Výsledky vyhledávání - "Crystal R. White"

Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner

Autor: Tu Hsueh Yeh, Da Yong Lee, Ryan J. Emnett, David H. Gutmann, Crystal R. White

Publikováno v: Genes & Development. 24:2317-2329

Recent studies have shown that neuroglial progenitor/stem cells (NSCs) from different brain regions exhibit varying capacities for self-renewal and differentiation. In this study, we used neurofibromatosis-1 (NF1) as a model system to elucidate a nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d66b07e902a1541251dcc1519f51ec3
https://doi.org/10.1101/gad.1957110

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Loss of the Protein NUPR1 (p8) Leads to Delayed LHB Expression, Delayed Ovarian Maturation, and Testicular Development of a Sertoli-Cell-Only Syndrome-Like Phenotype in Mice1

Autor: Michael W. King, Phillip L. Quirk, Crystal R. White, Juan L. Iovanna, Christine C. Quirk, Christina M. Million Passe

Publikováno v: Biology of Reproduction. 79:598-607

The high mobility group factor NUPR1, also known as p8 and com1, plays a role in temporal expression of the beta subunit of luteinizing hormone, LHB, during gonadotroph development. At Embryonic Day (e) 16.5, LHB is detectable in wild-type (Nupr1+/+)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8e018864ce35ff203c47bb879d01489
https://doi.org/10.1095/biolreprod.108.068304

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Expression of the high mobility group A family member p8 is essential to maintaining tumorigenic potential by promoting cell cycle dysregulation in LβT2 cells

Autor: C. M. Million Passe, K. M. Brannon, Christine C. Quirk, Michael W. King, Crystal R. White, N. A. Bade

Publikováno v: Cancer Letters. 254:146-155

The mechanism by which the HMGA protein p8 facilitates tumorigenesis may be cell cycle dysregulation. Control- (C) LbetaT2 cells, which express p8, form tumors at a rate five-times faster than p8-knockdown (p8-KD)-LbetaT2 cells. In association with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6eba81b0c77858508d32d13ed19240f
https://doi.org/10.1016/j.canlet.2007.03.011

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Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth

Autor: Fausto J. Rodriguez, Winnie W. Pong, Crystal R. White, Grant W. Simmons, David H. Gutmann, Scott M. Gianino, Ryan J. Emnett

Publikováno v: Journal of neuropathology and experimental neurology. 70(1)

While carcinogenesis requires the acquisition of driver mutations in progenitor cells, tumor growth and progression is heavily influenced by the local microenvironment. Previous studies from our laboratory have employed Neurofibromatosis-1 (NF1) gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361ccdf93731f3b1193c6d2eaf38e90d
https://pubmed.ncbi.nlm.nih.gov/21157378

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Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice

Autor: Karen L. O'Malley, Crystal R. White, David H. Gutmann, Jacquelyn A. Brown, Carla M. Yuede, David F. Wozniak, Sara Conyers, Ryan J. Emnett

Publikováno v: Human molecular genetics. 19(22)

Learning and behavioral abnormalities are among the most common clinical problems in children with the neurofibromatosis-1 (NF1) inherited cancer syndrome. Recent studies using Nf1 genetically engineered mice (GEM) have been instructive for partly el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d30cd4284189bedd7c466e327ce96a6
https://pubmed.ncbi.nlm.nih.gov/20826448

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