Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cs. Tömböly"'
Autor:
Dirk Tourwé, Stefania Meini, Steven Ballet, P. Cucchi, Laura Quartara, Cs. Tömböly, K. Van Rompaey, Debby Feytens, R. De Wachter, Géza Tóth
Publikováno v:
Journal of Peptide Science. 13:164-170
High affinity peptide ligands for the bradykinin (BK) B2 subtype receptor have been shown to adopt a β-turn conformation of the C-terminal tetrapeptide (H-Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9-OH). We investigated the replacement of the Pro7-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee82a18b13f16ab8da82e7ca0422ee0
https://doi.org/10.1002/psc.827
https://doi.org/10.1002/psc.827
Autor:
Cs. Tömböly, Eva V. Varga, William R. Roeske, Edita Navratilova, Anna Borsodi, Dirk Tourwé, Henry I. Yamamura, Mária Szücs, Ferenc Fülöp, Géza Tóth, Antal Péter, Attila Keresztes
Publikováno v:
Pure and Applied Chemistry. 76:951-957
Endomorphins (endomorphin-1,H-Tyr-Pro-Trp-Phe-NH 2 ,endomorphin-2, Tyr-Pro-Phe-Phe-NH2) are potent and selective µ-opioid receptor agonists. In order to improve the affinity and chemical stability of endomorphins, we have designed, synthesized, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44dc556f4d04a035336cbdc416a4109f
https://doi.org/10.1351/pac200476050951
https://doi.org/10.1351/pac200476050951
Autor:
László Kocsis, Cs. Tömböly, Dauren Biyashev, Zs. Fürst, András Z. Rónai, Imre Lengyel, Mahmoud Al-Khrasani, Anna Borsodi, György Orosz, Géza Tóth
Publikováno v:
Biochemical and Biophysical Research Communications. 290:153-161
Side chain modifications were introduced to endomorphin 2 (E2) to improve its binding properties and biological activity. A number of C-terminal modifications decreased the binding affinity to the mu-opioid receptor and the intrinsic activity in rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364495a516b14990e3392cf4ced0118a
https://doi.org/10.1006/bbrc.2001.6136
https://doi.org/10.1006/bbrc.2001.6136
Publikováno v:
Annals of the New York Academy of Sciences. 897:154-164
Spinal analgesic effects of endomorphin-1 and endomorphin-2 were studied during acute, inflammatory, and neuropathic pain in rats chronically implanted with intrathecal cannulas. Endomorphin-1 and endomorphin-2 (2.5-10 micrograms i.t.), as well as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb07d41105adeda64515403db5b99a41
https://doi.org/10.1111/j.1749-6632.1999.tb07887.x
https://doi.org/10.1111/j.1749-6632.1999.tb07887.x
Publikováno v:
Czechoslovak Journal of Physics. 49:893-896
Endomorphine I (Tyr-Pro-Trp-Phe-NH2) and endomorphin II (Tyr-Pro-Phe-Phe-NH2) are recently isolated neuropeptides. They have the highest specificity and affinity for the μ-opiate receptor among all the endogenous substances so far described, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adeca1958e221191a09d4db4a4a381b6
https://doi.org/10.1007/s10582-999-1014-3
https://doi.org/10.1007/s10582-999-1014-3
Autor:
Dirk Tourwé, N. De Kimpe, K. Van Rompaey, Gábor Tóth, Gyula Wittmann, Cs. Tömböly, José C. Martins
Publikováno v:
The Journal of organic chemistry. 66(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a59d872ebc6aaeb6dd0526e0fee201
https://pubmed.ncbi.nlm.nih.gov/11304220
https://pubmed.ncbi.nlm.nih.gov/11304220
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