding thioxo d
Externí odkaz:
https://doaj.org/article/77df7ad789f04fed850650c081c2366f
Autor:
Csilla Sepsey Für, Gergő Riszter, Áron SzigetvárI, Miklós Dékány, György Keglevich, László HazaI, Hedvig BölcskeI
Publikováno v:
Molecules, Vol 26, Iss 8, p 2140 (2021)
In orderto synthesize new pyridazine derivatives anellated with different nitrogen heterocyclic moieties, spiro[cycloalkane]pyridazinones were transformed into the corresponding thioxo derivatives via a reaction with phosphorus pentasulfide. The reac
Externí odkaz:
https://doaj.org/article/98816ce554054d99be10765e0dd6a855
Autor:
Miklós Dékány, Áron Szigetvári, Csilla Sepsey Für, László Hazai, György Keglevich, Eszter Judit Horváth, Hedvig Bölcskei
Publikováno v:
Letters in Organic Chemistry. 18:373-381
Abstract: An extended compound library of spiro[cycloalkane-pyridazinones] with a high Fsp3 character is targeted. There are two possibilities to improve the physicochemical parameters of a drug candidate molecules or building blocks, either to repla
Autor:
György Keglevich, Zsuzsanna Szalai, Kinga V. Gulyás, Róbert Zahár, Alajos Grün, Csilla Sepsey Für
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 197:520-522
Autor:
Csilla Sepsey Für, Viktor Ilkei, Szabolcs Mayer, Hedvig Bölcskei, András Keglevich, László Hazai, Péter Keglevich
Publikováno v:
Chemistry. 2:714-726
The antitumor indole–indoline alkaloids of the evergreen Catharanthus roseus—namely vinblastine and vincristine—are widely used in chemotherapy of cancer. Many efforts were made to synthesize more efficient derivatives with less side-effect. Th
Autor:
Miklós Dékány, Áron Szigetvári, János Gerencsér, Gergo Riszter, Csilla Sepsey Für, Hedvig Bölcskei, László Hazai, György Keglevich
Publikováno v:
Letters in Drug Design & Discovery. 17:731-744
Background: owadays, in course of the drug design and discovery much attention is paid to the physicochemical parameters of a drug candidate, in addition to their biological activity. Disadvantageous physicochemical parameters can hinder the success
Publikováno v:
Magyar Kémiai Folyóirat. 124:71-77
Publikováno v:
Molbank, Vol 2021, Iss M1243, p M1243 (2021)
After making a new series of spiro[cycloalkane]pyridazinones with high Fsp3 character available, the new target was to synthesize derivatives comprising nitrogen-containing heterocycles, such as triazolo or tetrazolo rings. The corresponding thioxo d