Výsledky vyhledávání - "Csaba F. László"

Inhibition of hypoxia-inducible transcription factor complex with designed epipolythiodiketopiperazine

Autor: Lajos Szabo, Bogdan Olenyuk, Csaba F. László, Swati Kushal, Hui Wang

Publikováno v: Biopolymers. 95:8-16

Designed small molecule inhibitors of hypoxia-inducible gene expression have potential to become new research tools for molecular biology, genetics and serve as leads to new therapeutics. We report design, synthesis evaluation of biological activity,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492ebef0b05d10ecba53400f4906f8cf
https://doi.org/10.1002/bip.21550

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The Role of Nitric-oxide Synthase in the Regulation of UVB Light-induced Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2

Autor: Shiyong Wu, Wei Lu, Zhixin Miao, Hao Chen, Csaba F. László

Publikováno v: Journal of Biological Chemistry. 284:24281-24288

UV light induces phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha) and inhibits global protein synthesis. Both eIF2 kinases, protein kinase-like endoplasmic reticulum kinase (PERK) and general control of nonderepr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6012417d6404db8cee314867005a5cb8
https://doi.org/10.1074/jbc.m109.008821

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The role of translational regulation in ultraviolet C light-induced cyclooxygenase-2 expression

Autor: Sherine Fayad, Csaba F. László, Kimberly S. George, Shiyong Wu, Wei Lu, Abir A. Saad, Oliver L. Carpenter

Publikováno v: Life Sciences. 85:70-76

The role of ultraviolet C light (UVC)-induced phosphorylation of the eukaryotic initiation factor 2 (eIF2) in the regulation of cyclooxygenase-2 (COX-2) expression at both transcriptional and translational levels is investigated.Western analysis was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f012dc99931dbc41f59a6fea93cd7ad
https://doi.org/10.1016/j.lfs.2009.04.018

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Mechanism of UV-Induced IκBα-Independent Activation of NF-κB

Autor: Shiyong Wu, Csaba F. László

Publikováno v: Photochemistry and Photobiology. 84:1564-1568

Nuclear factor-kappa B (NF-kappaB) plays an important role in UV-induced skin tumorigenesis. Activation of NF-kappaB by UV-irradiation is composed of two phases. The early phase culminates with maximal levels of DNA binding ability at 4 h postirradia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11d3c106e517ad242f09bca7f456b5eb
https://doi.org/10.1111/j.1751-1097.2008.00385.x

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Nucleolin Mediates MicroRNA-directed CSF-1 mRNA Deadenylation but Increases Translation of CSF-1 mRNA*

Autor: Setsuko K. Chambers, Terri Baker, Csaba F. László, Ho Hyung Woo

CSF-1 mRNA 3′UTR contains multiple unique motifs, including a common microRNA (miRNA) target in close proximity to a noncanonical G-quadruplex and AU-rich elements (AREs). Using a luciferase reporter system fused to CSF-1 mRNA 3′UTR, disruption o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f3b5e927e26a4f9f55e83a3840e040
https://europepmc.org/articles/PMC3675821/

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Suppression of tumor growth by designed dimeric epidithiodiketopiperazine targeting hypoxia-inducible transcription factor complex

Autor: Jason B. Singh, Ramin Dubey, Jan E. Schnitzer, Bogdan Olenyuk, Lajos Szabo, Csaba F. László, Philip Oh, Swati Kushal, Michael D. Levin

Publikováno v: Journal of the American Chemical Society. 135(11)

Hypoxia is a hallmark of solid tumors, is associated with local invasion, metastatic spread, resistance to chemo- and radiotherapy, and is an independent, negative prognostic factor for a diverse range of malignant neoplasms. The cellular response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8484f7e6cbe1e0620c005fabf153857
https://pubmed.ncbi.nlm.nih.gov/23448368

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Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine

Autor: Katherine M. Block, Hui Wang, Nathan W. Polaske, Zuohe Song, Laura K. Henchey, Joshua Makhoul, Swati Kushal, Bogdan Olenyuk, Lajos Szabo, Ramin Dubey, Emmanuelle J. Meuillet, Csaba F. László

Publikováno v: Journal of the American Chemical Society. 131(50)

Selective blockade of hypoxia-inducible gene expression by designed small molecules would prove valuable in suppressing tumor angiogenesis, metastasis and altered energy metabolism. We report the design, synthesis, and biological evaluation of a dime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8866e07c4ade783e1c069db265d1537c
https://pubmed.ncbi.nlm.nih.gov/20000859

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