Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Crystal McGirr"'
Autor:
Kavita Bisht, Joshua Tay, Rebecca N. Wellburn, Crystal McGirr, Whitney Fleming, Bianca Nowlan, Valerie Barbier, Ingrid G. Winkler, Jean-Pierre Levesque
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic
Externí odkaz:
https://doaj.org/article/ff12dcb49dd94ebabbf3b487e364337d
Autor:
Kavita Bisht, Gerhard Müller-Newen, Taichi Matsumoto, Jean-Pierre Levesque, Crystal McGirr, Kylie A. Alexander, Ingrid G. Winkler, Seo-Youn Lee, Whitney Fleming, Valerie Barbier, Natalie A. Sims, Hsu-Wen Tseng, Halvard Bonig
Publikováno v:
Leukemia. 36:333-347
We show that pro-inflammatory oncostatin M (OSM) is an important regulator of hematopoietic stem cell (HSC) niches in the bone marrow (BM). Treatment of healthy humans and mice with granulocyte colony-stimulating factor (G-CSF) dramatically increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a82c5211d7231c8320c6f6a6c78a6fc
https://doi.org/10.1038/s41375-021-01413-z
https://doi.org/10.1038/s41375-021-01413-z
Autor:
Allison R. Pettit, Ingrid G. Winkler, Jean-Pierre Levesque, Crystal McGirr, Susan M. Millard, Kavita Bisht, Joshua Tay
Publikováno v:
Experimental Hematology. 82:33-42
The erythroblastic island (EBI) is a multicellular structure forming an erythropoietic niche consisting of a central macrophage surrounded by a rosette of maturing erythroblasts. Since their discovery more than 60 years ago, simultaneous quantificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285f89782121c07126bd858b9f8a8336
https://doi.org/10.1016/j.exphem.2020.02.003
https://doi.org/10.1016/j.exphem.2020.02.003
Autor:
Andrew C. Perkins, Ingrid G. Winkler, Thomas Keech, Marion E. G. Brunck, Whitney Fleming, Gail Walkinshaw, Taichi Matsumoto, Jean-Pierre Levesque, Julie M. Davies, Kavita Bisht, Bianca Nowlan, Graham Magor, Crystal McGirr, Lee A. Flippin
Publikováno v:
Blood Advances. 3:406-418
In normoxia, hypoxia-inducible transcription factors (HIFs) are rapidly degraded within the cytoplasm as a consequence of their prolyl hydroxylation by oxygen-dependent prolyl hydroxylase domain (PHD) enzymes. We have previously shown that hematopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723ae274401a19004dd45bd902268a1b
https://doi.org/10.1182/bloodadvances.2018017566
https://doi.org/10.1182/bloodadvances.2018017566
Autor:
Jenny N. Fung, Trent M. Woodruff, Barbara E. Rolfe, Keith Weng Kit Leong, Paul C. Mills, Helga D. Manthey, Jamileh A. Nabizadeh, Stefan Eugen Sonderegger, Mohd Hezmee Mohd Noor, Fazrena Nadia Md Akhir, Ian A. Shiels, Crystal McGirr
Publikováno v:
Antibodies
Volume 10
Issue 1
Antibodies, Vol 10, Iss 2, p 2 (2021)
Volume 10
Issue 1
Antibodies, Vol 10, Iss 2, p 2 (2021)
The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ac367d39de0fe64e8703feb3c16396
Autor:
Ingrid G. Winkler, Rebecca N. Wellburn, Whitney Fleming, Joshua Tay, Bianca Nowlan, Kavita Bisht, Jean-Pierre Levesque, Valerie Barbier, Crystal McGirr
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8c9eaf485bd66b788f712074e97025
https://doi.org/10.3389/fimmu.2020.583550
https://doi.org/10.3389/fimmu.2020.583550
Autor:
Kavita Bisht, Crystal McGirr, Seo-Youn Lee, Hsu-Wen Tseng, Whitney Fleming, Kylie Alexander, Taichi Matsumoto, Valérie Barbier, Natalie Sims, Gerhard Müller-Newen, Ingrid Winkler, Halvard Bönig, Jean-Pierre Levesque
Publikováno v:
Experimental Hematology. 100:S44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::293741b35dc43d032f5207941168e588
https://doi.org/10.1016/j.exphem.2021.12.225
https://doi.org/10.1016/j.exphem.2021.12.225
Autor:
Ingrid G. Winkler, Warren S. Alexander, Jean-Pierre Levesque, Valerie Barbier, Andrew C. Perkins, Keerthana Krishnan, Jianmin Ding, Crystal McGirr, Ann E.O. Trezise, Peter Papathanasiou, Paula L. Hawthorne, Thomas J. Gonda, Pamela Mukhopadhyay, Diwakar R. Pattabiraman, Konstantin Shakhbazov, Sean M. Grimmond
Publikováno v:
Blood. 123:2682-2690
The MYB oncogene is widely expressed in acute leukemias and is important for the continued proliferation of leukemia cells, suggesting that MYB may be a therapeutic target in these diseases. However, realization of this potential requires a significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549141d1b042dbbb642b89f1388b95b9
https://doi.org/10.1182/blood-2012-02-413187
https://doi.org/10.1182/blood-2012-02-413187
Publikováno v:
Cancer Letters. 343:98-106
The effect of combining MYB suppression with the histone deacetylase inhibitor LBH589 was studied inhuman myeloid leukemia cell lines. MYB knockdown inhibited proliferation and induced apoptosis inU937 and K562 cells in vitro, and also sensitized bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211ddcd90ad6fccb950140369f7a9f84
https://doi.org/10.1016/j.canlet.2013.09.022
https://doi.org/10.1016/j.canlet.2013.09.022
Autor:
Kylie A. Alexander, Kavita Bisht, Ingrid G. Winkler, Whitney Fleming, Gerhard Müller Newen, Crystal McGirr, Jean-Pierre Levesque, Natalie A. Sims
Publikováno v:
Blood. 134:4469-4469
Granulocyte colony-stimulating factor (G-CSF) and the CXCR4 chemokine receptor antagonist Plerixafor are used to mobilize hematopoietic stem and progenitor cells (HSPC). However, in the autologous setting, prior chemotherapy and radiotherapy impair H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::684881467ca5e0a3c938c3463d894b82
https://doi.org/10.1182/blood-2019-127431
https://doi.org/10.1182/blood-2019-127431