Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Crystal Y. Chen"'
Autor:
William R. Jacobs, James Frencher, Zheng W. Chen, Dan Huang, Arwa Qaqish, Steven A. Porcelli, Wandang Wang, Hongbo Shen, Richard Wang, Zhuoran Zhang, Crystal Y. Chen, Enzhuo Yang, Ling Shen, Michelle H. Larsen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite the urgent need for a better tuberculosis (TB) vaccine, relevant protective mechanisms remain unknown. We previously defined protective phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP)–specific Vγ2Vδ2 T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9a8daf77e9b96b21c20c1ee866198d
http://europepmc.org/articles/PMC6442559
http://europepmc.org/articles/PMC6442559
Autor:
Zhuoran Zhang, Hongbo Shen, Crystal Y. Chen, Ming Guo, Enzhuo Yang, Wenzhe Ho, Heping Xiao, Rui Yang, Wandang Wang, Dan Huang, Zheng W. Chen, Ling Shen, Feifei Wang
Publikováno v:
Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-12 (2018)
Emerging Microbes & Infections
Emerging Microbes & Infections
Tuberculosis (TB) has become the most deadly infectious diseases due to epidemics of HIV/AIDS and multidrug-resistant/extensively drug-resistant TB (MDR-/XDR-TB). Although person-to-person transmission contributes to MDR-TB, it remains unknown whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a961e15f4b96e53a2ec1be6833d7c52
http://link.springer.com/article/10.1038/s41426-018-0213-z
http://link.springer.com/article/10.1038/s41426-018-0213-z
Autor:
Crystal Y Chen, Shuyu Yao, Dan Huang, Huiyong Wei, Helene Sicard, Gucheng Zeng, Hassan Jomaa, Michelle H Larsen, William R Jacobs, Richard Wang, Norman Letvin, Yun Shen, Liyou Qiu, Ling Shen, Zheng W Chen
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003501 (2013)
Dominant Vγ2Vδ2 T-cell subset exist only in primates, and recognize phosphoantigen from selected pathogens including M. tuberculosis(Mtb). In vivo function of Vγ2Vδ2 T cells in tuberculosis remains unknown. We conducted mechanistic studies to det
Externí odkaz:
https://doaj.org/article/eac0ccc4d00d4d9cba7341288e715a71
Autor:
Dan Huang, Crystal Y Chen, Meihong Zhang, Liyou Qiu, Yun Shen, George Du, Keyuan Zhou, Richard Wang, Zheng W Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30631 (2012)
We previously demonstrated that unvaccinated macaques infected with large-dose M.tuberculosis(Mtb) exhibited delays for pulmonary trafficking of Ag-specific αβ and γδ T effector cells, and developed severe lung tuberculosis(TB) and "secondary" Mt
Externí odkaz:
https://doaj.org/article/83ffe111ad2e45d8a3cc0a235026f12b
Autor:
Yueqin Qiu, Jianbo Chen, Hongying Liao, Yan Zhang, Hua Wang, Shaoyuan Li, Yanfen Luo, Danyun Fang, Guobao Li, Boping Zhou, Ling Shen, Crystal Y Chen, Dan Huang, Jiye Cai, Kaiyuan Cao, Lifang Jiang, Gucheng Zeng, Zheng W Chen
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1002984 (2012)
T-cell immune responses modulated by T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) during Mycobacterium tuberculosis (Mtb) infection in humans remain poorly understood. Here, we found that active TB patients exhibited increases
Externí odkaz:
https://doaj.org/article/d6a5e5bde6ea480085f0b43c4f4feff4
Autor:
Shuyu Yao, Dan Huang, Crystal Y Chen, Lisa Halliday, Gucheng Zeng, Richard C Wang, Zheng W Chen
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000789 (2010)
Differentiation, distribution and immune regulation of human IL-22-producing T cells in infections remain unknown. Here, we demonstrated in a nonhuman primate model that M. tuberculosis infection resulted in apparent increases in numbers of T cells c
Externí odkaz:
https://doaj.org/article/4c58817a605d4388865c90d852664d51
Autor:
Huiyong Wei, Richard Wang, Zhuqing Yuan, Crystal Y Chen, Dan Huang, Lisa Halliday, Weihua Zhong, Gucheng Zeng, Yun Shen, Ling Shen, Yunqi Wang, Zheng W Chen
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6905 (2009)
In vivo kinetics and frequencies of epitope-specific CD4 T cells in lymphoid compartments during M. tuberculosis infection and their resting memory pool after BCG vaccination remain unknown.Macaque DR*W201 tetramer loaded with Ag85B peptide 65 was de
Externí odkaz:
https://doaj.org/article/89c9cb96030649f0819276bff8eb5768
Autor:
Crystal Y Chen, Dan Huang, Richard C Wang, Ling Shen, Gucheng Zeng, Shuyun Yao, Yun Shen, Lisa Halliday, Jeff Fortman, Milton McAllister, Jim Estep, Robert Hunt, Daphne Vasconcelos, George Du, Steven A Porcelli, Michelle H Larsen, William R Jacobs, Barton F Haynes, Norman L Letvin, Zheng W Chen
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000392 (2009)
The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number o
Externí odkaz:
https://doaj.org/article/770745e351f84c4e98826b1bfc2de41d
Autor:
Yang Lu, James Frencher, Michelle H. Larsen, Shengpu Li, Zhuoran Zhang, Zheng W. Chen, Enzhuoa Yang, Lixia Qian, William R. Jacobs, Richard Wang, Dan Huang, Arwa Qaqish, Crystal Y. Chen, Ling Shen
Publikováno v:
The Journal of Immunology. 198:4753-4763
The dominant Vγ2Vδ2 T cell subset recognizes phosphoantigen and exists only in humans and nonhuman primates. Despite the discovery of γδ T cells >30 y ago, a proof-of-concept study has not been done to prove the principle that the Vγ2Vδ2 T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bc87b5038b205de77d5e058f98b9a0
https://doi.org/10.4049/jimmunol.1602019
https://doi.org/10.4049/jimmunol.1602019
Autor:
Crystal Y. Chen, Dan Huang, Chunmiao Hu, Zheng W. Chen, Jiye Cai, Richard Wang, Jiang Pi, Hongbo Shen, Enzhuo Yang, Ling Shen, Gucheng Zeng, Bao-Shiang Lee, Wandang Wang, Hua Jin
Publikováno v:
Materials scienceengineering. C, Materials for biological applications. 103
Tuberculosis (TB), caused by M.tuberculosis (Mtb), has become a top killer among infectious diseases. Enhancing the ability of anti-TB drugs to kill intracellular Mtb in host cells remains a big challenge. Here, an innovative nano-system was develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837a505632ba780ee4e7030dfa565699
https://pubmed.ncbi.nlm.nih.gov/31349400
https://pubmed.ncbi.nlm.nih.gov/31349400