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pro vyhledávání: '"Csanad M. Varga"'
Autor:
Alexander M. Klibanov, Linda G. Griffith, Nathan C. Tedford, Csanad M. Varga, Douglas A. Lauffenburger, Mini Thomas
Publikováno v:
Gene Therapy. 12:1023-1032
An objective of designing molecular vehicles exhibiting virus-like transgene delivery capabilities but with low toxicity and immunogenicity continues to drive synthetic vector development. As no single step within the gene delivery pathway represents
Publikováno v:
Molecular Therapy. 4(5):438-446
As intracellular gene delivery pathways are highly complex combinations of multiple potentially rate-limiting cellular and molecular processes, approaches to the design of synthetic delivery vectors focusing on any single barrier individually will li
Publikováno v:
Biotechnology and Bioengineering. 70:593-605
One way to deliver transgenes to cells in a selective manner is to target the delivery vehicles, or vectors, to specific cell-surface receptors as a first step toward ulimate transport of the gene to the nucleus for expression. While selective delive